Malaria as a cure for cancer

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radnyc
Posts: 446
Joined: Tue Apr 06, 2010 6:32 pm

Malaria as a cure for cancer

Postby radnyc » Thu Oct 15, 2015 1:29 pm

DX Jan 2010, at age 47
Feb - colon resection - 2/17 nodes positive
April - liver mets - Stage 4
3 months Folfox chemotherapy
August '10 liver resection and HAI pump
7 months chemo FUDR HAI and Folfiri systemic
NED since August 2010
Last treatment April 2011
HAI Pump removed Dec 2015

Steph20021
Posts: 553
Joined: Sat Dec 27, 2014 4:58 pm
Location: Ontario, Canada

Re: Malaria as a cure for cancer

Postby Steph20021 » Thu Oct 15, 2015 7:21 pm

Fingers crossed.
DX 1/31/14 @ 33- SPS-T4a(invades visceral peri), N2a(6/106 LN), M1a(ovary) (Stage 4a) MSS; BRAF V600E
2/1/14-subtotal col, lost R ovary, temp ileo
3/14-9/14- folfox; sepsis
11/14-CT/PET: L ovary met, pelvic met, (?)ghost liver met(?)
12/14-folfiri -13 rds kept me stable from 3/15-6/15
8/15-HIPEC, NED
09/15- cea 0.9
05/16- recurrence in abdo wall and lymph nodes
01/17- pulmonary embolism
02/17- 1 wk radiation to abdo wall
08/16- on folfiri
01/18-folfox
11/18- Beacon trial-encorafenib & cetuximab

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dianetavegia
Posts: 2731
Joined: Sat May 16, 2009 8:47 pm
Facebook Username: Diane Weldy Tavegia
Location: Villa Rica, Georgia

Re: Malaria as a cure for cancer

Postby dianetavegia » Sat Oct 17, 2015 4:09 pm

Pete at Sea had malaria (has malaria - do you ever heal?) and still had progression. I don't know if he still checks the board.
Stage III cc surgery 1/7/09. 12 tx FOLFOX
Stage IV PET = 1.5cm liver met. HR 4/11/12

14 years since dx and 11 years post liver resection.
Pronounced CURED and discharged by onc

“O Lord my God, I cried out to You, And You healed me.” Psalms 30:2

Lee
Posts: 6207
Joined: Sun Apr 16, 2006 4:09 pm

Re: Malaria as a cure for cancer

Postby Lee » Sat Oct 17, 2015 6:28 pm

My Uncle got Malaria during WWII. He recovered, butt never fully recovered from it. He died 10 year later and the the medical professions felt malaria was a contributing factor to his death. For the 10 yrs he always had serious health issues where malaria was a underlining factor.

Maybe a lot has changed today, but my understanding Malaria is serious stuff not to mess around with.

Lee
rectal cancer - April 2004
46 yrs old at diagnoses
stage III C - 6/13 lymph positive
radiation - 6 weeks
surgery - August 2004/hernia repair 2014
permanent colostomy
chemo - FOLFOX
NED - 16 years and counting!

Ron50
Posts: 699
Joined: Fri Feb 10, 2006 7:04 pm

Re: Malaria as a cure for cancer

Postby Ron50 » Sat Oct 17, 2015 7:40 pm

I know that live viruses have proved successful in treating some forms of cancer. One of my friends was dxed with severe testicular cancer he had to stay in hospital for chemo it was so savage. He survived only to be diagnosed with bladder cancer five years later. His main treatment was to be put into isolation and have live tuberculosis virus injected into his bladder. He did not get released from isolation until he had undergone a stringent regime of flushing his bladder with agents to remove all of the live virus. He is cancer free five years later. Ron.
dx 1/98
st 3 c 6 nodes
48 sessions 5Fu/levamisole
no recurrence cea <.5
numerous l/t side effects of chemo

nicola smith
Posts: 1040
Joined: Thu Oct 07, 2010 9:06 am

A General Cure for Cancer?

Postby nicola smith » Sat Oct 17, 2015 10:12 pm

As usual, this promising approach still needs to be tested in humans and will require at least another 4 years in development.

CRGuy, some of this work is being done at UBC...do you have any inside info?


"The hunt for a vaccine against malaria in pregnant women has provided an unexpected side benefit for Danish researchers, namely what appears to be an effective weapon against cancer. The scientists behind the vaccine aim for tests on humans within four years."


http://news.ku.dk/all_news/2015/10/mala ... or-cancer/
UC history
11/09: Dx, CEA 2.9
02/10: colectomy, temp ileo; pT3N1Mx
10/10: 12 Folfox6
03/11: jpouch
2010/11/12/13/14: 6 PET and/or CT's - NED
quarterly 03/2010- 03/2015: CEA range 0.8-1.3
03/2015: discharged to GP :D

nicola smith
Posts: 1040
Joined: Thu Oct 07, 2010 9:06 am

Re: A General Cure for Cancer?

Postby nicola smith » Sat Oct 17, 2015 10:21 pm

woops - I see radnyc alread covered this...CRGuy perhaps you could just combine the two or delete this one. :roll:
UC history
11/09: Dx, CEA 2.9
02/10: colectomy, temp ileo; pT3N1Mx
10/10: 12 Folfox6
03/11: jpouch
2010/11/12/13/14: 6 PET and/or CT's - NED
quarterly 03/2010- 03/2015: CEA range 0.8-1.3
03/2015: discharged to GP :D

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CRguy
Posts: 10473
Joined: Sun Feb 10, 2008 6:00 pm

Re: Malaria as a cure for cancer

Postby CRguy » Sat Oct 17, 2015 11:35 pm

Thanks nicola smith .... As requested I have merged the two topics and deleted duplicate posts.
CRGuy, some of this work is being done at UBC...do you have any inside info?

