MEDI4736 CLINICAL TRIAL (KEYTRUDA)

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BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Postby BIG ROB 69 » Sun Aug 28, 2016 2:15 am

Hopefully I will start this trial after I clear my jaundice, caused by a little blockage in my bile duct stents. I will be documenting this on a weekly basis for both anyone who needs the info, as well as to keep an active journal for myself. Will post personal stats soon.
Last edited by BIG ROB 69 on Mon Jun 12, 2017 11:44 pm, edited 1 time in total.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

jdepp
Posts: 484
Joined: Sun Sep 28, 2008 7:53 pm

Re: MEDI4736 CLINICAL TRIAL

Postby jdepp » Sun Aug 28, 2016 9:47 am

Thanks Big Rob for posting your results here. It benefits us all. Best wishes to you as you go through it all.
Colon dx 08 @ 41 Poorly diff. 12+ liver mets, 19/28 LN
Colon rsx /14 x Folfox-Erbitux 08-09
PVE / Liver rsx 09
Lung & LN mets 10
Folfiri, Xeloda, Avastin 10-13
Xelox, Erbitux, UFUR, TS-1, Oxi, Lonsurf 14-16
Stivarga & TIL trial 16

User avatar
H is for Hawk
Posts: 103
Joined: Wed May 20, 2015 4:51 pm
Location: eastern Pennsylvania

Re: MEDI4736 CLINICAL TRIAL

Postby H is for Hawk » Sun Aug 28, 2016 11:07 am

MEDI4736 is a novel anti PD-L1 checkpoint inhibitor. Since you are receiving it as a single agent, this implies you are MSI-high. Can you confirm? Most of us here at ColonTalk are MSS.
H is for Hawk (57)
10/14 L. hemi-colectomy 3 x 4 x 1 cm tumor, 13/14 lymph nodes pos. pT4a N2B M0 stage 3 MSS
11/14 - 4/15 12x FOLFOX
5/15 PET scan: 2.5 x 1.5 cm l. colon lesion, peri surface lesion SUV 2.4, adenocar., KRAS wd, BRAF V600E mut
6/15 HIPEC
9/15 Pleural lining & liver mets, CA 19-9: 6000
10/15 Vectibix Tafinlar Mekinist
11/15 1500
1/16 200
2/16 100, add Lentinan
3/16 122
6/16 4500
7/16 20,000, CT scan - three new liver mets
8/16 6700, FOLFIRI
9/16 4900, CT scan - two new liver mets
10/16 2255 vinorelbine

BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Tue Aug 30, 2016 4:01 pm

Had to look up these terms. If you are implying if its hereditary, no one in my family has cancer.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Wed Sep 07, 2016 2:40 am

So since being accepted as a candidate for the trial, I have been in the hospital for 6 days because I was turning jaundice, so a tube was installed in my bile duct and I have an infection in the blood. Went in on 9/1/16 and out on 9/6/16. Antibiotics prescribed for 2 weeks. Lets see if this delays the process. Stay tuned.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

stu
Posts: 588
Joined: Sat Aug 17, 2013 5:46 pm

Re: MEDI4736 CLINICAL TRIAL

Postby stu » Wed Sep 07, 2016 5:29 pm

Hi,
Hope that helps you and lets you get on with the trial. Thanks for keeping us posted.
Kind regards
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared

BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Thu Nov 10, 2016 6:38 pm

So I have been rejected for clinical trial, but will now start immunotherapy drugs. Any thoughts?
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

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Maia
Posts: 2433
Joined: Fri Aug 24, 2012 8:00 am

Re: MEDI4736 CLINICAL TRIAL

Postby Maia » Fri Nov 11, 2016 7:18 am

A friend of mine was in a trial with MEDI4736 (durvalumab) for bladder cancer, but it didn't work for him : (

BIG ROB 69 wrote: but will now start immunotherapy drugs. Any thoughts?


That sounds promising! Which drugs? Off-label/ out of a trial?

BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Sun Dec 04, 2016 11:45 am

Keytruda
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

User avatar
Maia
Posts: 2433
Joined: Fri Aug 24, 2012 8:00 am

Re: MEDI4736 CLINICAL TRIAL

Postby Maia » Sun Dec 04, 2016 11:57 am

Keytruda is an anti PD-1 checkpoint inhibitor. It has been good results from it for some CRC patients who have tumours with MSI-H (microsatellite unstable tumors -high unstability), which accounts for some 15% of the CRC; then, most of the CRC tumours (ca. 85%) are MSS (microsatellite stable) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901118/
. That's why Hawk was asking you about it : )

BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Tue Dec 20, 2016 11:24 am

Ok guys...started Keytruda yesterday...along with blood transfusion. Let's see where this goes.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

Wonderfullymade
Posts: 119
Joined: Tue Jan 12, 2016 4:33 pm

Re: MEDI4736 CLINICAL TRIAL

Postby Wonderfullymade » Tue Dec 20, 2016 12:28 pm

Good luck BR! I have had some pretty good response to Pembro. At least stability.
Wonderfullymade
DX 3/2015 53
Stage IVa CC w/liver met
BRAF/KRAS wild type MSI-High Lynch?
Folfox 3 cycles
5/2015 ER for subtotal colectomomy due to perforated colon, ovary removed
Folfuri/Pantiumumab 5 cycles
8/2015 liver resection, gallbladder removed and new LN
10/2015 CT scan new nodes
10/2015 Pembro started CEA 2.2
5/2017 stable lung things, coltis, lymph nodes stable cea 1/2017 1.1

BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Wed Jan 11, 2017 4:24 am

Second Keytruda infusion yesterday, along with a dose of iron, as I am always low on my red, but whites were ok. I feel pretty good today, and slept all day yesterday after I got home. Was told that I gotta take Xarelto my whole cancer life. I hate taking that shit...it kinda scares me after seeing those commercials against it. Went from 140 lbs to 147 lbs in three weeks.
Last edited by BIG ROB 69 on Thu Jan 26, 2017 10:31 am, edited 1 time in total.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6

User avatar
BeansMama
Posts: 952
Joined: Thu Jan 28, 2016 1:38 am
Location: North Carolina

Re: MEDI4736 CLINICAL TRIAL

Postby BeansMama » Wed Jan 11, 2017 9:54 am

I understand your fear about the Xarelto, I am on Eliquis. It scares me to be on a blood thinner because my counts - particularly my platelets have historically been low. I'm hoping that now I am on immunotherapy with Opdivo things will straighten out and I won't have the bleeding issues I had before.

Keep us posted on how the keytruda works for you!

Keeping you in my prayers,
Beans
41 yrs old
Tumor found 9/2015
Surgery 1 - 11/2015 LAR and colostomy
Surgery 2 - 11/2015 wound vac
Surgery 3 - 12/2015 revise resection, move colostomy
Mets to liver - tumor inoperable - one add'l met destroyed
Stage IVa (T3 N2a M1a)
Primary tumor 9 cm x 7.5 cm x 2 cm
Beginning Folfox 1/2016 - Failed
Beginning Folfiri and vectibix 8/2016 — Failed
Beginning Folfirinox + Avastin 11/2016 - Failed
Beginning Keytruda 1/2017
CEA drop from 345 to 7.3 after starting immunotherapy
Lynch positive 3/2016

BIG ROB 69
Posts: 61
Joined: Sun Aug 28, 2016 2:00 am
Location: Long Island, NY

Re: MEDI4736 CLINICAL TRIAL

Postby BIG ROB 69 » Mon Jan 30, 2017 4:52 pm

3rd shot today...CEA went down to 415...HGB up to 10.0..
still got iron, but that was a good count. Felt not that bad for the most part these past three weeks...almost always sleepy...hopefully it's working. Apollo doesn't wanna do a scan for a while...maybe after next one. Praying a lot.
3/18/2015 DX CC Stage3/4 49YO MALE IN NEW YORK
Inoperable...hepatic artery
11/15 oper to rem block...colon bypass
4/16 oper to remove scar tissue
5/16 Lynch pos.
10/16 Two bile tubes installed to relieve jaundice
So far I have done the three main chemo drug rounds and on 12/19/16 start Keytruda.
No chemo after 8/3/16 CEA: 10/14/16-409 12/19/16- 887 Mostly my CEA was in the 140-180 range.
CEA: 1/9/17-415 1/30/17-156.2 2/20/17-120.8 3/13/17-98 4/21/17-83.6 5/12/17-64.7 6/1/17-32.1
7/25/17-32.6


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