MEDI4736 CLINICAL TRIAL (KEYTRUDA)

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: MEDI4736 CLINICAL TRIAL

Postby Maia » Mon Jan 30, 2017 7:44 pm

Great news, keep going! : )

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Wed Feb 22, 2017 3:48 pm

Update:
So my numbers are getting better: CEA 120.8. BILIRUBIN. .4 Body weight 157.5 lbs. I'm also feeling a lot better and eating at least 3 times a day, plus snacks. C'mon Keytruda! The only real side effect so far is fatigue, but imma up my iron intake, which should bring up my RBC, which is always low.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

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Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: MEDI4736 CLINICAL TRIAL

Postby Maia » Wed Feb 22, 2017 4:32 pm

Rob, I'm im awe looking at your CEA trend, the going down, since you started the immunotheray!!
How do you care about the bile duct? Re-stenting...?
Keep well!!!

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Wed Feb 22, 2017 9:58 pm

Maia...I have 2 bile drains. The internal medicine doc still wants to keep them draining, just in case, although I have capped them at times in order to assess if the restrictions on my bile ducts are decreasing. For Monday's test I had them capped for 3 days and bilirubin was 0.4.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Tue Mar 14, 2017 5:47 pm

Update: Keytruda Round 5.
CEA...98. Bodyweight...162.7 Bilirubin... .6
A couple of bad days last week, probably because I was too out there and exposed to many germs...gotta take it easy. Thanks everyone for the prayers...seems to be working.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

stu
Posts: 603
Joined: Sat Aug 17, 2013 5:46 pm

Re: MEDI4736 CLINICAL TRIAL

Postby stu » Tue Mar 14, 2017 6:08 pm

Hi,
Great watching that CEA drop... big time!!
Delighted your doing well on it. Maybe build in a wee bit rest too :D
Take care,
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared

aja1121
Posts: 201
Joined: Sat Jun 28, 2014 5:12 pm

Re: MEDI4736 CLINICAL TRIAL

Postby aja1121 » Tue Mar 14, 2017 8:54 pm

Great news!
DH dx Stage 3B rectal ca 5/23/14 (age 41) from Mpls, MN
6/14 Xeloda + 30 rad
10/14 LAR/ileo, all 12 nodes clean
12/14-04/15 FOLFOX x 10
05/15 VATS, single lung met
06/15 ileo reversal, 09/15 local recurrence, 10/15 permanent colostomy
11/15 FOLFIRI x 4, 01/16 major growth, 10 more rad
02/16 curative resection failed, tumor debulked
03/16 FOLFOX x 4
11/16 Xeloda/Avastin until progression seen 08/17
09/17 start NCT02024607 (BBI608 + FOLFIRI arm)

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Fri Apr 21, 2017 9:24 pm

Update: Keytruda Round 6
CEA 83.6 BODYWEIGHT 173 BILIRUBIN .7
Feeling better. Got a couple of workouts in...strong as a kitten. Very far from my powerlifting days, but looking forward to getting back on the jitsu mats once these bilitubes get taken out. GO KEYTRUDA!!!
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

jortego128
Posts: 272
Joined: Sat Aug 15, 2015 7:47 am

Re: MEDI4736 CLINICAL TRIAL

Postby jortego128 » Sun Apr 23, 2017 8:45 am

Hey Big Rob, fellow jiu-jitsuka here, awesome that you feel good enough to step back on the mat!

Image

Image

Image
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Mon Apr 24, 2017 1:49 pm

It's one of the things that keeps me going. Haven't trained in 2 years, but I got jits in the brain and watch vids every day. When these tubes come out imma start drilling and maybe teach a morning class. Good luck in your jits journey.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: MEDI4736 CLINICAL TRIAL

Postby Maia » Sat Apr 29, 2017 2:11 pm

Jortego, what a wonderful pics!! Thanks for sharing them.

Rob, I love seeing the Keytruda continues bringing the numbers down steadily!! Go KEY-truda go!!

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Fri May 12, 2017 11:34 pm

Update: Keytruda round 7.
CEA 64.7 BODYWEIGHT 171 BILIRUBIN .5
Numbers are better, feel healthier, some days still with massive fatigue, but some of those days are due to exposure with other people, particularly at the jits academy, where its sweaty and stuffy from everyone training. It almost feels like a fever, with chills, but I'm able to shake it off after a long nap and morphine. The doctor says the bypass tubes still have to stay in, and my onc will not go against him, so I'm still stuck with these tubes. Shit.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: MEDI4736 CLINICAL TRIAL

Postby Maia » Sat May 13, 2017 9:00 am

SO happy for you, Rob!!

So, are you already back to the jitsu mats? --more a Wushu former girl here, but equally happy to hear about your jitsu. Do not worry about the stents... give it time. :)

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Sat May 13, 2017 2:34 pm

Hey Maia, getting used to all the germs at the academy, so hopefully doing drills by months end. Wushu huh, would like to see some of your moves. Jackie and Jet are wushu guys.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

plastikos
Posts: 273
Joined: Wed Jan 14, 2015 6:09 am

Re: MEDI4736 CLINICAL TRIAL

Postby plastikos » Tue May 16, 2017 10:51 am

Hi Rob. You and I have almost the same course. I also developed jaundice last December and had a biliary stent put in. I still have it. Currently on Keytruda as well and so far so good. Feeling better, gaining weight. Wishing you the best.
Diagnosed St. IV Colon CA @ 37, male, Kras wild type, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab 12/2016 -> pseudoprogression (?), biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab
Sept 2017 - SIRT


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