MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

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DK37
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Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Postby DK37 » Sun Oct 18, 2015 10:21 pm

Here is another experimental Phase 1 clinical trial that I find scientifically interesting - so I am keeping a close eye on - another second strategy to attempt to make MSS-CRC "cold" tumors "hot". This one is exclusively for MSS patients & exclusively at Johns Hopkins.

It uses two "epigenetic" drugs in combination with a PD-1 inhibitor. In CRC animal models the drugs remove immunosuppressive signals - so enhance the power of immunotherapies such as PD-1 inhibitors. At least in animal models...

There is no CRC human clinical trial data released yet.

https://clinicaltrials.gov/ct2/show/NCT ... 172&rank=1

Preclinical paper it is based on: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136565/

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Postby ieowi » Sun Oct 18, 2015 10:35 pm

do you think by simply calling they would tell us if they had any responders ? unlike MSK they don't charge, however in MSK I had very clear questions and they didn't mind to get back to me with answers.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Postby DK37 » Sun Oct 18, 2015 11:00 pm

ieowi wrote:do you think by simply calling they would tell us if they had any responders ? unlike MSK they don't charge, however in MSK I had very clear questions and they didn't mind to get back to me with answers.


A long shot but in life in general I always follow the adage it never hurts to ask!

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Postby ieowi » Sun Oct 18, 2015 11:02 pm

DK37 wrote:
ieowi wrote:do you think by simply calling they would tell us if they had any responders ? unlike MSK they don't charge, however in MSK I had very clear questions and they didn't mind to get back to me with answers.


A long shot but in life in general I always follow the adage it never hurts to ask!

-DK

:lol: :lol: :lol:
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

Ceebo
Posts: 132
Joined: Sat Feb 14, 2015 9:15 am
Location: Southwest Michigan

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Postby Ceebo » Mon Oct 19, 2015 5:28 am

Thanks once again for this information! Sounds like an interesting trial. So thankful that there are new trials becoming available specifically for people who are MSS. I was feeling like there weren't any other options for my DH and I was feeling a bit frustrated. This gives us some hope for the future.
--Cindie
DH 64 Stage 4 on 4/14 ; cecal tumor; 5+ nodes ; mets to liver; colon resection
5/14 FOLFOX
9/14 - Liver surgery aborted; peri mets
10/14 CT mult.1-2 mm lung mets; FOLFIRI & Avastin
1/15 CT -liver & lung mets shrinking
3/15 PET - ? New met. site colon; CEA rising
7/15 Chemo has failed; looking for clinical trial
9/29/15 started TAS-102 trial
KRAS mutant; MSS

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: MSS-CRC Immunotherapy Phase 1 Trial at Johns Hopkins (PD-1 + Epigenetic Drugs)

Postby ieowi » Sun Oct 25, 2015 5:33 pm

FYI, Msi-low arm of this trial is closed
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!


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