My last weeks Ct came back with this news
" There is a new micronodular pattern of ill-defined soft tissue in the anterior mesentery consistent with peritoneal carcinomatosis "
Onc mentioned growths in abdominal walls & switched treatment from FLOFOX to FLOFRI.
Did a bit of research into peritoneal & it sounds like a common progression of CRC, but that chemo has little effect on it .
Anyone have any insights ?
peritoneal activity
peritoneal activity
Sept 2014 DX Stage4 Colon w. Met liver, Lung & Lymph nodes
Tumor removed was obstructing sigmoid colon
Dec 2014 Start Capox 1800 Xeloda /2 day
April 2015 Switched to Flofox , after 6 months stomach could not tolerate Xeloda, rapid weight loss, stopped eating
Flofox MUCH easier on digestive system, every Nurse after switch said " no one handles Xeloda well "
2015 Dec CT finds Peritoneal lining mets so switched from Oxaliplatin to Irinotecan ( Camposar)
Tumor removed was obstructing sigmoid colon
Dec 2014 Start Capox 1800 Xeloda /2 day
April 2015 Switched to Flofox , after 6 months stomach could not tolerate Xeloda, rapid weight loss, stopped eating
Flofox MUCH easier on digestive system, every Nurse after switch said " no one handles Xeloda well "
2015 Dec CT finds Peritoneal lining mets so switched from Oxaliplatin to Irinotecan ( Camposar)
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Steph20021
- Posts: 553
- Joined: Sat Dec 27, 2014 4:58 pm
- Location: Ontario, Canada
Re: peritoneal activity
Find out if you are a hipec surgery candidate. If they don't do hipec in sask they can send you to BC or Ontario (mount Sinai/pmh).
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, NED
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
01/17- pulmonary embolism
02/17- 1 wk radiation to abdo wall
08/16- on folfiri
01/18-folfox
11/18- Beacon trial-encorafenib & cetuximab
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, NED
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
01/17- pulmonary embolism
02/17- 1 wk radiation to abdo wall
08/16- on folfiri
01/18-folfox
11/18- Beacon trial-encorafenib & cetuximab
Re: peritoneal activity
I have ongoing peri mets. I have had them removed via surgery, I have also had them surgically removed in conjunction with HIPEC. HIPEC is the gold standard for treating peri mets, and can be curative for some. It didn't work for me, however we are currently managing my disease with a combination of chemo and surgery. Chemo has worked on my peri mets, both in shrinking them/keeping things stable. However, it is commonly reported to not be particularly effective for some patients. Everyone's experience is unique, it seems. My advice would be to consult with a surgical oncologist who specializes in HIPEC, to determine if you would be a candidate for that procedure. It's tough, but probably your best bet. Best of luck to you!
stg IV 4/2013 @34 - liver, ovary/peritoneum
Lots of chemo, surgery and good luck - still doing well 03/2016...
Lots of chemo, surgery and good luck - still doing well 03/2016...
Re: peritoneal activity
Asked Onc about HIPEC.
He said my other mets cause me to not be a candidate.
Mentioned a high mortality rate of the surgery & a lot of complications.
I will have to do more research, his response seemed to be overly simple.
Thanks
He said my other mets cause me to not be a candidate.
Mentioned a high mortality rate of the surgery & a lot of complications.
I will have to do more research, his response seemed to be overly simple.
Thanks
Sept 2014 DX Stage4 Colon w. Met liver, Lung & Lymph nodes
Tumor removed was obstructing sigmoid colon
Dec 2014 Start Capox 1800 Xeloda /2 day
April 2015 Switched to Flofox , after 6 months stomach could not tolerate Xeloda, rapid weight loss, stopped eating
Flofox MUCH easier on digestive system, every Nurse after switch said " no one handles Xeloda well "
2015 Dec CT finds Peritoneal lining mets so switched from Oxaliplatin to Irinotecan ( Camposar)
Tumor removed was obstructing sigmoid colon
Dec 2014 Start Capox 1800 Xeloda /2 day
April 2015 Switched to Flofox , after 6 months stomach could not tolerate Xeloda, rapid weight loss, stopped eating
Flofox MUCH easier on digestive system, every Nurse after switch said " no one handles Xeloda well "
2015 Dec CT finds Peritoneal lining mets so switched from Oxaliplatin to Irinotecan ( Camposar)
-
Steph20021
- Posts: 553
- Joined: Sat Dec 27, 2014 4:58 pm
- Location: Ontario, Canada
Re: peritoneal activity
CM35 wrote:I have ongoing peri mets. I have had them removed via surgery, I have also had them surgically removed in conjunction with HIPEC. HIPEC is the gold standard for treating peri mets, and can be curative for some. It didn't work for me, however we are currently managing my disease with a combination of chemo and surgery. Chemo has worked on my peri mets, both in shrinking them/keeping things stable. However, it is commonly reported to not be particularly effective for some patients. Everyone's experience is unique, it seems. My advice would be to consult with a surgical oncologist who specializes in HIPEC, to determine if you would be a candidate for that procedure. It's tough, but probably your best bet. Best of luck to you!
What kind of chemo have you had and which is working for you?
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, NED
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
01/17- pulmonary embolism
02/17- 1 wk radiation to abdo wall
08/16- on folfiri
01/18-folfox
11/18- Beacon trial-encorafenib & cetuximab
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, NED
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
01/17- pulmonary embolism
02/17- 1 wk radiation to abdo wall
08/16- on folfiri
01/18-folfox
11/18- Beacon trial-encorafenib & cetuximab
Re: peritoneal activity
6 months CAPOX
6 Months FLOFOX
liver tumors died somewhere in there , but lung mets multiplied into the hundreds. So hard to tell what worker & didn't.
