Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

Please feel free to read, share your thoughts, your stories and connect with others!
User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

Postby DK37 » Fri Sep 23, 2016 7:24 am

THIS IS BIG potential news for the CRC, Lung and Pancreatic cancer worlds. Just announced: the initiation of a KRAS-mutant directed personalized cellular therapy Phase 1 clinical trial for SOME segments of the KRAS-mutant CRC, Lung and pancreatic cancer patient populations - it will depend on the exact mutation and your HLA type. They have not announced the exact mutations or required HLA types yet - but will soon. I will post as soon as available.

The "drugs" will be living immune cells.

It is essentially an effort to commercialize in a more logistically efficient way the NIH TIL trial but limited to only certain slices of patients with certain KRAS-mutations and HLA-types

Expect a lot more info to be coming out soon. From a technology point of view, this is BIG. I'll be writing a science blog about it soon.

I'll announce (and explain) more details as they come out - this is just an exciting teaser press release, but they say trial will start in 2016.

http://www.businesswire.com/news/home/2 ... 006760/en/

Welcome to the future!
-DK37
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

aja1121
Posts: 201
Joined: Sat Jun 28, 2014 5:12 pm

Re: Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

Postby aja1121 » Fri Sep 23, 2016 9:10 am

Thank you for all the work you do to keep us informed. The hope you provide is immeasurable, but we always need to remember you do this work while fighting your own battle. I, for one, am eternally grateful.
DH dx Stage 3B rectal ca 5/23/14 (age 41) from Mpls, MN
6/14 Xeloda + 30 rad
10/14 LAR/ileo, all 12 nodes clean
12/14-04/15 FOLFOX x 10
05/15 VATS, single lung met
06/15 ileo reversal, 09/15 local recurrence, 10/15 permanent colostomy
11/15 FOLFIRI x 4, 01/16 major growth, 10 more rad
02/16 curative resection failed, tumor debulked
03/16 FOLFOX x 4
11/16 Xeloda/Avastin until progression seen 08/17
09/17 start NCT02024607 (BBI608 + FOLFIRI arm)

dmondgirl
Posts: 104
Joined: Thu Apr 14, 2016 1:54 pm

Re: Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

Postby dmondgirl » Fri Sep 23, 2016 9:41 am

Thank you for taking the time and keep us inform!!! Praying that one day soon very soon this will just be like any other health condition.
Fiance – Diagnosed 7/ 2015 @ 41yrs old- rectal cancer
Initial staging - T3N0M0
4 tx of Folfox/5FU
28 radiation with Xeloda
LAR surgery 3/17/16 final stating T2N1M0.

Rough Recovery
9/16-Recurrence @ resected area
Biopsy - Poorly differentiated adenocarcinoma, with signet ring cell features & neuroendocrine differentiation.

8 tx of Folfiri! No shrinkage everything stable .. lymph nodes behind his abdominal area grew a little bit
4 tx of Erbitux + Irinotecan- No shrinkage everything stable

User avatar
BrownBagger
Posts: 7954
Joined: Fri Jul 24, 2009 2:56 pm
Location: Central NYS

Re: Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

Postby BrownBagger » Fri Sep 23, 2016 10:21 am

Yes, thanks!

This is the kind of thing I live for.
Eric, 58
Dx: 3/09, Stage 4 RC
Recurrences: (ongoing, lung, bronchial cavity, ribs)
Major Ops: 6/ RFA: 3 /bronchoscopies: 8
Pelvic radiation: 5 wks. Bronchial radiation—brachytheray: 3 treatments
Chemo Rounds (career):136
Current Chemo Cocktail: Xeloda & Erbitux & Irinotecan biweekly
Current Cocktail; On the Wagon (mostly)
Bicycle miles post-dx 10,477
Motto: Live your life like it's going to be a long one, because it just might, and then you'll be glad you did.

KElizabeth
Posts: 386
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

Postby KElizabeth » Thu Sep 29, 2016 4:48 am

Thanks for posting this. I'll be watching for more details on this.
Female age 38- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 -current
CEA at recurrence:10.1/august, 2015
CEA: 1.9 February, 2016
CEA: 16.4 March 2017
CEA: 90.1 October 2017

User avatar
CRguy
Posts: 9287
Joined: Sun Feb 10, 2008 6:00 pm

Re: Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

Postby CRguy » Thu Sep 29, 2016 7:47 pm

This IS huge my friend !!!

A lot has been discussed in the past about "immune therapies" generally
BUTT not all of the horses in the stable were really ready to run the race

THIS kind of concept IS ready to get into the race
Stay tuned to the future indeed.

Cheers and best wishes
CRguy
Caregiver x 3
Stage IV A rectal cancer/lung met
10 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

flyboy22
Posts: 21
Joined: Sun Jan 31, 2016 12:01 pm

Re: Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

Postby flyboy22 » Tue Mar 28, 2017 1:01 am

Any updates on this trial? Did they ever begin it? Are they still recruiting?
DH to wife 38, DX 12/14, Rt. clctmy Xmas
St. IIIB, pT3N2aM0, 4/27 nodes, mod. dif
KRAS (G12V), APC, TP53, MSS, vasc/lymph/perineural +
TX FOLFOX 1/15-6/15 (4 no oxi)
7/16 mets to retropertnl, iliac, supclavic. nodes
TX 9/16 FOLFIRI+Avast
1/17: Numerous bilateral lung mets; nodes stable/growth; FOLFIRI fail
TX 1/17 FOLFOX+Avast.
3/17: lung mets grow/new, nodes stable/growth, FOLFOX fail
no clinical trials
TX 9/17 Lonsurf
11/17 growth in lungs, nodes; mets to ovary, abdomen, and likely liver
11/17 hospice

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

Postby DK37 » Sat Apr 01, 2017 6:41 am

flyboy22 wrote:Any updates on this trial? Did they ever begin it? Are they still recruiting?


The latest (rumor, unofficial) update I heard was about a month ago - saying that the trial was still planned for 2017 but would not start until a bit later in the year.

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: Baidu [Spider], Bing [Bot], Google [Bot], Yahoo [Bot] and 34 guests