MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Please feel free to read, share your thoughts, your stories and connect with others!
BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Wed Jun 07, 2017 1:07 am

Update KEYTRUDA round 8.
CEA 32.1 BODYWEIGHT 166 BILIRUBIN 1.2
So I got a throat infection that pushed my treatment back a week. The meds they gave me for it knocked me out...they made me feel depressed, sicker, and I don't think I can finish taking all of them. I'll ask on Friday when I go back. Lost some weight due to the fact it felt like I swallowed glass...much better today. Prior to this infection I was feeling real good so I hope it's a temporary setback.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

User avatar
Maia
Posts: 2443
Joined: Fri Aug 24, 2012 8:00 am

Re: MEDI4736 CLINICAL TRIAL

Postby Maia » Wed Jun 07, 2017 6:15 pm

Woohoo... look at that CEA going down down down.
Nasty throat infection that put you a bit back. Happy to hear it is over! Keep going!! : )

michelle c
Posts: 1845
Joined: Wed Dec 02, 2009 3:58 am

Re: MEDI4736 CLINICAL TRIAL

Postby michelle c » Sat Jun 10, 2017 3:35 am

Great news! Glad it's going well for you! Best wishes
25 May 09 Dx with CC (sigmoid colon) 2 days after my 44th b'day
CEA prior to surgery 4.7
3 Jun 09 LAR - Stage III 3/10 lymph nodes
6 Jul - 10 Dec 09 12 cycles FOLFIRI
Genetic testing - inconclusive for Lynch
Jul 12 port removed & hernia repair

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby BIG ROB 69 » Thu Jul 27, 2017 4:15 pm

Update: Haven't received KEYTRUDA in over six weeks due to this throat infection, but onc says this is the KEYTRUDA working. CEA still down at 32.6, but bodyweight also down to 153 lbs. The good news is that the tumor has shrunk to 7.1×7.0, from 9.6×7.9, and my onc is scambling to aggressively use other methods, including surgery, to get this fucker out. Still fighting.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

NHMike
Posts: 684
Joined: Fri Jul 21, 2017 3:43 am

Re: MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby NHMike » Thu Jul 27, 2017 4:33 pm

BIG ROB 69 wrote:Update: Haven't received KEYTRUDA in over six weeks due to this throat infection, but onc says this is the KEYTRUDA working. CEA still down at 32.6, but bodyweight also down to 153 lbs. The good news is that the tumor has shrunk to 7.1×7.0, from 9.6×7.9, and my onc is scambling to aggressively use other methods, including surgery, to get this fucker out. Still fighting.


I can't imagine those tumor sizes, even the smaller one.

I've asked the surgeon about cutting it out as well and she said that they don't do that - unless it's an emergency maybe?

Thanks for the update.
6/23/17: ER rectal bleeding; Colonoscopy+Biopsy
7/13: Stage 3B rectal cancer. T3, N1b, M0. 5.2 x 4.5 x 4.3 cm. Lymphs: 6 x 4 mm, 8 x 6 mm, 5 x 5 mm
7/31-9/8: Xeloda 3,400 mg/day+radiation
7/5: CEA 2.7; 8/16: 1.9; 9/8: 1.8. 11/30: 0.6
MSS, KRAS G12D
10/6: 2.7 x 2.2 x 1.6 cm (-90%). Lymphs: 3 x 3 mm (-62.5%), 4 x 3 mm (-75%), 5 x 3 mm (-40%). 5.1 CM from AV
10/30: Surgery: LAR, Temp Ileostomy
Path report: Tumor regression grade: 0 (complete response).

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby BIG ROB 69 » Thu Sep 28, 2017 11:04 am

Upsate KEYTRUDA round 8.
Finally got a dose in after months and by the the next day my mouth was sore. For one month prior I was on steroids and felt great, and for a couple of weeks before that they gave me antifungals for the mouth sores and that started my way to feeling good. My guess is the KEYTRUDA plus antibiotics afterwards really fucks me up. I will try to edit in the medication names at a later date. Went to MSK in the city on Monday for a CT SCAN. The board will evaluate my case on Thursday, so by Friday/Monday I should have a better direction on where we're going with this.
TO NEDSVILLE...AND BEYOND!!!
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

User avatar
Jack&KatiesMommy
Posts: 492
Joined: Wed Dec 21, 2011 1:08 pm
Location: Columbus, OH

Re: MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby Jack&KatiesMommy » Thu Sep 28, 2017 12:39 pm

