Avastin and blood thinners , does anyone here do both? How bad is this idea?

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KElizabeth
Posts: 400
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Avastin and blood thinners , does anyone here do both? How bad is this idea?

Postby KElizabeth » Mon Dec 07, 2015 7:44 pm

To explain here's some background :
I suffered a TIA during my first treatment of Folfuri, and since, my doctors have been looking to find out why a normal healthy thirty- something would suffer a precursor to a stroke while just sitting around on the 5Fu pump. I was ready to blame the chemo, or blame the cancer and move on, but the doctor kept pressing.

Now after many tests, we have discovered that I have a genetic mutation that increases clotting and triples my chances for venous thrombosis and I am ine of the 25% of the population to have a congenital shunt in my heart that could allow a clot to go to my brain. That paired with the increased clotting caused by just having cancer is enough to warrant blood thinners, but I'm on Avastin, and already bleeding from the nose and gums daily.

Does anyone do both? My doctor said blood thinners and avastin were not necessarily contraindicated. ...
Why does this worry me more than a stroke?
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

stevieb
Posts: 410
Joined: Sat Feb 09, 2013 12:26 am

Re: Avastin and blood thinners , does anyone here do both? How bad is this idea?

Postby stevieb » Tue Dec 08, 2015 2:19 pm

I have been on Avastin and daily Lovenox shots since May when I had two small clots in my right lung. My onc. said that I will be on them for the rest of my life because he has been burned too many times when people got off of the blood thinners. I have had no side effects as of yet, BP is perfect still. Hope this helps!
Dx age 33
12/19/12 Stage IV liver/lung
1/14-2/28/13 Folfox
3/27/13 rectal/lung rst; temp ileo
7/11/13 liver res/ileo rev
9/30/13 - Folfox
11/13,2/21 NED
3/14 lung recur;6/16-VATS
7/14 5 bi lung mets
10&11/15 laser lung surg
2015 Colondar Model
12/15 5 lung met-folfiri
5/15 NED
11/15 2 lung mets; cryoablation
1/4/17 2 lung mets; cryoablation
NED as of 1/23/17

KElizabeth
Posts: 400
Joined: Sat Oct 31, 2015 12:41 pm
Facebook Username: KElizabeth
Location: Omaha

Re: Avastin and blood thinners , does anyone here do both? How bad is this idea?

Postby KElizabeth » Tue Dec 08, 2015 3:39 pm

It does help. Thanks. I am just super anxious over this and it helps to know there are others doing both without poor results.
Female age 39- ,2 teens.
Colon Cancer - DX March 2013
Age 34 at DX - Stage III B
Resection surgery -May 2013
FOLFOX - June, 2013 to Sept, 2013
5FU plus leukavorin Sept, 2013 to Dec, 2013
METs liver and lungs discovered Sept, 2015
KRAS - MSS
FOLFIRI plus Avastin - Sept, 2015 - July 2017
Durvalumab and Cediranib Sept 2017 Dec 17
FOLFOX with desensitization protocol - current

Ceebo
Posts: 132
Joined: Sat Feb 14, 2015 9:15 am
Location: Southwest Michigan

Re: Avastin and blood thinners , does anyone here do both? How bad is this idea?

Postby Ceebo » Tue Dec 08, 2015 6:46 pm

My husband was on both Avastin and Lovenox (due to a DVT) for approximately 14 months and didn't have any problems. He had to stop the Avastin when the FOLFIRI was discontinued due to disease progression. ---Cindie
DH 64 Stage 4 on 4/14 ; cecal tumor; 5+ nodes ; mets to liver; colon resection
5/14 FOLFOX
9/14 - Liver surgery aborted; peri mets
10/14 CT mult.1-2 mm lung mets; FOLFIRI & Avastin
1/15 CT -liver & lung mets shrinking
3/15 PET - ? New met. site colon; CEA rising
7/15 Chemo has failed; looking for clinical trial
9/29/15 started TAS-102 trial
KRAS mutant; MSS

User avatar
Mastan
Posts: 433
Joined: Sat Feb 19, 2011 11:12 am
Location: Albuquerque, NM

Re: Avastin and blood thinners , does anyone here do both? How bad is this idea?

Postby Mastan » Wed Dec 09, 2015 10:57 am

Been doing both since February 2015. No problems yet.
Dx 6/2010 rectal CA

ripley86
Posts: 89
Joined: Tue Jul 30, 2013 9:22 pm

Re: Avastin and blood thinners , does anyone here do both? How bad is this idea?

Postby ripley86 » Wed Dec 09, 2015 9:07 pm

I was doing Avastin and Lovenox since February this year
Didn't have any issues but had to watch for cuts due to my neuropathy to make sure I could stop the bleeding.
Female, 62 yo
DX Sept 2012
Xeloda with rad 28 treat
Surgery, resection 4/13
6/33 lymph nodes +
Shadow on liver found in ER 6/13
Folfox with Avastin 6/13
2 nodules in left lung
(4mm and 2mm)
Nodule rt lung 3mm to 8 mm
Folfiri started 9/14
ER due to clot on lung 2/15
Start Lovenox
Folfiri stopped 9/15
Started trial 12/15
Trial end 2/16
Started trial Stivarga 2/16


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