CRC/Immunotherapy Expert Roundtable Meeting This Week

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DK37
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Location: San Diego

CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby DK37 » Mon Nov 30, 2015 7:12 am

I've been involved with the lead-up to this Dec. 2 meeting via working with both Fight CRC and CRI. I have hopes of the productive discussion that will occur when so many CRC & immunotherapy experts from a wide range of research institutions and companies are all sitting together, this kind of large joint round table meeting has never happened before.

-DK
Pasted from the link at the bottom:
On December 2, the two organizations will bring together over 20 global experts in immunotherapy, GI oncology and basic science in New York City for a discussion on the current state of science and the future direction of immunotherapy research for colorectal cancer therapies. A white paper, Evaluating the role of immunotherapy: Addressing the potential for breakthrough treatments for colorectal cancer, will be released in April 2016 following the American Association of Cancer Research annual meeting. -

Rallying Leading Experts
A multidisciplinary group will be led by Dung T. Le, M.D., from Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, and Al B. Benson III, M.D., FACP, from the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. It will be the first time the following leading experts in colorectal cancer immunotherapy research have all convened around the same table:

Dr. Al Benson, Northwestern University
Dr. Emily Chan, Vanderbilt University
Dr. Dustin Deming, University of Wisconsin
Dr. Luis Diaz, Johns Hopkins
Dr. Wolf Fridman, INSERM
Dr. Franck Housseau, Johns Hopkins
Dr. S. Peter Kang, Merck
Dr. Smitha Krishnamurth, Case Western University
Dr. Dung T Le, Johns Hopkins
Dr. Wells Messersmith, University of Colorado
Dr. Cynthia L. Sears, Johns Hopkins
Dr. Neil Segal, Memorial Sloan Kettering Cancer Center
Dr. Arvin Yang, Bristol-Myers Squibb
Dr. Rebecca Moss, Bristol-Myers Squibb
Dr. Edward Cha, Genentech
Dr. Tom Dubensky, Aduro Biotech
Dr. Dirk Brockstedt, Aduro Biotech

http://www.cancerresearch.org/news/2015 ... unotherapy
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

jortego128
Posts: 288
Joined: Sat Aug 15, 2015 7:47 am

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby jortego128 » Mon Nov 30, 2015 10:01 am

Hopefully some new ideas and solid research direction will come out of this.
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby DK37 » Mon Nov 30, 2015 6:32 pm

jortego128 wrote:Hopefully some new ideas and solid research direction will come out of this.


People involved in the meeting are taking it very seriously, so I am hopeful that good will come out of it. All eyes are on some of the other major cancers with recent immunotherapy success. We (and all the CRC advocates & CRC scientists) want MSS CRC's turn now too!

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

mariane
Posts: 676
Joined: Sun Sep 13, 2015 6:16 pm

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby mariane » Mon Nov 30, 2015 7:20 pm

Fingers crossed!
mom of now 10 years old twins, dx @ 40 in 6/2015 with upper rectal cancer, 10+ liver mets, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!

JDinNC
Posts: 771
Joined: Fri Jul 05, 2013 9:49 pm
Location: Murphy, N.C.

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby JDinNC » Mon Nov 30, 2015 7:56 pm

I hope there's a major breakthrough with this meeting..we are all looking for something that's promising .
61 y/o female @ DX...........
T3N0M1
6/13 DX- stage 4
Sigmoid colon cancer.
One met to lung
7/13 colon resection
8/13 lung resection
7/17 four years....NED
8/18 five years....NED
MELANOMA
63 y/o @ DX
6/15 stage 2a
7/15 surgery on arm
7/15 NED
4/16 recurrance
5/16 remove metastasis from back
5/16. Started immunotherapy
8/16 discontinue treatment
7/18...PET scan...NED

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby ieowi » Tue Dec 01, 2015 3:39 am

Hope things turn out good for mss patients, as for us it's getting a bit late, we have to make a decision. We r seeing memorial Sloan next Friday, hope things work out well for my father.
Last edited by ieowi on Tue Dec 01, 2015 12:52 pm, edited 1 time in total.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

Ceebo
Posts: 132
Joined: Sat Feb 14, 2015 9:15 am
Location: Southwest Michigan

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby Ceebo » Tue Dec 01, 2015 5:39 am

I will be praying that some new research ideas for those that are CRC MSS come out of this exciting meeting! My DH is running out of viable treatment options! He continues to be in the TAS-102 trial, but we don't have another good option after thal! Thank you for keeping us updated about this landmark event!! Miracles do happen and this event, with all of these great scientific minds together for the first time, is a testament of that belief!!
DH 64 Stage 4 on 4/14 ; cecal tumor; 5+ nodes ; mets to liver; colon resection
5/14 FOLFOX
9/14 - Liver surgery aborted; peri mets
10/14 CT mult.1-2 mm lung mets; FOLFIRI & Avastin
1/15 CT -liver & lung mets shrinking
3/15 PET - ? New met. site colon; CEA rising
7/15 Chemo has failed; looking for clinical trial
9/29/15 started TAS-102 trial
KRAS mutant; MSS

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby DK37 » Wed Dec 02, 2015 4:23 pm

I haven't heard specifics yet (unfortunately I was unable to attend in person) but in terms of generalities, I believe that MSS CRC was intended to be a MAJOR focus of discussion.

Everyone knows us MSS folks need help - cross-pollination of unpublished data discussion and next steps brainstorming at a group of experts-level meeting such as today's can only speed things up, it was really important that this meeting occurred... They know we are all trying to hold on, waiting for the immunotherapy wave to finally arrive to our corner of the cancer world...

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

Steph20021
Posts: 553
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby Steph20021 » Fri Dec 04, 2015 12:15 am

Looking forward to your update on this DK.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, NED
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
01/17- pulmonary embolism
02/17- 1 wk radiation to abdo wall
08/16- on folfiri
01/18-folfox
11/18- Beacon trial-encorafenib & cetuximab

NateA
Posts: 115
Joined: Sun Aug 02, 2015 7:41 pm
Facebook Username: Nathan Drew Allen

Re: CRC/Immunotherapy Expert Roundtable Meeting This Week

Postby NateA » Fri Dec 04, 2015 5:25 am

Hold on is right! Holding strong, come on science!
7/15 dx CC stage 4 with lots of liver mets CEA 208
KRAS Mutant G12V, MSS.
9/23 from folfoxiri to folfox and Xeloda. CEA 25
11/11/15 all liver markers in the zone, CEA 4.0, moving to Avastin/xeloda for now..tumors shrinking
01/13/16 Avastin/xeloda CEA 3.5
03/11/16 clean PET CEA 4.4


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