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DK37 Science Posts List

Posted: Tue Oct 20, 2015 10:26 pm
by DK37
Following a suggestion/request from Nik - here is a list of links to the various science post threads I've started since I started posting on Colon Talk in last 2014.

I'll try (hard) to remember to update it with new links when I make new posts.

Up to you guys if you think it is useful or not... THANK YOU NIK for compiling this starter list for me! It's in chronological order.


Nov 25, 2014
New CRC Immunotherapy Trial Announced: anti-PD1 + anti-CSF1R

Jan 09, 2015
Forbes - Immuno-oncology Story

Feb 20, 2015
New CRC Immunotherapy Paper: PD-L1 + ITK Inhibitors

Feb 27, 2015
Advance Screening - Emperor of All Maladies (Ken Burns)

Mar 16, 2015
New Pilot Clinical Trial Results for BRAF-mut Stage IV CRC

Mar 18, 2015
RRx-001 Prelim. Phase 2 Data - Resensitizing Tumors to chemo

Mar 23, 2015
Updated RRx-001 Preliminary Phase 2 Trial Data

Apr 19, 2015
Johns Hopkins Immunotherapy Paper: 100% CRC cure rate in a poorly immunogenic CRC Mouse Model

Apr 25, 2015
New Arizona Trial: Nivolumab (PD-1 Immunotherapy) + XELIRI/Irinotecan

Apr 27, 2015
Update on MGD007 Trial – New Sites Open!

May 17, 2015
KRAS-wt: Clinical Trial Results for Sym004 (after cetuximab resistance)

May 29, 2015
Potential to be Biggest CRC Drug Breakthrough in Years (ASCO Results - PD1 for MMR-deficient CRC)

Jun 27, 2015
My Blood Biopsy Story (From Voxx66's News from Dr appt post)

Jul 07, 2015
Preliminary Clinical Trial Data for "Xilonix" - Currently in Phase 3 Trials for mCRC

Jul 14, 2015
New Monthly DK Column: The Currently Incurable Scientist

Jul 24, 2015
The Currently Incurable Scientist: Turning a Cold CRC Tumor Hot

Aug 08, 2015
Anti-4-1BB (CD137) Immunotherapy - e.g. Urelumab CRC Trial

Aug 13, 2015
The Currently Incurable Scientist: The Future of anti-EGFR Therapy?

Aug 18, 2015
Pushing for Lung RFA & the Power of Hope

Aug 20, 2015
RRx-001 Phase 1 Clinical Trial Results Published in Lancet Oncology

Aug 21, 2015
Anti-Immunosuppression PD-1 Co-therapies for CRC (Reply to Jortego128’s Bavituximab for Rectal Adenocarcinoma... post)

Aug 31, 2015
New PD-1 Inhibitor Combo Studies for CRC (All or MSS Specific)

Sep 08, 2015
Immunotherapy Suggestion: Add MSI/MSS Status to Your Signature Line (Explained)

Sep 15, 2015
Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Sep 22, 2015
TAS-102 FDA Approved!

Oct 01, 2015
Neon Therapeutics - TIL ImmunoTherapy

Oct 11, 2015
Sneak Peek - Major MSI Education Project

Oct 13, 2015
The Currently Incurable Scientist:Releasing the PD-1 Brakes in MSI-High CRC Patients

Oct 14, 2015
The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1

Oct 17, 2015
FPA008 (anti-CSF1r) + PD-1 Inhibitor Deal Announced (Trial Already Started)

Oct 18, 2015
MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Nov 2, 2015
Two more PD-(L)1 Combo Trials Hoped to Make MSS-CRC Tumors "Hot" Towards the Immune System (IDO1 & CD73)

Nov 9, 2015
Impacts of Gut Bacteria (probiotics) on Immune Response to Tumors - anti-PD(L)1 Synergy but also taken alone.

