Immunotherapy Trial: Patients WITH Brain Metastases

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Immunotherapy Trial: Patients WITH Brain Metastases

Postby DK37 » Fri Sep 02, 2016 11:37 am

FOR PATIENTS WITH BRAINS METASTASES

Many trials exclude patients with brain metastases. This new trial opening up (Boston, NCT02886585) is specifically recruiting patients WITH brain metastases. The experimental treatment will be a mixture of SBRT + PD1. It is open to both MSS and MSI-high CRC patients.

https://clinicaltrials.gov/ct2/show/NCT ... 585&rank=1

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

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CRguy
Posts: 9287
Joined: Sun Feb 10, 2008 6:00 pm

Re: Immunotherapy Trial: Patients WITH Brain Metastases

Postby CRguy » Fri Sep 02, 2016 1:54 pm

Thanks once again for this important news, bro' !

I know there are folks here and on FB which this may impact and your updates here are ALWAYS the first thing I look for
... and further thanks for keeping your ongoing sticky current = a great resource !

Cheers and Harmony coming atcha'
CR on the Journey
Caregiver x 3
Stage IV A rectal cancer/lung met
10 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

nomoretacos
Posts: 48
Joined: Sun Mar 27, 2016 5:57 pm

Re: Immunotherapy Trial: Patients WITH Brain Metastases

Postby nomoretacos » Sat Sep 03, 2016 12:43 am

Is it okay if I ask a question regarding brain metastases? if it doesnt really belong here I can post a new thread

People who have CT scans after first being diagnosed and those who are NED receiving follow up scans, do they usually include scans of the brain, or just chest/abdomen? I raised the question of brain metastases with my onc during our first meeting and she brushed it off really quickly saying brain metastases are really rare
03/16 Dx Stage IIIC, sigmoid resection surgery,T3 N2b M0, 7/20 nodes, 4 tumor deposits, CEA 3.7, age 31
04-10/16 Folfox with delays and reductions
10/16 Post chemo CT scan shows two non specific spots (one liver, one lung)
11/16 Port removed
12/16 CEA 0.9
09/17 NED

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: Immunotherapy Trial: Patients WITH Brain Metastases

Postby DK37 » Sun Sep 04, 2016 7:48 am

nomoretacos wrote:Is it okay if I ask a question regarding brain metastases? if it doesnt really belong here I can post a new thread

People who have CT scans after first being diagnosed and those who are NED receiving follow up scans, do they usually include scans of the brain, or just chest/abdomen? I raised the question of brain metastases with my onc during our first meeting and she brushed it off really quickly saying brain metastases are really rare


A good question. Brain mets are relatively rare in CRC (off the top of my head I think occur in 3-5% of Stage IV CRC cases, so much lower likelihood than other anatomical sites but certainly not incredibly rare, I have had a number of friends with them). It is standard of care to not include brain scans as a part of normal monitoring.

For those with active Stage IV disease, I have heard second-hand that MDA is including a brain scan check of patients with active lung mets (at 2 year mark?) but I do not know that info first-hand. In my anecdotal observations, it has appeared they are often discovered via a brain scan ordered due to 1.) A significant rise in CEA without any obvious cause seen in the standard chest-pelvis CT-scans 2.) Neurological clinical symptoms

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

Sams wife
Posts: 749
Joined: Sun Jan 11, 2015 2:49 pm

Re: Immunotherapy Trial: Patients WITH Brain Metastases

Postby Sams wife » Sun Sep 04, 2016 9:04 am

Nomoretacos. My husband had a spot on his nose that went away during chemo. It has since came back. I'm not sure if it was just that or him falling & hitting head a few times, but they started scanning his head. I think they still are. Will see this month !
Husband dx 1/13/15 St.2 CEA 7.1
Chemo/25rad 2/15 till 4/24/15
5FU/leucovorin
Surgery 6/8/2015 Stage IIa T3N0MX microscopic cancer left
Watching 4 lung spots
0/5 lymph nodes. Lap. APR
25% less 5FU/leucovorin 7/14/2015 x 26 CEA 3.4
25% more 5fu 9/2015
9/16/15 CEA 7.7
1/16/16 @ 9.2 during allergy?
3/16 New lung spot 4x4 mm
6/16 CEA 6.9 spot 5x5

nomoretacos
Posts: 48
Joined: Sun Mar 27, 2016 5:57 pm

Re: Immunotherapy Trial: Patients WITH Brain Metastases

Postby nomoretacos » Mon Sep 05, 2016 6:54 am

Thanks guys for answering my question, makes me feel a bit more at ease knowing it is standard practice not to scan the brain unless there is a reason
03/16 Dx Stage IIIC, sigmoid resection surgery,T3 N2b M0, 7/20 nodes, 4 tumor deposits, CEA 3.7, age 31
04-10/16 Folfox with delays and reductions
10/16 Post chemo CT scan shows two non specific spots (one liver, one lung)
11/16 Port removed
12/16 CEA 0.9
09/17 NED


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