MSS Trial: Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab)

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DK37
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Location: San Diego

MSS Trial: Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab)

Postby DK37 » Sat Mar 19, 2016 7:25 am

Here is a MSS Trial that has been open for awhile but I don't see a post from me listing it (unless I'm blind always possible :) )
It combines Anti-CD27 (Varlilumab) with Anti-PD-1 (Nivolumab).
There is good preclinical data in mice and I have heard some recent (unconfirmed) buzz on this one. It has sites nationwide.

https://clinicaltrials.gov/ct2/show/NCT02335918

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

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chrissyrice
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Location: Atlanta, Georgia

Re: MSS Trial: Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab)

Postby chrissyrice » Sat Mar 19, 2016 11:21 am

:D

Thank you, Tom.

Adding to my list of future possible treatments :wink:

Chrissy
DX 10-31-09 Surgery 12-1-09 Sigmoid Colon
Stage IIIb T3,N2,MX; Chemo Feb 2010-Aug 2010; 4 rounds Folfox; 8 rounds 5FU +LV
12/2010 PET/CT Scan, Cancer Free
7/2012 CT Scan NED 2 years
10/2013 NED 3 years
8/2014 NED 4 years
Recurrence 6/2015: iliac lymph node(s)
8/2015 Surgery: 3 cm tumor removed+iliac artery graft
3/2016 CT Scan Stable
6/2016 Stable
9/2016 Stable
12/2016 Stable
3/2017 Stable
Recurrence 6/2017
12/2017 Surgery removed all cancer w/ clean margins
07-27-2018 Cancer-free for 7 months

Snapfish
Posts: 50
Joined: Mon Oct 05, 2015 10:42 pm
Location: Washington, DC (dad in Houston, TX)

Re: MSS Trial: Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab)

Postby Snapfish » Sun Mar 20, 2016 8:09 pm

Thanks, Tom!
Daughter to 70-year old father dx 2015-Sept-28: Stage IV adenocarcinoma with signet ring cell features
Sigmoid colon primary with peri mets
MSS; RAS wild-type; mutation in exon 8 of p53

2015-Oct: Began FOLFOX-6 at MDA; CEA was 15.1 at baseline
2016-Feb: CEA 5.7; 10 full rounds of FOLFOX-6 completed
2016-Mar-3: Began FOLFIRI
chemo, chemo, chemo
2017-Jan: Total of 29 cycles of chemo down. Back on FOLFOX again after FOLFIRI fail. CEA now 118.

Stanfordmom
Posts: 613
Joined: Wed May 14, 2014 1:32 am

Re: MSS Trial: Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab)

Postby Stanfordmom » Tue Jun 14, 2016 12:30 pm

Hi Tom,

Do you know if this trial might work for KRAS mutant mCRC?

Thank you so much,

Sha
DX 4/2/2014 at 44, stage 4, mets liver and ovaries
Mom to 2 boys
Three surgeries, HAI pump and lots of chemo
fighting!

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: MSS Trial: Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab)

Postby DK37 » Wed Jun 15, 2016 6:46 am

Stanfordmom wrote:Hi Tom,

Do you know if this trial might work for KRAS mutant mCRC?

Thank you so much,

Sha


Hi Sha,

The trial's inclusion criteria does not mention KRAS=status, this implies that they feel a similar response is possible whether a patient is KRAS-mutant or KRAS-wildtype.

DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List


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