Two more PD-(L)1 Combo Trials Hoped to Make MSS-CRC Tumors "Hot" Towards the Immune System (IDO1 & CD73)

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jortego128
Posts: 288
Joined: Sat Aug 15, 2015 7:47 am

Re: Two more PD-(L)1 Combo Trials Hoped to Make MSS-CRC Tumors "Hot" Towards the Immune System (IDO1 & CD73)

Postby jortego128 » Sun Nov 15, 2015 8:36 pm

I know you are short on time, and sadly I fear we are also. Etubics has what looks to be a very promising vaccine trial for all CRC patients starting sometime in the first half of 2016. In my opinion it looks like one of if not THE most promising up-and coming CRC trials, but unfortunately they dont even have a solid date yet, at least published on the internet. Perhaps someone at Etubics would have more up-to-date info than their latest press release.
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: Two more PD-(L)1 Combo Trials Hoped to Make MSS-CRC Tumors "Hot" Towards the Immune System (IDO1 & CD73)

Postby ieowi » Sun Nov 15, 2015 8:42 pm

jortego128 wrote:I know you are short on time, and sadly I fear we are also. Etubics has what looks to be a very promising vaccine trial for all CRC patients starting sometime in the first half of 2016. In my opinion it looks like one of if not THE most promising up-and coming CRC trials, but unfortunately they dont even have a solid date yet, at least published on the internet. Perhaps someone at Etubics would have more up-to-date info than their latest press release.


I think someone talked about this before, I will keep an eye on it thank you for sharing I hope you find something for your Mom.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

Lee
Posts: 6207
Joined: Sun Apr 16, 2006 4:09 pm

Re: Two more PD-(L)1 Combo Trials Hoped to Make MSS-CRC Tumors "Hot" Towards the Immune System (IDO1 & CD73)

Postby Lee » Sun Nov 15, 2015 8:47 pm

janderson wrote:Thanks for the update DK. THis is encouraging. I really appreciate the time you spend posting and educating us.

Thanks again
Jeff


It's people like you (and others) who make this site so WONDERFUL!! Thank you for all the work/research that you do.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 16 years and counting!

bitchslapped
Posts: 1538
Joined: Tue Sep 09, 2014 3:23 pm
Location: PNW/USA

Re: Two more PD-(L)1 Combo Trials Hoped to Make MSS-CRC Tumors "Hot" Towards the Immune System (IDO1 & CD73)

Postby bitchslapped » Mon Nov 30, 2015 1:14 pm

Are these on your "List" DK? Maybe I'm just missing it.

BS
DSS,35YO,unresect mCRC DX 7/'14,lvr,LN,peri,rib
FOLFOX+Avstn 4 Rnds d/c 10/'14
Stent 9/'14
FOLFIRI+Avstn 10/'14
Gone From My Sight 2/20/15
Me:garden variety polyps + precancerous polyp, diverticulitis
Carergver x2 DH,DM dbl occupancy,'03-'10
DH dx 47YO mCRC,'04-'07, lvr, billiary tree fried x HAI
DM dx CC 85YO,CC,CHF,stroke,dementia,aphasia

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: Two more PD-(L)1 Combo Trials Hoped to Make MSS-CRC Tumors "Hot" Towards the Immune System (IDO1 & CD73)

Postby DK37 » Mon Nov 30, 2015 6:39 pm

bitchslapped wrote:Are these on your "List" DK? Maybe I'm just missing it.

BS


Yes - they are listed in my list of science posts in my signature line. If you are asking about my personal trial "list" - yes, like all PD-1 combo trials they are on my personal "watch list" waiting for data to emerge, for now it is chemo for me (hopefully it keeps working).......

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List


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