New MSS Trial: anti-CSF1R "AMG 820" + anti-PD1

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DK37
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Location: San Diego

New MSS Trial: anti-CSF1R "AMG 820" + anti-PD1

Postby DK37 » Sat Mar 19, 2016 7:16 am

Here is a new PD-1 immunotherapy combination trial about to open. It alllows MSS-CRC patients. It combines a "anti-CSF1R" drug called "AMG 820" with an anti-PD-1 drug. It uses the same strategy as the "FPA008" trial previously posted (so just search for that name or look in my signature line hyperlink) and a few months ahead of it in development. The anti-CSF1R is intended to removed immunosuppresive "tumor associated macrophages" from the tumor to make it "hotter" and more prone to T-Cell attack after PD-1 inhibition. Trial locations have not been announced yet but it will be a big trial - so there will be multiple locations nationwide

https://clinicaltrials.gov/ct2/show/NCT ... 529&rank=1

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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chrissyrice
Posts: 1151
Joined: Thu Sep 23, 2010 8:44 am
Location: Atlanta, Georgia

Re: New MSS Trial: anti-CSF1R "AMG 820" + anti-PD1

Postby chrissyrice » Sat Mar 19, 2016 11:18 am

:D

Thanks for the info!
Dx 10-31-09 Surgery 12-1-09 Sigmoid Colon Stage IIIb; Chemo Feb 2010-Aug 2010; 4 rounds Folfox; 8 rounds 5FU & Leucovorin;12-16-2010 PET/CT Scan Cancer Free;7-05-2012 CT Scan NED 2 years;10-13-2013 NED 3 yrs; 08-01-2014 NED 4 yrs; 06-30-2015 Stage 4 iliac lymph node(s) 08-11-2015 Surgery 3 cm tumor and iliac artery graft done. Positive margins in the abdominal aorta, No chemo. 03-16-2016 CT Scan Stable,06-16-2016 CT Scan Stable,09-21-2016 CT Scan Stable,12-2016 Stable,03-31-17 Stable,
Recurrence 6-30-17


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