Cleveland Clinic: New CRC Targeted Therapy Trial

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DK37
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Location: San Diego

Cleveland Clinic: New CRC Targeted Therapy Trial

Postby DK37 » Fri Aug 19, 2016 1:20 pm

A new targeted therapy ("CB-839" a "glutaminase inhibitor") clinical trial specifically for CRC patients with PI3KC mutations (e.g. a part of the Foundation report and major cancer center/genomics venders mutation lists). It targets a metabolism enzyme that CRC tumors of that genetic background may be especially sensitive to inhibition, based on preclinical models.

It is combined with Xeloda in the the trial. They saw synergy with 5-FU in preclinical models. You can enter the trial after you have progressed on ANY 5-FU containing treatment plan - so very flexible.

At the Cleveland Clinic
NCT02861300

https://clinicaltrials.gov/ct2/show/NCT ... 300&rank=1

The scientific poster of the Cleveland Clinic's preclinical CRC research:

http://www.calithera.com/wp-content/upl ... g-2015.pdf

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://colorectalmsstrials.org/
2016 Colondar 2.0 Model
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