Phase 2 Clinical Trial: BAX69 + either 5-FU or Panitumumab SoC

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DK37
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Phase 2 Clinical Trial: BAX69 + either 5-FU or Panitumumab SoC

Postby DK37 » Wed Jun 15, 2016 6:48 am

Here a trial that may be of interest to anyone looking for a relatively "easy' trial that may in theory increase response rates/duration etc through synergy. It is in Phase 2, so everyone gets the experimental drug and it is added on to the standard of care medications you would be getting anyways. It is open to both KRAS-wildtype and KRAS-Mutant; >10 sites nationwide

It is a drug called "BAX69"; its mechanism is inhibiting "Macrophage Migratory Inhibition Factor (MIF)" Here are a series of links if you are interested in discussing this kind of trial with your MD.

Trial Link: https://clinicaltrials.gov/ct2/show/NCT ... 810&rank=1

Phase 1 side effect & proof of mechanism: http://meetinglibrary.asco.org/content/152141-156

Preclinical paper: http://www.ncbi.nlm.nih.gov/pmc/article ... l-15-1.pdf

Cheers,
DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
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