AACR-2016 Clinical Trial Post #2: CFI-400945

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AACR-2016 Clinical Trial Post #2: CFI-400945

Postby DK37 » Fri Apr 15, 2016 4:46 pm

AACR-2016 Clinical Trial Post #2: CFI-400945

Clinical trial abstracts of the AACR meeting next week were released this afternoon. AACR presents some clinical trial results - the ASCO conference in June presents much more. A lot of eyes will be on the PD1/Avastin/FOLFOX trial results which will be presented on Monday to see if they mention MSS-CRC. Once I hear feedback what was said, I'll post next week on that one.

Today I'll post (3) clinical trial poster abstracts I noticed with CRC data and with currently open trials.

Title: First-in-human phase I trial of the oral PLK4 inhibitor CFI-400945 in patients with advanced solid tumors

Open Trial: https://clinicaltrials.gov/ct2/show/NCT ... 945&rank=1

Mechanism: oral PLK4 inhibitor (targeted agent)

CRC Data: Two patients enrolled at the 48 mg dose level have completed >6 cycles, including a patient with KRAS mutant colorectal cancer who achieved 24% reduction in target lesions and >50% reduction in serum CEA levels.

Side effects: Some chemo-type side effects

Full abstract: http://www.abstractsonline.com/plan/Vie ... 0fb1922267
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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Nik Colon
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Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: AACR-2016 Clinical Trial Post #2: CFI-400945

Postby Nik Colon » Fri Apr 15, 2016 11:55 pm

Thanks DK :)
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

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