BBI-608 Clinical Trial Update

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BBI-608 Clinical Trial Update

Postby DK37 » Thu Jan 28, 2016 4:06 pm

A trial to consider while waiting for the immunotherapy rocket to take off... On clinicaltrials .gov or Chris4Life DATABLUE search for "BBI-608" for active studies. At ASCO-GI last weekend it was a small trial but they saw activity in >50% of heavily pre-treated patients as an add-on to standard chemotherapy, including in patients who had previously failed that chemotherapy.

News Article: ... tal-cancer
ASCO-GI Abstract:

6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder:
2016 Colondar 2.0 Model
DK37 Science Posts List

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Re: BBI-608 Clinical Trial Update

Postby Stanfordmom » Thu Jan 28, 2016 9:05 pm

Thank you so much, DK, for keeping us updated with all the exciting immunotherapy trials.

DX 4/2/2014 at 44, stage 4, mets liver and ovaries
Mom to 2 boys
Three surgeries, HAI pump and lots of chemo

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Re: BBI-608 Clinical Trial Update

Postby Steph20021 » Thu Jan 28, 2016 9:18 pm

DK, thank you for sharing.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
01/17- pulmonary embolism
02/17- 1 wk radiation to abdo wall
08/16- on folfiri
11/18- Beacon trial-encorafenib & cetuximab

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Re: BBI-608 Clinical Trial Update

Postby EverySunriseCounts » Thu Jan 28, 2016 10:20 pm

Thanks DK. And "while waiting for the immunotherapy rocket to take off"--thanks also for that turn of phrase!
We have a couple of newbies who need to hear it, I think...
-Diagnosed with Stage IV CRC 09/14, liver,lymph mets
-Started Folfox
- Emergency surgery 10/14, removed colon tumor, temp ileostomy
- New abdominal tumor 05/15 changed to Folfiri
- Added Avastin 09/15
- Stable scan (liver mets still present) 11/15
- Stable scan 02/16; chemo halted 03/25
-Ostomy reversal 05/16

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Re: BBI-608 Clinical Trial Update

Postby Mastan » Fri Jan 29, 2016 2:04 pm

Hi DK37,

Thanks for the encouraging news on this trial. I had considered it once but there was no info as to its effectiveness at the time. Looks like it is time to reconsider the trial.

Dx 6/2010 rectal CA

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