CLINICAL TRIALS and Important Links

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CRguy
Posts: 9133
Joined: Sun Feb 10, 2008 6:00 pm

CLINICAL TRIALS and Important Links

Postby CRguy » Tue Dec 08, 2015 9:40 pm

Dear ColonTalk Forum Members :

We are anchoring this topic to act as an ongoing resource of important links, and as requested, all of our links to Clinical Trials are now being listed here as a permanent index.

The impetus for this was from the topic Clinical Trial Information started by our dear friend lilacbreastedroller,
who sadly, is no longer with us ( lilacbreastedroller has earned her wings )


Please note :

All individual discussions should be started on the regular forum so this topic remains JUST as an index of important links.
It will be curated much like our ongoing 2009- 2016 "In Memoriam" topic and ***News Stories Thread*** ONGOING 2016.

Any member who wishes to post a link here may do so as long as the format is consistent :
Subject = the name of the link or trial
body of the post = an active link to the site or clinical trail and a brief description.

The first listing will be an example, but PM me if you have any problems.

Best wishes all and let's get those links OUT THERE !

Cheers
CRguy

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CRguy
Posts: 9133
Joined: Sun Feb 10, 2008 6:00 pm

Cancer Immunotherapy Clinical Trials

Postby CRguy » Tue Dec 08, 2015 9:42 pm

Cancer Research Institute has posted a list Cancer Immunotherapy Clinical Trials

and an interactive trial finder Here

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CRguy
Posts: 9133
Joined: Sun Feb 10, 2008 6:00 pm

DK37 Science Posts List

Postby CRguy » Tue Dec 08, 2015 10:00 pm

Our own member DK37 will update his list of Science Posts HERE
to keep his research investigations current for both basic science as well as new CRC clinical trials.

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Mastan
Posts: 433
Joined: Sat Feb 19, 2011 11:12 am
Location: Albuquerque, NM

Re: CLINICAL TRIALS and Important Links

Postby Mastan » Wed Dec 09, 2015 11:00 am

Keep up the good work on this important topic.

Thanks,

Mark
Dx 6/2010 rectal CA

bitchslapped
Posts: 1280
Joined: Tue Sep 09, 2014 3:23 pm
Location: PNW/USA

Re: CLINICAL TRIALS and Important Links

Postby bitchslapped » Fri Dec 11, 2015 9:22 pm

STANDARD OF CARE-
National Comprehensive Cancer Network (NCCN):
Downloadable guideline for standard of care
http://www.nccn.org/patients/guidelines ... aspx#colon


Clinical versions are also available here :
https://www.tri-kobe.org/nccn/guideline/colorectal/english/rectal.pdf
https://www.tri-kobe.org/nccn/guideline/colorectal/english/colon.pdf


SUPPORT RESOURCES (financial, travel, lodging, etc)-
Lynch Syndrome International
"Hover" over Resource page (not just for Lynch patients)
http://lynchcancers.com/

Michael's Mission (The Colon Club partner):
http://www.michaelsmission.org/resources-library/

http://www.needhelppayingbills.com/index.html

National Association of Healthcare Advocacy Consultants (private, fee-based personal care management)
http://nahac.memberlodge.com/

Patient Advocate Foundation (free)-
http://www.patientadvocate.org/


CLINICAL TRIALS GLOBAL DATABASE-

CenterWatch
Publishing/information services listing of institutional review board (IRB)-approved clinical trials.
http://www.centerwatch.com/clinical-trials/listings/

U.S. National Institutes of Health (NIH), (private & public sponsored)
https://www.clinicaltrials.gov/

National Cancer Institute (NCI), (U.S., Canada)
http://www.cancer.gov/about-cancer/trea ... als/search


CLINICAL TRIAL MATCH UP SERVICES (phone support)-

Paid by their sponsors/partners @ no cost to the public

American Cancer society (Global)
Partnered w/eviti clinical trial finder database (software for clinicians)
http://www.cancer.org/treatment/treatme ... find-trial

Emergingmed (U.S., Canada) Many websites (including Foundation Medicine/Foundation One) have partnered with this designer of clinical trial finders:
https://www.emergingmed.com/pub_home_page.asp

From our own Colon Club partner Michael's Mission (U.S.)-
http://curelauncher.com/

National Cancer Institute (NCI), (U.S)
Will provide contacts to clinical trial navigators globally
http://www.cancer.gov/contact
Last edited by bitchslapped on Sun Sep 04, 2016 10:59 pm, edited 4 times in total.
DSS,35YO,unresect mCRC DX 7/'14,lvr,LN,peri,rib
FOLFOX+Avstn 4 Rnds d/c 10/'14
Stent 9/'14
FOLFIRI+Avstn 10/'14
Gone From My Sight 2/20/15
Me:garden variety polyps + precancerous polyp
Carergver x2 DH,DM dbl occupancy,'03-'10
DH dx 47YO mCRC,'04-'07 fried x HAI
DM dx CC 85YO,CC,CHF,stroke,dementia,aphasia

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O Stoma Mia
Posts: 802
Joined: Sat Jun 22, 2013 6:29 am

Why Should I Participate in a Clinical Trial?

