The Currently Incurable Scientist: REPROGRAMMING A TUMOR FOR DEATH (RRx-001)

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

The Currently Incurable Scientist: REPROGRAMMING A TUMOR FOR DEATH (RRx-001)

Postby DK37 » Tue Nov 17, 2015 9:12 pm

RRx-001 is an old topic here on Colon Talk (you guys always hear things faster than the broader world ;) but I wrote two columns about RRx-001 today, in a more cohesive and organized fashion than before.

The "Currently Incurable Scientist" Column discusses RRx-001's science & preliminary clinical data in succinct, layman's terms:
http://fightcolorectalcancer.org/resear ... for-death/

On my personal blog "Adventures in Living Terminally Optimistic" I wrote a companion blog post where I focus on the INCREDIBLE “story behind the story” – where an EARLY ON-SET CRC PATIENT was instrumental in DISCOVERING the drug! “RRX-001 AND THE IMPACT OF ONE CRC PATIENT-CHEMIST” I hope you find this amazing story interesting, fingers crossed it will have a good ending for all of us in the CRC world!
http://adventuresinlivingterminallyopti ... t-chemist/

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: The Currently Incurable Scientist: REPROGRAMMING A TUMOR FOR DEATH (RRx-001)

Postby ieowi » Tue Nov 17, 2015 10:05 pm

thanks DK37 ,,,,,,going through, with Siri you can laydown and listen :)
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

mariane
Posts: 630
Joined: Sun Sep 13, 2015 6:16 pm

Re: The Currently Incurable Scientist: REPROGRAMMING A TUMOR FOR DEATH (RRx-001)

Postby mariane » Tue Nov 17, 2015 10:37 pm

Very interesting! Fingers crossed!
Looks really promising:

http://annonc.oxfordjournals.org/conten ... 4.abstract

Have you seen this, Tom? Worked in all patients from the small group who received RRx-001. The results were independent from the KRAS status.
mom of now 9 years old twins, dx @ 40 in 6/2015 with upper rectal cancer, 10+ liver mets, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: The Currently Incurable Scientist: REPROGRAMMING A TUMOR FOR DEATH (RRx-001)

Postby DK37 » Tue Nov 17, 2015 11:48 pm

mariane wrote:Very interesting! Fingers crossed!
Looks really promising:

http://annonc.oxfordjournals.org/conten ... 4.abstract

Have you seen this, Tom? Worked in all patients from the small group who received RRx-001. The results were independent from the KRAS status.


Yes I have seen! I linked to it in my personal blog but not in the Fight CRC column. I made a personal rule to only use peer-reviewed data in the Fight CRC column (since more rigorous) but I am more flexible on my personal blog if I feel the source appears trustworthy :)

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

mariane
Posts: 630
Joined: Sun Sep 13, 2015 6:16 pm

Re: The Currently Incurable Scientist: REPROGRAMMING A TUMOR FOR DEATH (RRx-001)

Postby mariane » Thu Nov 19, 2015 8:58 pm

Thank you Tom for all you are doing! Your posts give hope and change lives of many!
mom of now 9 years old twins, dx @ 40 in 6/2015 with upper rectal cancer, 10+ liver mets, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!


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