New MSS Trial: anti-CSF1R "AMG 820" + anti-PD1

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DK37
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New MSS Trial: anti-CSF1R "AMG 820" + anti-PD1

Postby DK37 » Sat Mar 19, 2016 7:16 am

Here is a new PD-1 immunotherapy combination trial about to open. It alllows MSS-CRC patients. It combines a "anti-CSF1R" drug called "AMG 820" with an anti-PD-1 drug. It uses the same strategy as the "FPA008" trial previously posted (so just search for that name or look in my signature line hyperlink) and a few months ahead of it in development. The anti-CSF1R is intended to removed immunosuppresive "tumor associated macrophages" from the tumor to make it "hotter" and more prone to T-Cell attack after PD-1 inhibition. Trial locations have not been announced yet but it will be a big trial - so there will be multiple locations nationwide

https://clinicaltrials.gov/ct2/show/NCT ... 529&rank=1

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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chrissyrice
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Joined: Thu Sep 23, 2010 8:44 am
Location: Atlanta, Georgia

Re: New MSS Trial: anti-CSF1R "AMG 820" + anti-PD1

Postby chrissyrice » Sat Mar 19, 2016 11:18 am

:D

Thanks for the info!
DX 10-31-09 Surgery 12-1-09 Sigmoid Colon
Stage IIIb T3,N2,MX; Chemo Feb 2010-Aug 2010; 4 rounds Folfox; 8 rounds 5FU +LV
12/2010 PET/CT Scan, Cancer Free
7/2012 CT Scan NED 2 years
10/2013 NED 3 years
8/2014 NED 4 years
Recurrence 6/2015: iliac lymph node(s)
8/2015 Surgery: 3 cm tumor removed+iliac artery graft
3/2016 CT Scan Stable
6/2016 Stable
9/2016 Stable
12/2016 Stable
3/2017 Stable
Recurrence 6/2017
12/2017 Surgery removed all cancer w/ clean margins
07-27-2018 Cancer-free for 7 months


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