Immunotherapy Combo Treatment for broader range of CRC subtypes

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joe7777777
Posts: 33
Joined: Sat Feb 28, 2015 12:48 pm

Immunotherapy Combo Treatment for broader range of CRC subtypes

Postby joe7777777 » Fri Jul 08, 2016 3:47 pm

Immunotherapy Combo Treatment that treats a broader range of CRC subtypes.

The possibilities on combinations is what makes Immunotherapy treatments so promising and only one has to work.

HIV was turned into a chronic disease using combination treatments. They said this would never happens because the virus mutates, evolves

well thats what cancer does it evolves however the immune system can evolve to defeat cancer.

There are over 20 checkpoint inhibitors being researched as well scientists are working on using genetically altered T -Cell and Killer immune cells.

Then there is the possibility of combining targeted therapy or oncolytic virus s with immunotherapy


http://immuno-oncologynews.com/2016/07/ ... mbination/

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ktwmn
Posts: 350
Joined: Tue Aug 02, 2011 9:41 am

Re: Immunotherapy Combo Treatment for broader range of CRC subtypes

Postby ktwmn » Fri Jul 08, 2016 4:55 pm

Please see Tom's DK 37 Science Posts List. This is the trial that he references in several of his recent posts regarding the combination of cobi (MEK inhibitor) and atezo reported in this year's ASCO meetings showing some promise for MSS patients.
Dx 7/11, Stage IIIc CC
12 txs Folfox 8/2011-2/2012
MSS, KRAS-mut G12D
NED until 3/2015, mets to liver and peritoneum
April-December 2015: 15 txs folfiri+avastin
Liver mets resolved; pelvic met remains
January-May 2016: folfox+avastin; allergic rxn to oxi
June-August 2016: 5FU+avastin
October 2016: looking into immuno trial
January 2017: maintenance chemo xeloda + avastin

NateA
Posts: 115
Joined: Sun Aug 02, 2015 7:41 pm
Facebook Username: Nathan Drew Allen

Re: Immunotherapy Combo Treatment for broader range of CRC subtypes

Postby NateA » Sat Jul 09, 2016 8:05 pm

This trial also skipped phase2 and went right to phase3. There is HOPE!
7/15 dx CC stage 4 with lots of liver mets CEA 208
KRAS Mutant G12V, MSS.
9/23 from folfoxiri to folfox and Xeloda. CEA 25
11/11/15 all liver markers in the zone, CEA 4.0, moving to Avastin/xeloda for now..tumors shrinking
01/13/16 Avastin/xeloda CEA 3.5
03/11/16 clean PET CEA 4.4


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