Combo of radiotherapy + PD1 immunotherapy in MSS-CRC.

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DK37
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Combo of radiotherapy + PD1 immunotherapy in MSS-CRC.

Postby DK37 » Sun Aug 07, 2016 6:52 pm

Combination of radiotherapy (radiation) with PD1 immunotherapy in MSS-CRC.

I just saw a copy of the full ASCO-2016 poster which disclosed the first MSS-CRC clinical data using this combo strategy. Previously I only had seen the abstract...

Summary:
22 MSS-CRC patients evaluated as of ASCO in the preliminary Phase 2 study
Results were judged by CT-scan of tumors that were **not** irradiated, i.e. looking for a systemic immunotherapy effect
1/22 patients (5%) showed tumor shrinkage of >30%
2/22 patients (10%) showed stable disease of >6 months
2/22 patients (10%) showed a "mixed response" i.e. some tumors shrank whereas some tumors grew

Seeing preliminary signs of successful immune activation in 25% of the first 22 patients tested is pretty intriguing... Another sign that additional immunotherapy steps forward will happen... yes, the immune system can see MSS-CRC tumors in some patients when proper combination therapies are found. It is interesting that it uses a common technology (radiotherapy) rather than a brand new drug or technology (other than PD1 of course!).

Three current related clinical trials open to MSS-CRC patients:
NCT02608385
NCT02837263
NCT02437071

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://colorectalmsstrials.org/
2016 Colondar 2.0 Model
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