Postby O Stoma Mia » Tue Dec 15, 2015 10:30 am

Why Should I Participate in a Clinical Trial?
http://www.nih.gov/health-information/nih-clinical-research-trials-you/why-should-i-participate-clinical-trial

Benefits and risks of clinical trials

The decision to join a clinical trial is similar to making decisions about other aspects of your treatment. There are both pros and cons associated with clinical trials. Some people decide that there are too many risks, while others decide that they are willing to take those risks to try a new treatment.

Here is how participating in a clinical trial can help you:

You may gain access to new treatments that are not available to the public.
You will get expert medical care at leading health care facilities during the clinical trial.
You will be helping others by contributing to medical research.

Here are some of the potential risks:

There may be side effects from medications or treatments.
The treatment may not work.
The clinical trial may require more of your time for trips to the study site, treatments, hospital stays, or complex dosage requirements than would be required for a standard treatment.
The new treatment may not be available to you right away once the clinical trial is finished.


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chrisca
Posts: 212
Joined: Wed Dec 07, 2011 10:35 pm
Location: Portland, Oregon

The Value of Botox-A for Management of Low Anterior Resection Syndrome

Postby chrisca » Sun Dec 27, 2015 6:38 pm

This one is closed, but worth watching:

The Value of Botox-A for Management of Low Anterior Resection Syndrome
https://www.clinicaltrials.gov/ct2/show/NCT01589471

Looks like they are trying to create a rectosigmoid junction to block the nerve signals from the colon from reaching the neorectum and provide better functioning.
Male, false negative colonoscopy age 48
DX: 12/2010 rectal cancer age 51
Stage T3N0M0 2 cm from anal verge
neoadjuvant rad/chemo Xeloda
Rectal resection (open surgery) straight anastomosis
Xeloda round 2
ileostomy reversal 11/2011
Successful adhesion X-lap 8/2013
Ongoing LAR syndrome but NED 5 years

JFrog
Posts: 21
Joined: Wed Aug 26, 2015 7:55 am

CPI-444 with PD-L1, good preclinical data

Postby JFrog » Thu Jan 14, 2016 9:11 am

This is a trial starting soon with an A2A receptor inhibitor that may help PD-L1 work for MSS mCRC. No trial locations listed yet and it will be randomized but it has excellent pre-clinical data/models;

https://www.clinicaltrials.gov/ct2/show ... 016&rank=9

NCT trial number: NCT02655822
DW dx 5/2012 Stage II @ age 45; MSS;
Emergency colostomy
5FU radiation
Resection 10/2012 and FOLFOX
Recurrence local and liver 5/2013
FOLFIRI 8 rds, Xeloda and repeat radiation
Liver res. 3/2014, repeat pelvic res. 7/2014
Liver(2) and lung recurrence(1) 9/2014, Iri w/ pan until progression then FOLFOX w/ Avastin until progression
MDA Targeted Therapy Clinical Trial 8/2015, Progressed10/15-off trial
Iri and pan. 11/2015
SBO 2/16 with successful resection 3/9/16
Clinical Trial AZD1775, 4/21/16

JFrog
Posts: 21
Joined: Wed Aug 26, 2015 7:55 am

CPI-444 with PD-L1 now recruiting

Postby JFrog » Mon Feb 01, 2016 11:48 am

The CPI-444 w/ PD-L1 now recruiting in San Antonio. DK37 posted lots of information on this trial
DW dx 5/2012 Stage II @ age 45; MSS;
Emergency colostomy
5FU radiation
Resection 10/2012 and FOLFOX
Recurrence local and liver 5/2013
FOLFIRI 8 rds, Xeloda and repeat radiation
Liver res. 3/2014, repeat pelvic res. 7/2014
Liver(2) and lung recurrence(1) 9/2014, Iri w/ pan until progression then FOLFOX w/ Avastin until progression
MDA Targeted Therapy Clinical Trial 8/2015, Progressed10/15-off trial
Iri and pan. 11/2015
SBO 2/16 with successful resection 3/9/16
Clinical Trial AZD1775, 4/21/16

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

ECOG Scale of Performance Status

Postby Nik Colon » Wed Feb 03, 2016 8:58 am

To conduct clinical trials for the treatment of cancer in a consistent manner across many participating hospitals, cancer centers, and clinics requires the use of standard criteria for measuring how the disease impacts a patient’s daily living abilities (known to physicians and researchers as a patient’s performance status). The ECOG Scale of Performance Status is one such measurement. It describes a patient’s level of functioning in terms of their ability to care for themself, daily activity, and physical ability (walking, working, etc.).