Now peritoneal lining mets are the latest change.
6 Months FLOFOX
liver tumors died somewhere in there , but lung mets multiplied into the hundreds. So hard to tell what worker & didn't.
Now peritoneal lining mets are the latest change.
Sept 2014 DX Stage4 Colon w. Met liver, Lung & Lymph nodes
Tumor removed was obstructing sigmoid colon
Dec 2014 Start Capox 1800 Xeloda /2 day
April 2015 Switched to Flofox , after 6 months stomach could not tolerate Xeloda, rapid weight loss, stopped eating
Flofox MUCH easier on digestive system, every Nurse after switch said " no one handles Xeloda well "
2015 Dec CT finds Peritoneal lining mets so switched from Oxaliplatin to Irinotecan ( Camposar)
Tumor removed was obstructing sigmoid colon
Dec 2014 Start Capox 1800 Xeloda /2 day
April 2015 Switched to Flofox , after 6 months stomach could not tolerate Xeloda, rapid weight loss, stopped eating
Flofox MUCH easier on digestive system, every Nurse after switch said " no one handles Xeloda well "
2015 Dec CT finds Peritoneal lining mets so switched from Oxaliplatin to Irinotecan ( Camposar)
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michellecairn
- Posts: 80
- Joined: Wed Dec 23, 2015 7:09 pm
- Facebook Username: Michelle Pulera
- Location: Kenosha, Wisconsin
Re: peritoneal activity
I too have perinoteal carcinomatos. Chemo didn't work on my mets. I had 1 round of FOLFIRINOX/5FU but had a reaction to the irinotecan. I then did 5 rounds of FOLFOX/5FU with the last 4 rounds having Avastin added.
I've seen 3 different oncologists in the last month and none of them are willing to do any type of surgery on me. They don't think it would be beneficial in my case - maybe because I'm already stage IV. I've been asking about HIPEC since I started chemo, but they keep telling me no.
We all react differently to treatments - I'm hoping that you find one that will work on your perinoteal mets. Best wishes to everyone.
I've seen 3 different oncologists in the last month and none of them are willing to do any type of surgery on me. They don't think it would be beneficial in my case - maybe because I'm already stage IV. I've been asking about HIPEC since I started chemo, but they keep telling me no.
We all react differently to treatments - I'm hoping that you find one that will work on your perinoteal mets. Best wishes to everyone.
Age: 39(38 at dx), married, mom of 2
Stage IV
DX: 10-7-15 colon cancer (signet ring cell)
CEA: 10-4-15: 9.5, 2-8-16: 42.5, 3-7-16: 22.6, 5-26-16: 18.8, 7-27-16: 14.3, 10-20-16: 21.1
abnormal MSH6 and BARD1
KRAS: wild type
MSI High
Lynch positive
11-16-15: 1 round Folfirinox/5FU, 5 rounds folfox/5FU , 4 with Avastin
2-8-16: Chemo not working
3-7-16: back to folfox/Avastin/5FU
3-24-16: Keytruda
2-23-17: FAILED Keytruda
3-2-17: Erbitux
3-30-17: Erbitux + Irinotecan
5-25-17: FAILED Erbitux + Irinotecan
Stage IV
DX: 10-7-15 colon cancer (signet ring cell)
CEA: 10-4-15: 9.5, 2-8-16: 42.5, 3-7-16: 22.6, 5-26-16: 18.8, 7-27-16: 14.3, 10-20-16: 21.1
abnormal MSH6 and BARD1
KRAS: wild type
MSI High
Lynch positive
11-16-15: 1 round Folfirinox/5FU, 5 rounds folfox/5FU , 4 with Avastin
2-8-16: Chemo not working
3-7-16: back to folfox/Avastin/5FU
3-24-16: Keytruda
2-23-17: FAILED Keytruda
3-2-17: Erbitux
3-30-17: Erbitux + Irinotecan
5-25-17: FAILED Erbitux + Irinotecan
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jillbugs4110
- Posts: 266
- Joined: Thu Jul 31, 2014 3:36 pm
Re: peritoneal activity
Me too big fat no for HIPEC they say to risky
Live One Day At A Time
I Abandon myself to God
46 6 yo.....9yo...
stage 1V liver mets
my one prayer to got to sustain me to raise my two babies this is my only wish then take me out if needed.
I Abandon myself to God
46 6 yo.....9yo...
stage 1V liver mets
my one prayer to got to sustain me to raise my two babies this is my only wish then take me out if needed.
Re: peritoneal activity
Thanks for the replys, every one adds a little more knoledge
Sept 2014 DX Stage4 Colon w. Met liver, Lung & Lymph nodes
Tumor removed was obstructing sigmoid colon
Dec 2014 Start Capox 1800 Xeloda /2 day
April 2015 Switched to Flofox , after 6 months stomach could not tolerate Xeloda, rapid weight loss, stopped eating
Flofox MUCH easier on digestive system, every Nurse after switch said " no one handles Xeloda well "
2015 Dec CT finds Peritoneal lining mets so switched from Oxaliplatin to Irinotecan ( Camposar)
Tumor removed was obstructing sigmoid colon
Dec 2014 Start Capox 1800 Xeloda /2 day
April 2015 Switched to Flofox , after 6 months stomach could not tolerate Xeloda, rapid weight loss, stopped eating
Flofox MUCH easier on digestive system, every Nurse after switch said " no one handles Xeloda well "
2015 Dec CT finds Peritoneal lining mets so switched from Oxaliplatin to Irinotecan ( Camposar)
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