guys anything on this ?
http://www.techtimes.com/articles/12375 ... ofenac.htm
just google and you will find the medication name is Diclofenac linked to NLRX1 protein.
mariane wrote:Ieowi,
I lately learnt that the mutation your dad and I hold FBXW7 is highly immunogenic. He is also MSI low. Considering all this I think there is a good chance he might respond to immunotherapy meds.
mariane wrote:http://www.medscape.com/viewarticle/859945?src=wnl_edit_tpal&uac=165533BX#vp_2
"However, mutations in FBXW7 were associated with the absence of metastases and were seen in M0 patients across cohorts. This correlated with increased expression of T-cell proliferation and antigen-presenting functions. Dr Fox said that mutated FBXW7 increases inflammatory signaling, thereby boosting the immune response."
All the info about significance of this mutation as triggering immune response are relatively new, hard to find.
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