http://ecog-acrin.org/resources/ecog-performance-status
Last edited by Nik Colon on Thu Feb 04, 2016 6:52 pm, edited 8 times in total.
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Find a Cancer Mutation

Postby Nik Colon » Thu Feb 04, 2016 6:48 pm

Find a Cancer Mutation
http://www.mycancergenome.org/
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

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O Stoma Mia
Posts: 802
Joined: Sat Jun 22, 2013 6:29 am

Links to NCCN Guidelines for Colon and Rectal Cancer

Postby O Stoma Mia » Fri Feb 05, 2016 4:58 am

In the U.S. there is an organization with a website for physicians and patients with very detailed decision trees (flowcharts) to help physicians decide which treatment to start off with. These decision trees require data from the various pathology reports and scan reports. The organization is NCCN (National Comprehensive Cancer Network), and it has separate web pages and separate decision trees for Colon Cancer treatment and Rectal Cancer treatment.

These two types of cancer are treated differently, for the most part because Rectal Cancer often has a chemo/radiation component which Colon Cancer does not usually have. In that sense, Rectal Cancer treatment can be considered more aggressive because it is pursued with both chemo and radiation.

Again, it is important to note that the two domains are different, and the documents consulted by physicians in determining treatment are different. (Of course, they are not totally different. There are cases where certain branches of the decision tree are exactly the same for Colon and for Rectal, but Rectal Cancer has some branches in the decision tree that Colon Cancer does not have.)

When you are consulting with your doctor, it is important to find out which document and which decision tree he/she is following, since the two documents are different and are of different lengths.


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DK37
Posts: 502
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: DK37 Science Posts List

Postby DK37 » Sat Feb 06, 2016 11:04 am

CRguy wrote:Our own member DK37 will update his list of Science Posts HERE
to keep his research investigations current.


Just to make clear - my Science posts links mentioned in the thread above (and now with their own sticky!) contain both basic science as well as new CRC clinical trials as I find them. So hit the link for clinical trials too!

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://colorectalmsstrials.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

turtle
Posts: 24
Joined: Wed Apr 15, 2015 5:02 pm
Location: Encinitas, CA
Contact:

Stage III CC patients: Duke CEA vaccine clinical trial

Postby turtle » Sun Sep 25, 2016 7:59 pm

Immunotherapy with CEA(6D) VRP Vaccine (AVX701) clinical trial at Duke for patients with Stage III Colorectal Cancer
Link: https://clinicaltrials.gov/ct2/show/NCT01890213?term=CEA%286D%29+VRP+Vaccine+%28AVX701%29&rank=2
A year ago, Duke told me that the clinical trial requires that a patient visit Duke in North Carolina many times, all seasons of the year (you cannot have your non-Duke oncologist do the testing and evaluation). As part of the study, at least one CT scan is done on you.

Instead of calling 919-668-1861 like the clinicaltrials.gov page indicates, you might get information faster by trying to schedule an appointment with Duke's gastrointestinal oncology center. You can be seen by Dr. Michael Morse or one of his colleagues.

ClinicalTrials.gov Identifier:
NCT01890213
Feb. 2015 at age 39: Dx stage IIIb cecal cancer extending into appendix
March 2015 at age 40: Began FOLFOX, discontinuing early after 10 cycles due to suicidal ideation and difficulty moving
Oct. 2016 at age 41: Dx stage IV with 3 metastases to lungs (one 3.7 cm x 2.2 cm) and 1 to liver
KRAS-mutation positive

User avatar
Maia
Posts: 2396
Joined: Fri Aug 24, 2012 8:00 am

NCT02888743 Durva (anti PD-L1) + Treme (anti-CTLA-4) + radiation

Postby Maia » Sat Nov 12, 2016 4:38 pm

NCT02888743
Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancer
https://clinicaltrials.gov/show/NCT02888743

Not yet recruiting. At Dana-Farber - Harvard Cancer Center. Boston, Massachusetts.

All 3 arms receive the 2 immuno drugs: A: two drugs without radiation; B: two drugs with radiation at a low dose; C: B: two drugs with radiation at a higher dose.
Lesion to be radiated has to be in liver.
Only for MSS

(Patients on the CRC arm need to have: "Microbiology Susceptibility Subcategory (MSS) tumor as documented by either:
Immunohistochemistry (IHC) testing that does not suggest loss of MLH-1, MSH-2, PMS2 or MSH6
Polymerase chain reaction (PCR) testing that does not suggest microsatellite instability (MSI))

durvalumab (MEDI4736): anti PD-L1, similar to atezolizumab.
tremelimumab: anti-CTLA-4, similar to ipilimumab.
More about the combination here: (May 2014) viewtopic.php?f=1&t=46727 and (Nov 2015) viewtopic.php?f=1&t=52938


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