Chemo Question

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chemo sabe
Posts: 444
Joined: Fri Mar 09, 2012 9:01 pm

Re: Chemo Question

Postby chemo sabe » Wed Mar 23, 2016 2:18 pm

The port is not a big deal - I did my first infusion of Oxaliplatin in a vein in my hand. Before it was over, my entire arm was numb. And I mean numb. My wife had to help me with my jacket as I could not feel the arm at all. It was more than a day before it returned to normal.

There are two front line CRC chemo treatments. One is Folfox and the other is Xelox. IMHO - if your Onc has not talked to you about both of them, he or she is very "old school " and I would get a new Onc. One that is younger and in touch with currently approved treatments.
64 year old male
Diagnosed Stage 3 Rectal Cancer - T3N1M0 - Oct 2011
28 radiation treatments with xeloda
Colon resection with ileostomy Feb 2012
8 Rounds of Xelox completed Sept 2012
Ileostomy reversal surgery Oct 2012
Incisional Hernia Repair Nov 2013

macpudd
Posts: 120
Joined: Tue Jul 21, 2015 7:00 pm

Re: Chemo Question

Postby macpudd » Wed Mar 23, 2016 2:23 pm

Hi Mike,
I did not use Xelox, so cannot comment on it. I did have 12 cycles of FolFox, and while I had some problems the port and the pump were the least of them. The port really worked well for me as I had very poor veins because I was in physically bad shape as a result of complications from my surgery. It was not sore when the port was inserted and after the small incision healed I never really noticed it. I also had a PICC line in for some of the time and it was much more bothersome. The pump was a bit of a nusiance, as I found it difficult to sleep for the two nights it was attached, but otherwise it was quite discreet under my clothes, although I did not work while on chemo and was not very physically active either apart from plenty of walking. In my experience it was the side effects of the chemo itself that casued the real problems not the method of delivery. Hope this is some help, and good luck with your treatment.
Regards
Macpudd
Dx 10/13/2014 right hemicolectomy 10/15/2014 pT4b N0 M0
Folfox x12 from Dec 2014 to July 2015
01/16/18 tonic seizure hospital admission
01/17/18 ct and mri 2cm tumor on left side of brain
commenced anti epileptic and steroids and
insulin.
01/25/18 brain craniotomy 80% of tumour removed pathology says gbm4
6 weeks of rad and Temodar chemo and then 6 monthly cycles of Temodar
MRI in Oct no tumor
Mri Jan 2019 tumour growth Feb Pet scan tumour 6cm, no surgery, starting Avastin also Lomustine

mike1965
Posts: 118
Joined: Mon Jan 25, 2016 11:07 pm

Re: Chemo Question

Postby mike1965 » Wed Mar 23, 2016 4:46 pm

Thanks for all the input from everyone. All these decisions are very stressful. So many choices and each choice has its own set of consequences. Plays with your mind and emotions. I will sit down with my oncologist and talk to him about both options.
Colonoscopy 09/06/15 Doctor removed polyp
DX - Rectal cancer 09/10/2015 T1M0N0
Surgeon recommended wait and see approach 09/2015
Tumor board recommended LARs Surgery 10/2015
Oncologist and PCP recommended LARs Surgery 11/2015
Seeking 2nd opinion from another Surgeon 01/2016
Having Sigmoidscopy on 02/01/16.
Figured out treatment 02/2016
LARS Surgery 03/2016
Stage 3A T1 N1C M0
Chemo Folfox to begin 04/18/16

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: Chemo Question

Postby Nik Colon » Wed Mar 23, 2016 6:06 pm

As for the every 2 weeks folfox vs 3 weeks xelox. From what I know, oxi is higher dose on the 3 week schedule (which I would expect due to the time between). You can double check tho. The pump for me was no big deal and did not get in my way even sleeping, the only thing is I didn't shower til it was off, but only 2 days anyway. I got mine every Wednesday morning and disco nurse came to my house Friday morning. I started with the baby bottle size one, later switched to a small ball about half the size. (same amount tho, weird). They give you a fanny pack to carry it in. Again, for me, no big deal at all! Some that have not done it just hated the thought of it, others for other reasons, but if you try it and don't want it, I'm sure you can switch. I also hear more se's from xeloda, but I don't personally know myself. Just a few things you may want to ask about before you decide. Btw, I LOVE my port! I have really bad veins. So anywhere that can access it for any reason, I always have them use it.
Last edited by Nik Colon on Wed Mar 23, 2016 8:48 pm, edited 1 time in total.
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