Nov 17, 2015
The Currently Incurable Scientist: REPROGRAMMING A TUMOR FOR DEATH (RRx-001)

Nov 24, 2015
RRx-001 Phase 2 Trial: New East Coast Site

Dec 6, 2015
Merck (anti-PD-1) + Amgen (anti-CSF1R) CRC Immunotherapy Trial Announcement

Jan 12. 2016
BMS (major Opdivo & Yervoy immunotherapy company) announces their 2016 strategic plans, including MSS-CRC at the JP Morgan Healthcare company

Jan 15, 2016
New Immunotherapy Combo Trial Open to both MSI-high & MSS CRC (CPI-444; adenosine-A2A combo)

Jan 22, 2016
Potential new biomarker to identify Stage 2 CRC patients who would benefit from chemotherapy

Jan 25, 2016
New MSS CRC Phase 1 Trial: PF-06671008 (P-cadherin targeting)

Jan 28, 2016
BBI-608 Clinical Trial Update

Feb 4, 2016
Personalized Immunotherapy: Therapeutic Vaccines

Feb 6, 2016
New MSS-CRC Immunotherapy Trial: JNJ-61610588 (anti-VISTA)

Feb 10, 2016
MSS-CRC Immunotherapy Trial: AM0010

Feb 15, 2016
For KRAS-Mutant CRC: PD-1 Combination Trial with cobimetinib (MEK inhibitor)

Feb 26, 2016
DK's Personal Cancer Research Science Project

March 19, 2016
New MSS Trial: anti-CSF1R "AMG 820" + anti-PD1

March 19, 2016
MSS Trial: Anti-CD27 (Varlilumab) and Anti-PD-1 (Nivolumab)

April 4, 2016
Crowdfunding a New CRC Trial at UCSD (Pulse High Dosed erlotinib)

April 8, 2016
CCR2 Antag Clinical Immunotherapy Activity Against a "Cold" Tumor Type (Not CRC but Keep Reading!)

April 15, 2016
AACR-2016 Clinical Trial Poster Abstracts: IMMU-130, CFI-400945, AM0010



April 20, 2016
AACR-2016 Trial Data Release + 1st MSS-CRC Combo-Immunotherapy Trial Results Announcement for ASCO-2016

May 2, 2016
New MSS-CRC Immunotherapy Trial - PDL1/CTLA4/FOLFOX - Liver-only Mets

New MSS-CRC Immunotherapy Trial: TIL Trial at MD Anderson

May 3, 2016
New MSS-CRC Immunotherapy Trial: Erbitux+Keytruda

May 18, 2016
BIG (BIG!) MSS-CRC Immunotherapy News Out of ASCO! (MEKi + PDL1i)

May 20, 2016
French MSS-CRC Trial (PDL1 + anti-CSF1R)

May 24, 2016
MDA Personalized Therapeutic Vaccine Now Recruiting

May 31, 2016
New MSS-Elegible PDL1 Combo Trial (RO6895882, CEA-targetted IL2)

June 2, 2016
READ! PHASE 3 MSS-CRC Immunotherapy Trial Just Registered!! (Cobi + Atezo)

June 5, 2016
Today's ASCO-2016 Oral Presentation on MSS-CRC PDL1-MEK Immunotherapy Success

June 5, 2016
ASCO-2016: Updated PD1 vs PD1-CTLA4 Immunotherapy for MSI-high CRC

June 11, 2016
Global Randomized Phase 3 Clinical Trial for BRAF-mut CRC

June 15, 2016
Phase 2 Clinical Trial: BAX69 + either 5-FU or Panitumumab SoC

June 15, 2016
BRAF-Mutant Small Bowel Cancer (or other rare cancers)

June 15, 2016
New RRx-001 Non-Randomized Trial (Northern CA & NJ)

June 24, 2016
Interview with Clinical Trial Principal Investigator of MSS-CRC MEK-PDL1 Immunotherapy Breakthrough

August 3, 2016
MSS-CRC: New Oncolytic Virus + PD1 Inhibitor Trial

August 7, 2016
Combination of radiotherapy (radiation) with PD1 immunotherapy in MSS-CRC

