MSS equals Lynch negative?
MSS equals Lynch negative?
If DH is Lynch negative, does that equate to being MSS?
DH T2 N1b M0. 3/15 positive nodes.
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
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Nik Colon
Re: MSS equals Lynch negative?
Most likely, but not definitely. Did you check the MMRs (mismatch repair) on the pathology report? Are all present? That should mean MSS.
Here is a screen shot of mine.
viewtopic.php?f=1&t=53790&p=427416&hilit=Mismatch#p427416
Here is a screen shot of mine.
viewtopic.php?f=1&t=53790&p=427416&hilit=Mismatch#p427416
Re: MSS equals Lynch negative?
Thanks Nik. I didn't get the path report. We are all sort of assuming it won't come back at this point. I just like to be aware. We were only told he is Lynch negative.
DH T2 N1b M0. 3/15 positive nodes.
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
-
Nik Colon
Re: MSS equals Lynch negative?
Here is more info I found.
The results of the MSI test using the NCI panel of 5 microsatellite markers are reported as MSI-High, MSI-Low, and microsatellite stable (MSS). MSI-High level (MSI-H) tumors demonstrate MSI in at least 2 of the 5 markers, MSI-Low (MSI-L) tumors show MSI in only 1 marker, and no instability is detected in any of the 5 markers in MSS tumors.
http://www.medscape.org/viewarticle/571610
The results of the MSI test using the NCI panel of 5 microsatellite markers are reported as MSI-High, MSI-Low, and microsatellite stable (MSS). MSI-High level (MSI-H) tumors demonstrate MSI in at least 2 of the 5 markers, MSI-Low (MSI-L) tumors show MSI in only 1 marker, and no instability is detected in any of the 5 markers in MSS tumors.
http://www.medscape.org/viewarticle/571610
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Nik Colon
Re: MSS equals Lynch negative?
pantufla wrote:Thanks Nik. I didn't get the path report. We are all sort of assuming it won't come back at this point. I just like to be aware. We were only told he is Lynch negative.
Most people are MSS, but you could call and ask the onc to check. Best wishes
Re: MSS equals Lynch negative?
In that case, what are the immunotherapy choices for MSS people?
DH T2 N1b M0. 3/15 positive nodes.
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
-
Nik Colon
Re: MSS equals Lynch negative?
pantufla wrote:In that case, what are the immunotherapy choices for MSS people?
DK recently posted a few, you can check his sticky thread toward the bottom where the new ones are (by date).
viewtopic.php?f=1&t=52822
Re: MSS equals Lynch negative?
Great. 
DH T2 N1b M0. 3/15 positive nodes.
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
Re: MSS equals Lynch negative?
Nik, I just saw the one from May 18, 2016. It's funny how sometimes I don't know what I'm even looking at. Suddenly, I'll read something and have a question and not remember that I already read the answer previously. Thanks for all the information you have.
DH T2 N1b M0. 3/15 positive nodes.
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
Stage IIIA moderately differentiated adenocarcinoma.
Tumor size 6 cm.
Left hemicolectomy 10/26/15.
FOLFOX 11/30/15 to 5/2/16, full 12 cycles.
10/3/16 CT scan clear.
11/10/17 CT: "Focal opacity along the left lower lung, 7 mm. Two small peripheral opacities along the right lower lobe, 2 to 3 mm. A few small to mildly prominent left-sided central mesenteric nodes, up to 13 mm.
June 2019: NED.
2020: NED 5 years. 4 mm lung nodule on CT
-
Nik Colon
Re: MSS equals Lynch negative?
pantufla wrote:Nik, I just saw the one from May 18, 2016. It's funny how sometimes I don't know what I'm even looking at. Suddenly, I'll read something and have a question and not remember that I already read the answer previously. Thanks for all the information you have.
Lol, I know how that is
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