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MEDI4736 CLINICAL TRIAL (KEYTRUDA)

Posted: Sun Aug 28, 2016 2:15 am
by BIG ROB 69
Hopefully I will start this trial after I clear my jaundice, caused by a little blockage in my bile duct stents. I will be documenting this on a weekly basis for both anyone who needs the info, as well as to keep an active journal for myself. Will post personal stats soon.

Re: MEDI4736 CLINICAL TRIAL

Posted: Sun Aug 28, 2016 9:47 am
by jdepp
Thanks Big Rob for posting your results here. It benefits us all. Best wishes to you as you go through it all.

Re: MEDI4736 CLINICAL TRIAL

Posted: Sun Aug 28, 2016 11:07 am
by H is for Hawk
MEDI4736 is a novel anti PD-L1 checkpoint inhibitor. Since you are receiving it as a single agent, this implies you are MSI-high. Can you confirm? Most of us here at ColonTalk are MSS.

Re: MEDI4736 CLINICAL TRIAL

Posted: Tue Aug 30, 2016 4:01 pm
by BIG ROB 69
Had to look up these terms. If you are implying if its hereditary, no one in my family has cancer.

Re: MEDI4736 CLINICAL TRIAL

Posted: Wed Sep 07, 2016 2:40 am
by BIG ROB 69
So since being accepted as a candidate for the trial, I have been in the hospital for 6 days because I was turning jaundice, so a tube was installed in my bile duct and I have an infection in the blood. Went in on 9/1/16 and out on 9/6/16. Antibiotics prescribed for 2 weeks. Lets see if this delays the process. Stay tuned.

Re: MEDI4736 CLINICAL TRIAL

Posted: Wed Sep 07, 2016 5:29 pm
by stu
Hi,
Hope that helps you and lets you get on with the trial. Thanks for keeping us posted.
Kind regards
Stu

Re: MEDI4736 CLINICAL TRIAL

Posted: Thu Nov 10, 2016 6:38 pm
by BIG ROB 69
So I have been rejected for clinical trial, but will now start immunotherapy drugs. Any thoughts?

Re: MEDI4736 CLINICAL TRIAL

Posted: Fri Nov 11, 2016 7:18 am
by Maia
A friend of mine was in a trial with MEDI4736 (durvalumab) for bladder cancer, but it didn't work for him : (

BIG ROB 69 wrote: but will now start immunotherapy drugs. Any thoughts?


That sounds promising! Which drugs? Off-label/ out of a trial?

Re: MEDI4736 CLINICAL TRIAL

Posted: Sun Dec 04, 2016 11:45 am
by BIG ROB 69
Keytruda

Re: MEDI4736 CLINICAL TRIAL

Posted: Sun Dec 04, 2016 11:57 am
by Maia
Keytruda is an anti PD-1 checkpoint inhibitor. It has been good results from it for some CRC patients who have tumours with MSI-H (microsatellite unstable tumors -high unstability), which accounts for some 15% of the CRC; then, most of the CRC tumours (ca. 85%) are MSS (microsatellite stable) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901118/
. That's why Hawk was asking you about it : )

Re: MEDI4736 CLINICAL TRIAL

Posted: Tue Dec 20, 2016 11:24 am
by BIG ROB 69
Ok guys...started Keytruda yesterday...along with blood transfusion. Let's see where this goes.

Re: MEDI4736 CLINICAL TRIAL

Posted: Tue Dec 20, 2016 12:28 pm
by Wonderfullymade
Good luck BR! I have had some pretty good response to Pembro. At least stability.
Wonderfullymade

Re: MEDI4736 CLINICAL TRIAL

Posted: Wed Jan 11, 2017 4:24 am
by BIG ROB 69
Second Keytruda infusion yesterday, along with a dose of iron, as I am always low on my red, but whites were ok. I feel pretty good today, and slept all day yesterday after I got home. Was told that I gotta take Xarelto my whole cancer life. I hate taking that shit...it kinda scares me after seeing those commercials against it. Went from 140 lbs to 147 lbs in three weeks.

Re: MEDI4736 CLINICAL TRIAL

Posted: Wed Jan 11, 2017 9:54 am
by BeansMama
I understand your fear about the Xarelto, I am on Eliquis. It scares me to be on a blood thinner because my counts - particularly my platelets have historically been low. I'm hoping that now I am on immunotherapy with Opdivo things will straighten out and I won't have the bleeding issues I had before.

Keep us posted on how the keytruda works for you!

Keeping you in my prayers,
Beans

Re: MEDI4736 CLINICAL TRIAL

Posted: Mon Jan 30, 2017 4:52 pm
by BIG ROB 69
3rd shot today...CEA went down to 415...HGB up to 10.0..
still got iron, but that was a good count. Felt not that bad for the most part these past three weeks...almost always sleepy...hopefully it's working. Apollo doesn't wanna do a scan for a while...maybe after next one. Praying a lot.