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MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Posted: Sun Oct 18, 2015 10:21 pm
by DK37
Here is another experimental Phase 1 clinical trial that I find scientifically interesting - so I am keeping a close eye on - another second strategy to attempt to make MSS-CRC "cold" tumors "hot". This one is exclusively for MSS patients & exclusively at Johns Hopkins.

It uses two "epigenetic" drugs in combination with a PD-1 inhibitor. In CRC animal models the drugs remove immunosuppressive signals - so enhance the power of immunotherapies such as PD-1 inhibitors. At least in animal models...

There is no CRC human clinical trial data released yet.

https://clinicaltrials.gov/ct2/show/NCT ... 172&rank=1

Preclinical paper it is based on: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136565/

-DK

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Posted: Sun Oct 18, 2015 10:35 pm
by ieowi
do you think by simply calling they would tell us if they had any responders ? unlike MSK they don't charge, however in MSK I had very clear questions and they didn't mind to get back to me with answers.

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Posted: Sun Oct 18, 2015 11:00 pm
by DK37
ieowi wrote:do you think by simply calling they would tell us if they had any responders ? unlike MSK they don't charge, however in MSK I had very clear questions and they didn't mind to get back to me with answers.


A long shot but in life in general I always follow the adage it never hurts to ask!

-DK

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Posted: Sun Oct 18, 2015 11:02 pm
by ieowi
DK37 wrote:
ieowi wrote:do you think by simply calling they would tell us if they had any responders ? unlike MSK they don't charge, however in MSK I had very clear questions and they didn't mind to get back to me with answers.


A long shot but in life in general I always follow the adage it never hurts to ask!

-DK

:lol: :lol: :lol:

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Posted: Mon Oct 19, 2015 5:28 am
by Ceebo
Thanks once again for this information! Sounds like an interesting trial. So thankful that there are new trials becoming available specifically for people who are MSS. I was feeling like there weren't any other options for my DH and I was feeling a bit frustrated. This gives us some hope for the future.
--Cindie

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Posted: Sun Oct 25, 2015 5:33 pm
by ieowi
FYI, Msi-low arm of this trial is closed