MSS-CRC: New Oncolytic Virus + PD1 Inhibitor Trial

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

MSS-CRC: New Oncolytic Virus + PD1 Inhibitor Trial

Postby DK37 » Wed Aug 03, 2016 7:05 am

As mentioned in previous posts - oncolytic virus therapy has shown potentially some but not clearly high efficacy against CRC in the past but many scientists believe/hope that this treatment modality may be "rescued" by co-dosing with a PD-1 inhibitor.

A new trial has opened up in Indiana to test this hypothesis - they are specifically interested in testing against CRC.
NCT02636036
https://clinicaltrials.gov/ct2/show/NCT ... 036&rank=1

Cheers,
-DK37
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

Steph20021
Posts: 492
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: MSS-CRC: New Oncolytic Virus + PD1 Inhibitor Trial

Postby Steph20021 » Wed Aug 03, 2016 9:10 am

Thanks DK for sharing. I hope someone mss has luck with something soon, and they hit it outta the park.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Currently stable suce Aug/16- on folfiri

teri3
Posts: 346
Joined: Fri Jan 09, 2015 11:03 am

Re: MSS-CRC: New Oncolytic Virus + PD1 Inhibitor Trial

Postby teri3 » Wed Aug 03, 2016 10:12 am

Thanks DK I've been getting a little discouraged :( This offers hope
58 yrs old female
MSS KRAS mutation G12V
adenocarcinoma sigmoid colon dx 11-14
sigmoidectomy 11-14
Stage 3A
3 out of 20 lymph nodes involved
started FolFox 1-27-15
11 rounds FOLFOX last one 6-30-2015
7-29-2015 PET clear
5-14-2016 CT 2 nodules one in each lung
Confirmed pulmonary metastasis stage 4
FOLFIRi + Avistin started 8-16 11 rounds complete 12-16
CT 12-16 nodules shrunk chemo break wait and see :?

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juliej
Posts: 2739
Joined: Thu Aug 05, 2010 12:59 pm

Re: MSS-CRC: New Oncolytic Virus + PD1 Inhibitor Trial

Postby juliej » Wed Aug 03, 2016 5:26 pm

Interesting combination, DK. The virus might work to overcome checkpoint resistance. Plus, this particular virus (enadenotucirev) has been shown to directly stimulate immune cell activity and act synergistically with checkpoint inhibitors. Keeping fingers crossed for good results from this one!

Juliej
Stage IV, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/11
LAR, liver resec, HAI pump 11/11
Double lung surgery + ileo reversal 2/12
Adjuvant Xeloda 3-9/12
VATS rt. lung 12/21/12 - benign granuloma!
NED 3/17/12 to 10/2/2017, CEA<1


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