New MSS-CRC Immunotherapy Trial: Arginase Inhibitor CB-1158

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

New MSS-CRC Immunotherapy Trial: Arginase Inhibitor CB-1158

Postby DK37 » Sun Sep 18, 2016 6:26 pm

A new MSS-CRC immunotherapy trial - NCT02903914.

A novel mechanism, an "arginase inhibitor" named "CB-1158". Arginase is immunosupressive and it has been known for years to be a clinical marker for CRC - so they are specifically recruiting MSS-CRC patients for an arm of the trial. I am glad for the steady increasing focus on MSS-CRC in immunotherapy clinical trials! My guess is that they will eventually test it in combination with PD1 in MSS-CRC patients but they are only testing CB-1158 alone to start (in CRC)...

https://clinicaltrials.gov/ct2/show/NCT ... 914&rank=1

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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Steph20021
Posts: 492
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: New MSS-CRC Immunotherapy Trial: Arginase Inhibitor CB-1158

Postby Steph20021 » Fri Sep 23, 2016 5:32 am

I love that there are more irons in the fire for MSS. Thanks for sharing DK. It's news I love to read!
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Currently stable suce Aug/16- on folfiri

testing765
Posts: 308
Joined: Tue Aug 19, 2014 9:41 am

Re: New MSS-CRC Immunotherapy Trial: Arginase Inhibitor CB-1158

Postby testing765 » Sat Sep 24, 2016 6:12 pm

Thank you for the information DK37. This does sound encouraging. CB-1158 may become one part of a combination immunotherapy strategy for MSS-CRC.
male-age 44 at diagnosis
8/14-clnscopy
8/14-CT scan,no mets
9/14-left colectomy,CEA 2.2 before surgery
pT2pN2bpM0
3 cm tumor in dscnding colon
7/23 pos LNs
low grade MSI stable
10/14-start folfox
1/15-CT & PET scan and sigmdoscopy- no mets
3/15-finish folfox
9/15- clnscopy- 3 polyps removed
10/15- CT scan, NED
10/16- CT scan, NED, CEA 1.6
10/17- clnscopy- 4 polyps removed, CT scan NED, CEA 1.8
10/14 1.9; 4/15 2.8; 5/15 2.4; 9/15 2.8; 12/15 3.1; 1/16 3.0; 4/16 2.5; 7/16 2.5; 10/16 1.6; 1/17 1.9


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