mike1965
Posts: 118
Joined: Mon Jan 25, 2016 11:07 pm

Re: Chemo Question

Postby mike1965 » Wed Mar 23, 2016 6:36 pm

Nik. Thanks for the info. I have bad veins also so the port sounds like it will be very helpful. They have trouble finding my veins. I will ask the doctor about possible difference in dosage.
Colonoscopy 09/06/15 Doctor removed polyp
DX - Rectal cancer 09/10/2015 T1M0N0
Surgeon recommended wait and see approach 09/2015
Tumor board recommended LARs Surgery 10/2015
Oncologist and PCP recommended LARs Surgery 11/2015
Seeking 2nd opinion from another Surgeon 01/2016
Having Sigmoidscopy on 02/01/16.
Figured out treatment 02/2016
LARS Surgery 03/2016
Stage 3A T1 N1C M0
Chemo Folfox to begin 04/18/16

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: Chemo Question

Postby Nik Colon » Wed Mar 23, 2016 8:54 pm

mike1965 wrote:Nik. Thanks for the info. I have bad veins also so the port sounds like it will be very helpful. They have trouble finding my veins. I will ask the doctor about possible difference in dosage.

Same with me, I tell everyone when they have to "poke me" and I think they don't believe me until they try! Had my colonoscopy yesterday, got poked twice, first on under arm (between wrist and elbow), exploded my hand on 2nd, then got someone else and they got it, yeah, my hand tends to be better, butt... The 3rd and final was in the same hand, different vein. Ugh. Tiny, roll, colapse, etc.
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

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mmblz
Posts: 53
Joined: Sat Oct 10, 2015 3:03 pm

Re: Chemo Question

Postby mmblz » Fri Mar 25, 2016 9:23 am

The port is your friend. Access is SO much easier than getting pricked again each time.
38yo married 14 years. 4 kids 10, 8, 5, 3
2015-09-21 colonoscopy finds tumor in sigmoid, partial obstruction
2015-09-22 CT no mets, path G2 adenocarcinoma, CEA 1.2
2015-09-29 lap hemicolectomy at MSKCC
2015-10-06 pT3 N1a M0 stage IIIB
2015-10-22 folfox started - 12 rounds, last 4 no oxaliplatin
2016-10-27 clear CT !

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Lena
Posts: 165
Joined: Thu Aug 12, 2010 7:10 pm
Facebook Username: Lenarnc
Location: Kentucky

Re: Chemo Question

Postby Lena » Fri Mar 25, 2016 11:27 am

I had a port for my 24/7, 5FU treatment. My chemo/radiation lasted for 6 weeks. They did labs from my port and used it for multiple surgeries. It wasn't too bad. Best of wishes with your treatment.
Dx rectal cancer July 30, 2009
Power port placement Aug. 3, 2009
Chemotherapy/Radiation therapy stated August 3, 2009
Chemo/radiation completed October 4th 2009
Proctocolectomy with Ileoanal jpouch November 3, 2009
NED 2014
Stage 2

Chayo
Posts: 25
Joined: Thu Nov 26, 2015 10:42 pm
Facebook Username: Chayo.ramirez

Re: Chemo Question

Postby Chayo » Sat Mar 26, 2016 7:35 am

I'm headed to the infusion center in just a few minutes to get my 5FU pump disconnected. I've worn it for 4 days and it's been pretty unproblematic. I am only on my 3rd cycle, but I've been able to work with it and most people don't even notice it. In my second cycle I did Xeloda, and I'm just not very good with taking pills on a schedule, so it took a little more thought. Side effects seemed the same.

