New MSS-CRC Immunotherapy Trial: Erbitux+Keytruda

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New MSS-CRC Immunotherapy Trial: Erbitux+Keytruda

Postby DK37 » Tue May 03, 2016 12:34 pm

Another new MSS-CRC immunotherapy trial-

It combines Erbitux (cetuximab) with Keytruda (pembro) as PD1 inhibitor. It is at the Roswell Park Cancer Institute in Buffalo, New York.

You need to be KRAS and NRAS wild-type and not have taken an EGFR inhibitor previously -- but a previous PD1 inhibitor looks OK. NCT02713373 ... 373&rank=1

6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder:
2016 Colondar 2.0 Model
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Re: New MSS-CRC Immunotherapy Trial: Erbitux+Keytruda

Postby sdino » Fri May 19, 2017 8:18 am

Hi DK37 - hope things are going well for you. Just heard about this trial NCT02713373. We are currently at Roswell Park Inst. with Dr Boland as our Oncologist (clinical trial admin),. As you can see below in my Signature, my wife is KRAS Mut. Would that exclude her from this trial ? Must you be Kras-Wild type ?

We have had some good results (shrinkage lung mets and colon tumor) with standard Chemo. As a matter of fact she is on a 2 month chemo break, so I not going to call our Onc. and take a break from all this stuff until we meet with him in July. thx... sdino
Caregiver for Wife 52 yrs old
DX: 11/16-CC sigmoid colon 3 cm, Lung Bio-Adenocarcinoma Stg IV
Mets: 1.2 cm now 7 mm lung w/14 other nodules less than 6 mm.
3 lymph nodes
MSS, KRAS-mut G12D; TP53;
Chemo: Complete 12 rounds Folfox/Avastin + Oxi 11/16 to 5/17
CT Scans: 11/16; 1/17 lung mets/colon shrinkage; 3/17 lung mets no change, shrinkage lymph/colon tumor, 5/17 colon & lung met shrinkage
CEA: 16 - 11/16; 4 – 12/16; 0.7 – 1/17; 0.5 – 2/17; 0.6 - 5/17

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Re: New MSS-CRC Immunotherapy Trial: Erbitux+Keytruda

Postby Maia » Mon May 22, 2017 2:06 pm

Sdino, yes, being KRAS mutant is exclusion criterion for this trial. But there are many trials for which she qualify!

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Re: New MSS-CRC Immunotherapy Trial: Erbitux+Keytruda

Postby GrouseMan » Mon May 22, 2017 11:10 pm

And the reason they excluded people that have previously used an EGFr inhibitor is because the tumors build up a tolerance to EGFr inhibitors as my wide did. (in combination with Irinotecan and Avastin). However as they have found many times a tumor will again become sensitive to EGFr treatment after a period of time without being treated with an EGFr inhibitor. Apparently the tumors would rather revert back to the EGFr pathway than the alternative ERbb2, 3 and 4 pathways it uses to get around the EGFr pathway blockade. I wish I could find that publication again.

Good luck guys.... Wish I knew about this one and that it were local to us before my wife did the Irrinotecan, Erbitux, Avastin trial.

DW 53 dx Jun 13
CT mets Liver Spleen lung. IVb CEA~110
Jul13 Sig Resct
8/13 FolFox + Avastin 12Tx mild sfx
Ongoing 5-FU Avastin every 3 wks.
CEA: 9/23/13 53 10/21/13 22 12/2/13 8 1/13/14 3.7 8/12/14 2.3 7/2/15 4.0 8/21/15 5.9
7/7/14 CT Can't see the spleen Mets Stable until... CEA up
8/16/15 CT new abdominal spots. Now Iri, 5-FU, Avastin every other week.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen

Achilles Torn
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Re: New MSS-CRC Immunotherapy Trial: Erbitux+Keytruda

Postby Achilles Torn » Wed May 24, 2017 12:37 am

Grouseman. Sorry to hear about your wife's recent blockage. I hope things are getting better.

This is an interesting trial to me as well. You mention ERRB pathways to get around EGFR inhibition. That interests me as I have ERRB4 mutation. Did the paper you read indicate having such a mutation would make EGFR inhibitors ineffective so maybe not the trial for me ?

40 yo Male. DX By Surgeon Dec. 8 2016
Sigmoid Colectomy Dec. 9 2016
Pathology T3N2b?MX 19 of 24 Nodes Positive.
peri colonic tumor deposits 8cm from Tumor. Perineural invasion positive.
PET scan shows Para-Aortic and Iliac Lymph node spread.
Moderately differentiated. MSS. KRAS/BRAF Wild
FOLFOX Commenced Jan 9/2017 - Avastin(Bev) added after 1st round

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