Merck (anti-PD-1) + Amgen (anti-CSF1R) CRC Immunotherapy Trial Announcement

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Merck (anti-PD-1) + Amgen (anti-CSF1R) CRC Immunotherapy Trial Announcement

Postby DK37 » Sun Dec 06, 2015 9:10 am

A new CRC immunotherapy PD-1 combo clinical trial has just been announced by Merck (anti-PD-1) and Amgen (anti-CSF1R). IT IS HIDDEN BENEATH THE NHL STORY HEADLINE at the link but it is in there! They haven't announced yet if they will allow MSS patients, but based upon the mechanism of action (to make a "cold tumor hot" and the fact they are going after another "cold tumor type" (pancreatic) I think there is a reasonable chance this will be open to MSS patients.

It is not in with inclusion/location details yet but I'll update once it is. ... ymphoma/?/

6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder:
2016 Colondar 2.0 Model
DK37 Science Posts List

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Joined: Sat Aug 15, 2015 7:47 am

Re: Merck (anti-PD-1) + Amgen (anti-CSF1R) CRC Immunotherapy Trial Announcement

Postby jortego128 » Sun Dec 06, 2015 9:22 pm

Thanks DK.
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016

Posts: 612
Joined: Wed May 14, 2014 1:32 am

Re: Merck (anti-PD-1) + Amgen (anti-CSF1R) CRC Immunotherapy Trial Announcement

Postby Stanfordmom » Mon Dec 07, 2015 3:54 am

This is great news! Thank you so much, DK!
DX 4/2/2014 at 44, stage 4, mets liver and ovaries
Mom to 2 boys
Three surgeries, HAI pump and lots of chemo

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