jortego128 wrote:**Edit: These results are not from the Opdivo combo, but from the Keytruda combo-- that may explain the absence of CRC patients.
Incite posted some prelim results of the IDO1 (Epacadostat)+ Opdivo trial being held in Birmingham, AL. This release shows results of several solid tumor cancers, but CRC was not included in the release, despite the trial stating it was accepting CRC patients. I wonder if CRC wasnt shown due to lack of patients in the trial or lack of response...
ieowi, if you are having trouble finding a trial and need one now, perhaps you could call and inquire if there are indeed any CRC patients and if any MSI-low or MSS patients have responded.http://investor.incyte.com/phoenix.zhtm ... ID=2105804http://www.immunotherapyofcancer.org/co ... -S2-O7.pdf
thank you, I have already seen these results the only issue here is this trial doesn't show if IDO1 did anything for the patients as they combine both of them, so if you combine water with keyrtuda you may end up with these results too.
DK37 may have more to say about this.
furthermore I have contacted San Antonio ( one of the locations doing the combination Keyrtuda+IDO1 ) and this is what they said """" IN THEORY IT IS POSSIBLE TO WORK ON MSS, MSI-LOW BUTTTTTTTTTTTT IN MY OPINION NOT LIKELY"""""
that's was there respond. so we left this behind us I will take there word for it we can't risk anything considering Dad condition. They said though you are welcomed to try but in feb. as they already have one patient and two in the waiting list.
the CD73 will start soon I called duke university NC, it would be escalation dose for a couple of month for CD73 then they would combine them both, I don't think we have that much of time.
so I am waiting to see if MSKCC have something else to offer beside what they first suggested, which wasn't very realistic. and tomorrow we will see MDA to see what they have.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!