I have a Groshong catheter rather than an internal port, and they do everything through it. I love it since I was getting sick of getting stuck all the time!
Chayo
Dx 11/24/2015 Colon Cancer at age 45
Adenocarcinoma in the sigmoid colon
12/16/15 colectomy
Stage 2, T3N0
Started Folfiri Feb 1, 2016

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horizon
Posts: 1509
Joined: Tue Apr 12, 2011 10:10 pm

Re: Chemo Question

Postby horizon » Sun Mar 27, 2016 10:02 am

kellywin wrote:Everyone has their own personal choices, it just depends on what works for you.


This is very true. I ended up doing Oxi via a port and Xeloda. With my personality I knew the pump would drive me crazy. It wouldn't be a big deal for others. I didn't mind taking a bunch of pills. It was the right choice for me. You have to decide what's best for you.
I'm just a dude who still can't believe he had a resection and went through chemo (currently 8 years NED). Is this real life?

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juliej
Posts: 3036
Joined: Thu Aug 05, 2010 12:59 pm

Re: Chemo Question

Postby juliej » Mon Mar 28, 2016 8:09 pm

mike1965 wrote:Nik. Thanks for the info. I have bad veins also so the port sounds like it will be very helpful. They have trouble finding my veins. I will ask the doctor about possible difference in dosage.

Mike, make sure you ask for a "PowerPort." It's a special kind of port that can be used for CT scans too so no needle pokes for that either. :D

I took Xeloda rather than using the pump but I had Oxaliplatin and Avastin through my port. That particular combination is called Xelox. As kellywin and horizon said, it's a personal choice, but for me the pills were a lot easier.
Stage IV, liver/lung mets 8/4/2010
Xelox+Avastin 8/18/10 to 10/21/11
LAR, liver resec, HAI pump 11/11
Double lung surgery + ileo reversal 2/12
Adjuvant Xeloda 3-9/12
VATS rt. lung 12/21/12 - benign granuloma!
NED 3/17/12 to 6/13/2019, CEA<1

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horizon
Posts: 1509
Joined: Tue Apr 12, 2011 10:10 pm

Re: Chemo Question

Postby horizon » Mon Mar 28, 2016 9:46 pm

chemo sabe wrote:The port is not a big deal - I did my first infusion of Oxaliplatin in a vein in my hand. Before it was over, my entire arm was numb. And I mean numb. My wife had to help me with my jacket as I could not feel the arm at all. It was more than a day before it returned to normal.


This is similar to what happened to me. They had trouble getting the IV inserted and gave up on one arm and had to switch to another. Did I mention I *hate* needles? Then during the middle of the infusion my arm starts itching and I notice the vein getting red. I had numbness for a day or so. Got a port after that.
I'm just a dude who still can't believe he had a resection and went through chemo (currently 8 years NED). Is this real life?

AppleTree
Posts: 267
Joined: Fri Mar 18, 2016 8:16 am

Re: Chemo Question

Postby AppleTree » Tue Apr 05, 2016 4:27 pm

I just started my 4th week of Xeloda (3000 mg per day, 5 days on/2 off per week). I have been very diligent about using hand cream throughout the day and the foot cream at night. So far my only side effect is being tired...or maybe that is from the radiation. So far my chemo DR is pleased that I am handling it well. Radiation is a bit more bumpy, but I am in the home stretch now. 1.5 more weeks to go. Whatever you choose, hopefully the time will go fairly fast for you. For me, one day just seems to blend in with another and now I am almost done with this bit.
Diag Feb 5, 2016 Age 45
3 cm tumor 5 cm from verge
Radiation + Xeloda pills - 3000mg 5x week
3/14 - 4/16 - 25 sessions
Shrank just over 50% L nodes 0/13
Remove rectum with temp Ileo 6/17
Reversal 7/20 due to infection
Acute hepatitis August. Chemo cancelled
June to September 2016 - 58 days in hospital

2017
6/16, MRI shadow in lung
Pet - 6.6mm Met in Upper R lobe
7/30 VAT surgery Mass General/Boston
8/24 port
8/30 - 4/28 Folfox. 12 rounds
2018
June CT shows new lung Mets.
July/Oct PETs...CLEAR!


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