FPA008 (anti-CSF1r) + PD-1 Inhibitor Deal Announced (Trial Already Started)

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DK37
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Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

FPA008 (anti-CSF1r) + PD-1 Inhibitor Deal Announced (Trial Already Started)

Postby DK37 » Sat Oct 17, 2015 8:48 am

This co-development deal announced between BMS (maker of Opdivo (nivolumab)) and Five Prime Therapeutics is a PD-1 combo trial I am watching closely & crossing fingers for MSS CRC. It combines a PD-1 inhibitor with a drug called FPA008 which blocks something called CSF1R.

http://www.businesswire.com/news/home/2 ... h9lf75Aw20

Scientists hope that blocking CSF1R would remove immunosupression from the "tumor microenvironment" - and make "cold tumors" (e.g. MSS-CRC tumors are "cold") more "hot" i.e. able to be attacked by the immune system. This is a subject I wrote about in a general way here: http://fightcolorectalcancer.org/resear ... ot-part-1/

Here is the link to the Phase 1 trial. As far as I know it is open to both MSI and MSS CRC patients. It just started in TX - they are planning a big trial so I am sure multiple additional sites will be opening soon.
https://clinicaltrials.gov/ct2/show/NCT ... 008&rank=1

This is a Phase 1 trial so no clinical data that it works yet - but from a purely scientific point of view, I think worthy of keeping a very close eye on!

-DK
Last edited by DK37 on Sat Oct 17, 2015 9:28 am, edited 1 time in total.
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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Ceebo
Posts: 132
Joined: Sat Feb 14, 2015 9:15 am
Location: Southwest Michigan

Re: FPA008 (anti-CSF1r) + PD-1 Inhibitor Deal Announced (Trial Already Started)

Postby Ceebo » Sat Oct 17, 2015 9:04 am

Thanks for the information, Tom! My DH is currently taking the TAS-102 drug and is tolerating it well so far, but we continue to look for new options in the future!
DH 64 Stage 4 on 4/14 ; cecal tumor; 5+ nodes ; mets to liver; colon resection
5/14 FOLFOX
9/14 - Liver surgery aborted; peri mets
10/14 CT mult.1-2 mm lung mets; FOLFIRI & Avastin
1/15 CT -liver & lung mets shrinking
3/15 PET - ? New met. site colon; CEA rising
7/15 Chemo has failed; looking for clinical trial
9/29/15 started TAS-102 trial
KRAS mutant; MSS

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: FPA008 (anti-CSF1r) + PD-1 Inhibitor Deal Announced (Trial Already Started)

Postby ieowi » Sat Oct 17, 2015 12:55 pm

I really don't know what can we do without you DK37. Thank you very much for keeping us up to date with these trials.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: FPA008 (anti-CSF1r) + PD-1 Inhibitor Deal Announced (Trial Already Started)

Postby Nik Colon » Sat Oct 17, 2015 3:22 pm

Awesome! Thanks!
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

Steph20021
Posts: 492
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: FPA008 (anti-CSF1r) + PD-1 Inhibitor Deal Announced (Trial Already Started)

Postby Steph20021 » Sat Oct 17, 2015 3:27 pm

Yes thank you for sharing your knowledge and educating me.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, hysterectomy et al, 2nd temp ileo, NED?
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
Jan/17- pulmonary embolism
Feb/17- 1 wk radiation to abdo wall
Currently stable suce Aug/16- on folfiri


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