NEJM: Potential Stage 2 CRC Biomarker for Chemotherapy Use

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

NEJM: Potential Stage 2 CRC Biomarker for Chemotherapy Use

Postby DK37 » Fri Jan 22, 2016 7:35 am

A potentially very important new finding showing a biomarker that appears predictive of Stage 2 patients that would significantly benefit from chemotherapy. Findings were based upon retrospective analysis, prospective clinical trials have not been done yet. First link = news article. Second link = article from the New England Journal of Medicine. http://www.medscape.com/viewarticle/857470 and http://www.nejm.org/doi/full/10.1056/NEJMoa1506597

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: NEJM: Potential Stage 2 CRC Biomarker for Chemotherapy Use

Postby Nik Colon » Fri Jan 22, 2016 7:11 pm

Just wanted to say hi, and thanks again for all your info. I see you're keeping your list updated :) Thanks again for all you do.

Nik
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: NEJM: Potential Stage 2 CRC Biomarker for Chemotherapy Use

Postby DK37 » Fri Jan 22, 2016 10:57 pm

Nik Colon wrote:Just wanted to say hi, and thanks again for all your info. I see you're keeping your list updated :) Thanks again for all you do.

Nik


Hi Nik! I thought of you this morning when I was adding this link to my list you started! :-)

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

User avatar
Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: NEJM: Potential Stage 2 CRC Biomarker for Chemotherapy Use

Postby Nik Colon » Fri Jan 22, 2016 11:31 pm

DK37 wrote:
Nik Colon wrote:Just wanted to say hi, and thanks again for all your info. I see you're keeping your list updated :) Thanks again for all you do.

Nik


Hi Nik! I thought of you this morning when I was adding this link to my list you started! :-)

-DK

:mrgreen: hope you are doing well :)
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

orcasres
Posts: 836
Joined: Mon Jul 01, 2013 10:23 pm
Location: Orcas Island, WA

Re: NEJM: Potential Stage 2 CRC Biomarker for Chemotherapy Use

Postby orcasres » Sat Jan 23, 2016 1:54 am

DK,

Thanks so much for posting this. I was staged IIA but I got adjuvant chemo because my tumor was medullary which is rare and I had lymphovascular invasion. The medullary tumor was the driver. I just pulled my pathology report and I was CDX2 positive. While I have a number of residual side effects from the chemo and I wanted to take every step I could to keep the disease from returning (I never regretted doing it), I wonder with this study if it would have been recommended. I am thrilled to see this kind of research. It certainly seems like it will put another tool in the box for stage II folks.

Lois
63 yo F
Colon resection Sept. 2010
pT3N0M0 Stage 2A
Medullary Tumor 6.5cm long
Lymphovascular invasion
Lynch negative
12 FOLFOX 11/2010 to 5/2011 8 w/Oxi
NED so far


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