Help--looking for feedback from folks with XELIRI experience *and* analytical/clinicall/ statistical information as to strengths or drawbacks to shifting from fluorouracil (via pump) with infused irinotecan and infused AVASTIN, to oral capecitabine (XELODA) plus infused irinotecan and Avastin.
Background/Context: Last week, I finished my seventh round of FOLFIRI with AVASTIN--had reluctantly gone to a port on condition that I could use a small, non-mechanical, non-electronic "tennis ball" pump for irinotican. following minor growth of lung mets after two years stability and shrinking with "vaccine" (Chang/Nesslehut Dendriti thing) for a year and then Xeloda and Avastin for a year plus. The Fofiri appears to be working; however the hospital just put the kibosh on the small pump, and I need to work and work out and try to remain somewhat discreet about my condition--I have not told employer or clients, or most people and intend to keep it that way until this disease progresses to a prohibitive point.
Oncologist has suggested that capecitabine (XELODA) combined with Irinotican and Avastin is a good solution--I would only be in for an infusion once every three weeks, no pump and I have a record of tolerating XELODA. I am attaching an article that indicates the clinical effects are very similar and side effects not too much worse, but I am hoping for feedback from Colon Talk folks who either have experienced the two, or who are knowledgeable and more scientifically savvy and I vis-a-vis the research on this.
URGENCY: This requires a scheduling change in a busy infusion clinic, next week. Already a big monkey wrench in the system, and I need to advise them and lobby in a hurry.
https://www.ncbi.nlm.nih.gov/pmc/articl ... po=44.7368Thanks,
Peter
DX Aug. 2013 Resection 09/13.
08/14 CT : .7 CM pulmonary nodule--& multiple nodules.
03/15 15 dendritic cell vaccine-monthly
05/16 begin 3000 MG Xeloda & Avastin
11-16 shrinkage.”Sstable"
2/2017: Port installed. Begin Folfiri and Avastin
8/2017: Xeloda, Avastin and Iranotican. 3-wk cycle.
2-6-18: small pulmonary embolim—some growth in one pulmonary tumor. Start Xarelto.
2-8-18 : Change of chemo: Xeloda with Oxaliplatin no avastin.
9/2018: Tumor growth. Begin Stivarga.