New MSS-CRC Immunotherapy Trial - PDL1/CTLA4/FOLFOX - Liver-only Mets

Please feel free to read, share your thoughts, your stories and connect with others!
User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

New MSS-CRC Immunotherapy Trial - PDL1/CTLA4/FOLFOX - Liver-only Mets

Postby DK37 » Mon May 02, 2016 11:38 am

There are 2 new MSS-CRC immunotherapy trials announced today (neither is recruiting yet - but announced. I'l post as 2 separate posts. Here is #1.

#1 - This one makes a lot of scientific sense. It is for liver-only resectable metastases patients. It gives a PDL1 & CTLA-4 inhibitors + FOLFOX prior to surgical resection. Goal: To have the immune system wipe up any micro-metastases left over after FOLFOX and surgery. FOLFOX is key to help train the immune system followed by immune activation by anti-PDL1 and anti-CTL4 immnotherapies. NCT02754856

https://clinicaltrials.gov/ct2/show/NCT ... 856&rank=1

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: Baidu [Spider] and 31 guests