New MSS-CRC Immunotherapy Trial: JNJ-61610588 (anti-VISTA)

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DK37
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New MSS-CRC Immunotherapy Trial: JNJ-61610588 (anti-VISTA)

Postby DK37 » Sat Feb 06, 2016 10:46 am

This new immunotherapy trial that has an arm that appears to be open to all subtypes of CRC.

The target is a different checkpoint inhibitor target than PD-1 called "VISTA". This is the first anti-VISTA drug to enter clinical trials. It's code name is "JNJ-61610588" and the clinical trial is NCT02671955. It looks like they will have (4) trial site for now: NY, TN, NC, PA.

https://clinicaltrials.gov/ct2/show/NCT02671955

I also linked a preclinical review of VISTA where they focused on lung cancer and CRC.

http://www.ncbi.nlm.nih.gov/pubmed/24894088

This is a monotherapy trial - I suspect its activity could be highest as a combo with PD-1 but as the very first VISTA inhibitor to enter clinical trials - we are all learning together. It is interesting that they have not planned a PD-1 combo expansion arm..... could be for efficacy reasons or safety reasons or some other reason - hard to know...

Immunotherapy science marches on!

-DK
Last edited by DK37 on Wed Aug 03, 2016 6:12 am, edited 2 times in total.
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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Stanfordmom
Posts: 613
Joined: Wed May 14, 2014 1:32 am

Re: New MSS-CRC Immunotherapy Trial: JNJ-61610588 (anti-VISTA)

Postby Stanfordmom » Sat Feb 06, 2016 6:01 pm

Thanks for sharing! Promoting progress in the immunotherapy area. I so hope they find something working great for CRC!

Sha
DX 4/2/2014 at 44, stage 4, mets liver and ovaries
Mom to 2 boys
Three surgeries, HAI pump and lots of chemo
fighting!


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