August 19, 2016
New MSS-CRC PD1 Immunotherapy Trial in MINNESOTA

August 19, 2016
Cleveland Clinic: New CRC Targeted Therapy Trial

September 2, 2016
Immunotherapy Trial: Patients WITH Brain Metastases

September 18,2016
New MSS-CRC Immunotherapy Trial: Arginase Inhibitor CB-1158

September 23, 2016
Big Trial Announcement: MSS-CRC/KRAS-Mut TCR Cellular Immunotherapy Trial from Kite Pharma

September 26, 2016
***My personal project***

September 27, 2016
MSS-CRC: PD1/NKTR-214 Combo Trial Announcement

September 29, 2016
Fasting and Chemo: My Take on It

October 1, 2016
Citizen Science: Reporting of FASTING and Chemo Results

October 16, 2016
***My Personal Trial***

November 4, 2016
Big New MSS-CRC Immmunotherapy Trial: anti-CD47

November 19, 2016
Peri Mets / MSS-CRC Immunotherapy Trial (Oncolytic Virus + anti-PDL1)

November 20, 2016
A Potential MSS-CRC Immunotherapy From an AIDS Drug Start: The CCR5 Receptor Antagonist Maraviroc

December 7, 2016
MSS-CRC Trial: Phase 2 Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal Cancer

December 7, 2016
MSS-CRC Immunotherapy Trial: CEA-CD3 Bifunctional + PDL1 Inhibitor

January 4, 2017

July 6, 2017
My personal choice for best ASCO-2017 MSS CRC Clinical Trial and Presentation

Re: DK37 Science Posts List

Posted: Sat Jan 30, 2016 10:27 pm
by DK37

Re: DK37 Science Posts List

Posted: Thu Oct 19, 2017 4:50 pm
by CRguy

Re: DK37 Science Posts List

Posted: Tue Nov 27, 2018 1:54 pm
by GrouseMan
OK since DK (Tom) has passed and we all miss him. And I see that few science posts have been made in a while - I thought I would post a link to something I read this morning concerning a Mushroom extract used in Taiwan that had been used to treat several conditions in folk medicine including bowel cancer. Being a former Drug Discovery chemist doing anticancer research, I have often had occasion to examine plant derived compounds as potential anti-cancer drugs. Typically we isolate the active ingredients and test them look for the one with the most activity and then modify it to make it a better drug candidate.

The paper I am linking to create a extract from the Antrodia cinnamomea mushroom that only grows on a particular type of tree in Asia. They found that a particular isolated fraction containing several natural product carboxylic acids seem to be quite active against many colon cancer cell lines we use in research - they tested about 6 of them and the extract was active against all of them to some degree or other. That is pretty good as some of these are resistant to some other chemotherapy agents. On very close examination using methods that are over even my head not being a molecular biologist they determined that this extract worked on the CHOP/TRB3/Akt/mTOR signaling pathway in colorectal cancer cells. They showed this to be the case in isolated tumor cells as well as in mouse xenographs and in a dose response manner. BTW this was all via direct exposure of the tumor cells to the extracts in a dish or via injection into the blood stream in the mouse.

Of course this is all very early and basic work. There have been many studies of these sorts of extracts from this mushroom showing activity against a couple of different cancers but until now no one knew what the mechanism of action was. So - it may one day provide another natural product derived anti-cancer drug now that they have some idea how the extract works and what the major components of the extract are.

Here is a link to the paper - Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells:

Its rather technical but I found it an interesting read.


Re: DK37 Science Posts List

Posted: Tue Nov 27, 2018 6:29 pm
by cartech78
Did i read the study right that it could work good with 5fu? Couldn’t make out if they were saying it was good with 5fu or diminished 5fu efficacy. Im on 2g of curcumin, 3g of micronized resveratrol, and low dose aspirin currently With my Folfox regimen. Interested in trying this if it plays well with Folfox.

