Could radioactive iodine for thyroid cancer cause colon cancer?

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Skoliv
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Joined: Thu Nov 27, 2014 3:50 am

Could radioactive iodine for thyroid cancer cause colon cancer?

Postby Skoliv » Thu Jul 21, 2016 8:05 pm

I had to take some radioactive iodine for my thyroid cancer in 2008 and was wondering if this could have caused or at least helped create my huge cancerous polyp removed in 2014. Has anyone else ever taken this or heard of a relation between the two?

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CRguy
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Joined: Sun Feb 10, 2008 6:00 pm

Re: Could radioactive iodine for thyroid cancer cause colon cancer?

Postby CRguy » Thu Jul 21, 2016 9:25 pm

Have never heard of a link personally. The Iodine (131 I believe ?) is usually concentrated into the thyroid as that is the preferred site of uptake for Iodine. The enduring "radioactivity" is usually of short duration. We use it for hyperthyroidism in felines and when the cats get treated they are housed in a "clean recovery" facility for only 5-6 days ... so I would not expect a CRC link in humans after similar treatment.

BUTT ... you know there has to be at least ONE !!!! ... most cats treated with hyperthyroidism are already very senior to geriatric and if any enduring effects were to arise they may not have been around long enough after treatment to show any new problems.

Interesting question, don't rule anything out and maybe check with your Oncs to see what they can add to the discussion.

Cheers
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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GrouseMan
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Location: SE Michigan USA

Re: Could radioactive iodine for thyroid cancer cause colon cancer?

Postby GrouseMan » Fri Jul 22, 2016 12:53 am

My former supervisor had the same treatment for thyroid cancer. That was I believe over 15 years ago, and he has not developed any secondary cancers as a result so far. Seeing as he also worked in Oncology drug discovery I believe he is VERY vigilant.

Its known that treatment for one cancer does often result years later in other cancers. But I believe that is becoming much rarer now that the treatments are becoming less destructive to ones healthy cells. Less radiation use now, more focused and CT scans with much lower dosages of x-rays compared to the old standard X-Rays one use to get 25 or more years ago. Movement away from really toxic DNA interculators.

The radioactive Iodine is very active but short lived in its radioactivity. In a matter of about a week to 10 days or so you can't detect it usually as it falls below background. But this is what makes it the best treatment for Thyroid cancer. It is taken up pretty selectively by the tumor and accumulates there even in its mets. Because of the intensity of the radioactivity it kills these tumor cells, but since its not taken up by normal non cancerous thyroid cells - it becomes pretty harmless to them quickly because of the radioactive decay to non radioactive elements and the much lower exposure due to it not being taken up by the normal tissues.

Its more likely a stray cosmic ray got your colon when you where high up in the atmosphere when you took a flight somewhere. Everyone try's to look for answers, but with cancer its a needle in a hay stack. way to many factors play into it. Most genetic, some environmental.

Good Luck

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

Lydia666
Posts: 676
Joined: Sat Jun 06, 2015 6:50 pm
Location: Montreal, Canada

Re: Could radioactive iodine for thyroid cancer cause colon cancer?

Postby Lydia666 » Fri Jul 22, 2016 10:32 am

I had thyroid and colorectal cancer because of a gene mutation. I did not have iodine treatment for the thyroid, surgery only.
Oct 2012- thyroid cancer
June 19, 2015 Dx@39 yrs- CRC-T3N1M0
No vascular, no perineural invasion
Aug-Sept 2015- 28 rad/5FU
Oct 28, 2015- LAR- temp ileo, neg. nodes- 0/11
March 2016- 6 rounds Xeloda/positive CHEK2 mutation
August 2016- DCIS and decided post prophylactic double mastectomy
May 2018 - clean CT
Sept 2018-clean scope
Devastation, total shock- oct 2018, invasion of peri mets
Dec 20 - 2 round of folfox
Mom to 4 & 7 yrs kids - at least i brought them to this level of independence.

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steiconi
Posts: 115
Joined: Thu Jun 26, 2008 10:16 pm

Re: Could radioactive iodine for thyroid cancer cause colon cancer?

Postby steiconi » Fri Jul 22, 2016 11:30 am

I had colon cancer, and 4 years later was diagnosed with thyroid cancer and had the radioactive treatment.
The colon cancer has not recurred in the 3 years since the treatment.
I am not my disease.

Skoliv
Posts: 49
Joined: Thu Nov 27, 2014 3:50 am

Re: Could radioactive iodine for thyroid cancer cause colon cancer?

Postby Skoliv » Sun Jul 24, 2016 10:19 pm

GrouseMan wrote:My former supervisor had the same treatment for thyroid cancer. That was I believe over 15 years ago, and he has not developed any secondary cancers as a result so far. Seeing as he also worked in Oncology drug discovery I believe he is VERY vigilant.

Its known that treatment for one cancer does often result years later in other cancers. But I believe that is becoming much rarer now that the treatments are becoming less destructive to ones healthy cells. Less radiation use now, more focused and CT scans with much lower dosages of x-rays compared to the old standard X-Rays one use to get 25 or more years ago. Movement away from really toxic DNA interculators.

The radioactive Iodine is very active but short lived in its radioactivity. In a matter of about a week to 10 days or so you can't detect it usually as it falls below background. But this is what makes it the best treatment for Thyroid cancer. It is taken up pretty selectively by the tumor and accumulates there even in its mets. Because of the intensity of the radioactivity it kills these tumor cells, but since its not taken up by normal non cancerous thyroid cells - it becomes pretty harmless to them quickly because of the radioactive decay to non radioactive elements and the much lower exposure due to it not being taken up by the normal tissues.

Its more likely a stray cosmic ray got your colon when you where high up in the atmosphere when you took a flight somewhere. Everyone try's to look for answers, but with cancer its a needle in a hay stack. way to many factors play into it. Most genetic, some environmental.

Good Luck

GrouseMan



Wow, very informative. Thanks!! True, I am just looking for answers... Maybe I just need the accept that I will never understand why.

Thank you all for your reply!


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