MSS-CRC Immunotherapy Trial: AM0010

Please feel free to read, share your thoughts, your stories and connect with others!
User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

MSS-CRC Immunotherapy Trial: AM0010

Postby DK37 » Wed Feb 10, 2016 5:07 pm

This is a MSS-CRC immunotherapy trial with a FOLFOX + Immunotherapy arm. Unfortunately the PD-1 combo arm is not open to CRC patients at this time. (updated info thanks to a friend of mine who called!)

http://www.fiercebiotech.com/story/celg ... 2016-02-10

Here is the AM0010 clinical trial, multiple sites nationwide: https://clinicaltrials.gov/ct2/show/NCT ... 010&rank=1

-DK
Last edited by DK37 on Thu Feb 11, 2016 10:37 am, edited 1 time in total.
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

User avatar
vilca11
Posts: 730
Joined: Fri Feb 14, 2014 11:19 am
Location: Moscow, Russia; Baltimore, USA 1992; Vilcabamba, Ecuador 2012

Re: MSS-CRC Immunotherapy Trial: AM0010 + Now Adding PD-1

Postby vilca11 » Thu Feb 11, 2016 12:17 am

Thank you, dear Tom, could be a good one.... Read your last blog about the little number... we have a "similar schedule" with you - mine is having a trend up too, and scan is next week too... darn thing just throws any logic down the drain... Anyway, just wanted to shake your hand today, after reading the blog...
Hugs, love and gratitude your way, sweetheart... stella
11/2005 CC stage 1, F,50yo@dx
Mod dif adenocar, MSS, APC, TP53, CEAs1.6-4.8
1/12 1met liver@Vena Cava, RFA, 3oxi,11 5FU
8/13 2 mets same place,SBRT
4/14 2 Xeliri+Avastin
5/14 Nano Knife liver same 2 mets
6/14 2 Xeliri, ADAPT
4/15 PET, 2 same mets,Cryo Liver
5/15 MJ Oil, Herbs, Suppl, ADAPT
10/15 PET, same area, doubled in size, high SUV
10/15 RH, HAI, visceral involv., no LN
2/16 red FF, 50% red dose FUDR, CEA trends up
3/16 CT, PET, MRI L.Lobe all in small tumors
4/16 No acceptable options, going home

Stanfordmom
Posts: 613
Joined: Wed May 14, 2014 1:32 am

Re: MSS-CRC Immunotherapy Trial: AM0010 + Now Adding PD-1

Postby Stanfordmom » Thu Feb 11, 2016 2:17 am

Tom,

Thanks for sharing. This one seems promising!
DX 4/2/2014 at 44, stage 4, mets liver and ovaries
Mom to 2 boys
Three surgeries, HAI pump and lots of chemo
fighting!

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: MSS-CRC Immunotherapy Trial: AM0010 + Now Adding PD-1

Postby DK37 » Thu Feb 11, 2016 10:36 am

vilca11 wrote:Thank you, dear Tom, could be a good one.... Read your last blog about the little number... we have a "similar schedule" with you - mine is having a trend up too, and scan is next week too... darn thing just throws any logic down the drain... Anyway, just wanted to shake your hand today, after reading the blog...
Hugs, love and gratitude your way, sweetheart... stella


Thanks Vilca :)
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: MSS-CRC Immunotherapy Trial: AM0010

Postby DK37 » Thu Feb 11, 2016 10:38 am

Updated Post title & info-

Unfortunately the PD-1 combo arm is not open to CRC patients at this time. (updated info thanks to a friend of mine who called!) - just the FOLFOX combo arms.

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: Bing [Bot], Yahoo [Bot] and 31 guests