Re: DK37 Science Posts List

Posted: Wed Nov 28, 2018 12:40 am
by GrouseMan
cartech78 wrote:Did i read the study right that it could work good with 5fu? Couldn’t make out if they were saying it was good with 5fu or diminished 5fu efficacy. Im on 2g of curcumin, 3g of micronized resveratrol, and low dose aspirin currently With my Folfox regimen. Interested in trying this if it plays well with Folfox.

It was used as a control to compare gene expression following treatment with 5-FU to that with treatment using the ACF2 extract. They were not used together in this paper. I suspect that they might be synergetic but that experiment would have to be done. Also note - even if you can find this extract used in this paper it would have to be prepared fresh, as I suspect it would degrade rather quickly being a mixture of very polar molecules. On going back and reading the actual Mouse experimental details it appears they give the extract orally once daily at 100, 200, and 400 mg/kg body weight. This surprises me as I would expect that the complex polar compounds found in the extract (a lot of complex carboxylic acids) would not survive oral administration and be sufficiently systemically bioavailable. If you weigh about 80 Kg you would have to take 32 grams of this per day at the highest dose. Something like 2.2 tablespoons of this extract per day. That's probably not going to go over very well in your GI track.

I think a lot more work needs to be done with these things, but it is still interesting now that they have a much better idea of their mechanism of action. Its still quite a mixture of chemicals and it might still be hard to determine which ones provide this profile or if its several acting on different parts of the signaling pathway at this point.



Re: DK37 Science Posts List

Posted: Wed Nov 28, 2018 1:25 am
by cartech78
Thanks for the reply! Yeah you’re right that is a shit ton of that stuff to take. Maybe if they can synthesize the stuff and mix it with pepper extract like curcumin it would be better absorbed. That science is miles and miles over my head. I wish we could get more money to go to research of these types of things. Im fairly certain there is something out there that can be taken with Standard Chemo to put it in overdrive. In the meantime I will keep popping supplements with just enough info to be dangerous :P

Re: DK37 Science Posts List

Posted: Thu Nov 29, 2018 6:50 pm
by CRguy
GrouseMan wrote:OK since DK (Tom) has passed and we all miss him...
And I see that few science posts have been made in a while - I thought I would post a link to something I read this morning ...


Thanks GrouseMan
you are a valued member of this family and any input here, especially science / tech based is much appreciated !

Yes ... we do all miss Tom, and since Maia has also been MIA lately :(
I admit we could use some more input in this topic.

Cheers and Best wishes

Re: DK37 Science Posts List

Posted: Thu Jan 24, 2019 12:00 pm
by GrouseMan
OK - I know plenty of you have an interest in MSI, MSS and TMB with regards to Immunotherapy agent usage. There have been a number of studies publish in the last year or so, but I have found the following ones to be quite interesting, and I am hopeful that before long more people will have their tumors profiled for TMB (Tumor Mutation Burden). The first paper is the following:

Unfortunately I don't have a subscription to this journal so I can't access the paper at this time directly. Perhaps if I make a trip to the university I can get a copy of the paper. However - The following link I feel does a very good job of reporting the results of the above paper very well. ... unotherapy

In these paper they point out different solid tumor types have different TMB cutoff levels where Immunotherapy drugs have a significant benefit. For Colon Cancer they indicate a TMB of about 52. But I suspect there are exceptions where lower than this immunotherapy is still useful. The following paper is also quite interesting. ... 018-0285-5

It is quite detailed. Note all these papers I presented so far concern overall TMB for multiple tumor types. Thing is most of the data so far has been for Melanoma and NSCLC where these immunotherapy drugs have been approved the longest and the vast majority of patients have come from. So its probably a bit biased towards the TMB numbers associated with these tumor types.

Here is a citation just concerned with Colon Cancer MSI, MSS and TMB

Again I am sorry I don't have access to the last one directly either, but hopefully can get to a major research library sometime soon to read it. These are all very recent research publications. (Jan 2019) Hope everyone considering use of one of the immunotherapy drugs has a look, and armed with this new data perhaps can talk their oncologist into doing appropriate testing and consider these new treatments.