New Column & Blog Post - Personalized Immunotherapy: Therapeutic Vaccines

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

New Column & Blog Post - Personalized Immunotherapy: Therapeutic Vaccines

Postby DK37 » Thu Feb 04, 2016 6:59 pm

I have two new posts to share today - both have to do with what I consider very a exciting new immunotherapy technology starting to enter into Phase 1 trials: Personalized Therapeutic Vaccines.

The first is my monthly The Currently Incurable Scientist science column which goes over the basics: http://fightcolorectalcancer.org/resear ... -vaccines/

As a follow-up to this column, I also wrote a new personal blog post further detailing personalized immuntherapy vaccines – the science, the excitement and the urgent need! http://adventuresinlivingterminallyopti ... notherapy/

From the blog: “…If the possibility of a solid tumor cure is dependent on it – what could be more incentive to engineers to figure things out than that? Disruptive technologies are always hard but when they offer something previously unobtainable (and desperately sought after) – they lead and the world follows.

I can’t accurately predict if a personalized cancer therapeutic vaccine will eventually cure anyone’s cancer – since by definition, science is all about pushing the boundaries of knowledge & attempting the currently unknown. What I can say though is that many scientific and engineering stars are aligning for the very first time to make a strong shot on that goal using this strategy. As a scientist-patient-advocate that is what I am looking for – for myself & others. Strong shots on goal. I need it, my fellow cancer patient community needs it, and the world needs it.”

My personal opinion is that I honestly think the best shot at maximizing immunotherapy response rates will involve a mixture of teaching the immune system + activating it. Keep an eye on this technology. Hopefully it works-

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

jortego128
Posts: 288
Joined: Sat Aug 15, 2015 7:47 am

Re: New Column & Blog Post - Personalized Immunotherapy: Therapeutic Vaccines

Postby jortego128 » Thu Feb 04, 2016 9:50 pm

I posted about a phase 1 personalized peptide vaccine trial starting at MDA this coming March a while back. Wasnt sure you'd seen it!

viewtopic.php?f=1&t=53371&p=422309#p422309

https://clinicaltrials.gov/ct2/show/NCT ... ma&rank=11
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016


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