New MSS-Elegible PDL1 Combo Trial (RO6895882, CEA-targetted IL2)

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DK37
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New MSS-Elegible PDL1 Combo Trial (RO6895882, CEA-targetted IL2)

Postby DK37 » Tue May 31, 2016 3:51 pm

I think I have posted this MSS-eligible immunotherapy trial before but I noticed today that it has finally opened trial sites in the United States (previously it was Europe only) - so I wanted to repost. Your tumor needs to be CEA-positive. It combines a targeted form of IL-2 "RO6895882" (to activate the immune system in the vicinity of tumor) along with a PDL1 immunotherapy. It has trial locations in NYC and CT. I believe there can be a disconnect between CEA-expression on the tumor itself and what they measure floating in the blood stream - so I would not discard this trial possibility based upon bloodstream CEA results before talking to a MD at the trial. https://clinicaltrials.gov/ct2/show/NCT ... 673&rank=1

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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juliej
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Re: New MSS-Elegible PDL1 Combo Trial (RO6895882, CEA-targetted IL2)

Postby juliej » Thu Jun 02, 2016 5:21 pm

DK37 wrote:I believe there can be a disconnect between CEA-expression on the tumor itself and what they measure floating in the blood stream - so I would not discard this trial possibility based upon bloodstream CEA results before talking to a MD at the trial.

You're right: This study states : "The elevation of serum CEA and the expression of CEA in tissues did not show a direct correlation."
Stage IV, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/11
LAR, liver resec, HAI pump 11/11
Double lung surgery + ileo reversal 2/12
Adjuvant Xeloda 3-9/12
VATS rt. lung 12/21/12 - benign granuloma!
NED 3/17/12 to 10/2/2017, CEA<1

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DK37
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Location: San Diego

Re: New MSS-Elegible PDL1 Combo Trial (RO6895882, CEA-targetted IL2)

Postby DK37 » Thu Jun 02, 2016 6:13 pm

[quote="juliej"
You're right: This study states : "The elevation of serum CEA and the expression of CEA in tissues did not show a direct correlation."[/quote]


Great eyes Juliej!! :) Thanks!

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

Stanfordmom
Posts: 613
Joined: Wed May 14, 2014 1:32 am

Re: New MSS-Elegible PDL1 Combo Trial (RO6895882, CEA-targetted IL2)

Postby Stanfordmom » Thu Jun 02, 2016 9:14 pm

Tom,
do you think this comb will work for KRAS mutant patients?

thanks,
Sha
DX 4/2/2014 at 44, stage 4, mets liver and ovaries
Mom to 2 boys
Three surgeries, HAI pump and lots of chemo
fighting!

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: New MSS-Elegible PDL1 Combo Trial (RO6895882, CEA-targetted IL2)

Postby DK37 » Fri Jun 03, 2016 12:18 am

Stanfordmom wrote:Tom,
do you think this comb will work for KRAS mutant patients?

thanks,
Sha


Hi Sha,

My guess is that KRAS-status won't matter. If this drug strategy works (unknown, being tested right now), my guess is that it would work similarly between KRAS-wildtype and KRAS-mutant.

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List


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