Keep going Rob....youre doing great! A few bumps along the way....hoping htey get the antibiotics and antifungal meds worked out....
Cynthia
Cynthia
Mommy to Jack (8) now (14) and Katie (4) now (10)
(My Most Precious Things)
Dx 8/11 Stage IV CRC (liver mets) CEA 2,600+
9/11 Folfiri 2/12: Failed Liver Resection
5/12 HAI pump/removed primary
4/13 Liver Resection!
8/13; 10/13; 12/13; 3/14; 8/14; 11/14; 2/15; 7/15; 12/15 RFA lungs
5/17: Upper Left Lobe of lung removed in order to resect lymph nodes.
CEA: 1/16 2.5; 3/16 3.3; 5/16 2.8 7/16 3.8 4/17 53 7/17 4.1
NED for now.....

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby BIG ROB 69 » Thu Sep 28, 2017 1:17 pm

Wow, J&K, you've had some journey.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

henry123
Posts: 29
Joined: Sun Oct 08, 2017 3:25 am

Re: MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby henry123 » Wed Oct 11, 2017 4:24 am

BIG ROB 69 wrote:Wow, J&K, you've had some journey.

Hello Big Rob g
Any updates on cea levels.
Henry
46yo M
5/16 lap AR 14/21 L nodes +ve
T4N2M1
cea 80
6/16 Ext Rt hemicolectomy
7/16 Capox 9 cyc
9/16 cea 2
1/17 cea 550
pet shows mets in lung & peri
iri+ avastin failed
3/17 cea 10577
msi-high, lynch+ve
4/17 regro failed
5/17 cea 28800
5/17 CT increase in size of mesentric nodes , new onset of multiple nodules in liver.
6/17 Opdivo start
7/17 cea 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT shows all clear exc a nodule in Lung. liver normal
opdivo to continue
Vegan+ yoga +juicing +apricot seeds

BIG ROB 69
Posts: 62
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby BIG ROB 69 » Wed Oct 11, 2017 10:06 am

Had to stop Keytruda due to mouth sores and throat and mouth infection. Tumor grew and CEA up to 68. They are gonna change my therapy and let's see from there. Gotta gain bodyweight.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

plastikos
Posts: 273
Joined: Wed Jan 14, 2015 6:09 am

Re: MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby plastikos » Wed Oct 11, 2017 1:31 pm

BIG ROB 69 wrote:Had to stop Keytruda due to mouth sores and throat and mouth infection. Tumor grew and CEA up to 68. They are gonna change my therapy and let's see from there. Gotta gain bodyweight.

Sorry to hear this Rob. Hope they find an alternative, maybe another PD-1 inhibitor. Have you ever considered SIRT for the liver tumors?
Diagnosed St. IV Colon CA @ 37, male, Kras wild type, MSI-high (2014)
11/2014 Right Hemicolectomy + Liver Resection
12/2014 - 6/2015 FOLFOX + Cetuximab
10/2015 - Recurrence liver
Liver resection 10/2015
FOLFIRI 11/2015 - 5/2016
Recurrence liver, nodes 11/2016
Pembrolizumab 12/2016 -> pseudoprogression (?), biliary obstruction -> biliary stenting
Chemo 4x: most mets inactive and smaller on PET-CT
March 2017 - Back on Pembrolizumab
Sept 2017 - SIRT

henry123
Posts: 29
Joined: Sun Oct 08, 2017 3:25 am

Re: MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby henry123 » Wed Oct 11, 2017 2:49 pm

BIG ROB 69 wrote:Had to stop Keytruda due to mouth sores and throat and mouth infection. Tumor grew and CEA up to 68. They are gonna change my therapy and let's see from there. Gotta gain bodyweight.

Hope you get well soon.
Shouldn't they be resuming Keytruda once infections are controlled.
I use paste of an Indian product called katha for mouth sores. Really effective. You may get it at some indian grocery store.
46yo M
5/16 lap AR 14/21 L nodes +ve
T4N2M1
cea 80
6/16 Ext Rt hemicolectomy
7/16 Capox 9 cyc
9/16 cea 2
1/17 cea 550
pet shows mets in lung & peri
iri+ avastin failed
3/17 cea 10577
msi-high, lynch+ve
4/17 regro failed
5/17 cea 28800
5/17 CT increase in size of mesentric nodes , new onset of multiple nodules in liver.
6/17 Opdivo start
7/17 cea 26754
8/17 5623
9/17 497
10/17 52
11/17 12
CT shows all clear exc a nodule in Lung. liver normal
opdivo to continue
Vegan+ yoga +juicing +apricot seeds


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: Bing [Bot] and 13 guests