Just what I saw in our local papers on the 14th. It does seem that the UBC project involves the BCCA, Vancouver Coastal Health and Centre for Drug Research and Development. The actual Copenhagen - Vancouver connection was through Mads Daugaard, a research scientist at the Vancouver Prostate Centre and currently an assistant professor of urologic science at UBC.

The link you used above has a good overview of the research and the Cancer Cell publication has a good visual of the way the protein works both in infectious malaria AND as a tagged molecule for both therapeutic and imaging purposes !

Just to be clear though .... unlike some treatment research which uses active infectious organisms of other kinds ....
this does NOT use actual malarial infection so you are not creating the actual disease in a patient.

A specific malaria produced protein has been isolated and linked to a toxic molecule which then all attaches to specific sites on cancer cells.

A lotta good things are happening around BCCA (e.g. POG program) and I am excited to see things move ahead in so many areas !!!

AND since we are talking malaria .... check out our ongoing ***News Stories Thread*** ONGOING 2015 topic
Could a Malaria Drug Kill Cancer? from our intrepid newshound garbovatwin

Cheers all
CRguy
Caregiver x 4
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

lpas
Posts: 1010
Joined: Wed Nov 19, 2014 11:11 pm

Re: Malaria as a cure for cancer

Postby lpas » Sun Oct 18, 2015 8:44 am

dianetavegia wrote:Pete Lost at Sea had malaria (has malaria - do you ever heal?) and still had progression. I don't know if he still checks the board.


I was just going to mention the same thing. I think Pete was a stage II or III (?) NED. He caught malaria and his cancer came back shortly thereafter. I know he believes this was a precipitating factor in his recurrence.
11/14 Dx sigmoid CC @ 45yo
12/14 Colectomy + hysterectomy
Stage IIIB, T3N1bM0, 2/20 nodes, MSS, G2, KRAS(A146T), TP53, SMAD4, ERBB2, CEA 1.0
2/15-7/15 XELOX & celecoxib
2/19 clean scope
11/19 clean CT
Ongoing cimetidine & other targeted supplements
Mom to a 6 & 8yo

radnyc
Posts: 446
Joined: Tue Apr 06, 2010 6:32 pm

Re: Malaria as a cure for cancer

Postby radnyc » Sun Oct 18, 2015 10:04 am

Just to be clear the study is of a specific malaria protein that seems to act on cancer cells, it's not about giving full blown malaria to a subject.
DX Jan 2010, at age 47
Feb - colon resection - 2/17 nodes positive
April - liver mets - Stage 4
3 months Folfox chemotherapy
August '10 liver resection and HAI pump
7 months chemo FUDR HAI and Folfiri systemic
NED since August 2010
Last treatment April 2011
HAI Pump removed Dec 2015

Lydia666
Posts: 676
Joined: Sat Jun 06, 2015 6:50 pm
Location: Montreal, Canada

Re: Malaria as a cure for cancer

Postby Lydia666 » Sun Oct 18, 2015 3:20 pm

radnyc wrote:Just to be clear the study is of a specific malaria protein that seems to act on cancer cells, it's not about giving full blown malaria to a subject.

Haha! Right on! Otherwise we would exchange one life threatening disease for another.
Oct 2012- thyroid cancer
June 19, 2015 Dx@39 yrs- CRC-T3N1M0
No vascular, no perineural invasion
Aug-Sept 2015- 28 rad/5FU
Oct 28, 2015- LAR- temp ileo, neg. nodes- 0/11
March 2016- 6 rounds Xeloda/positive CHEK2 mutation
August 2016- DCIS and decided post prophylactic double mastectomy
May 2018 - clean CT
Sept 2018-clean scope
Devastation, total shock- oct 2018, invasion of peri mets
Dec 20 - 2 round of folfox
Mom to 4 & 7 yrs kids - at least i brought them to this level of independence.

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CRguy
Posts: 10473
Joined: Sun Feb 10, 2008 6:00 pm

Re: Malaria as a cure for cancer

Postby CRguy » Mon Oct 19, 2015 11:44 am

You make a very good point here Lydia666 .... BUTT !!! ... you just knew there had to be one :mrgreen:

early on in the 20th century active malaria was used as a "cure" for neurosyphilis !!!!
Seems there are some strains of malaria which make you MEGA sick with high fever ... BUTT are rarely fatal, so they thought they could get the body's immune system literally fired up with the fever helping to knock out the dreaded trep !

If you recall our member lohidoc and his own treatment with Coley's fluids ...... same rationale = activate your own immune system to knock out the cancer.

As usual though ... the devil is always in the details !
Cheers
CR
Caregiver x 4
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

PeterG
Posts: 52
Joined: Tue Feb 03, 2015 12:32 pm

Re: Malaria as a cure for cancer

Postby PeterG » Fri Nov 20, 2015 7:27 pm

Just ran across a Journal article on this--same research, lot more depth. Panacea? http://www.cell.com/cancer-cell/abstrac ... %2900334-7
Also, found an older article by Raymond Chang on related topic--inexpensive malaria drugs as possible cancer cures: http://www.ncbi.nlm.nih.gov/pubmed/22504324

So many straws to grasp at!
DX Aug. 2013 Resection 09/13.
08/14 CT : .7 CM pulmonary nodule--& multiple nodules.
03/15 15 dendritic cell vaccine-monthly
05/16 begin 3000 MG Xeloda & Avastin
11-16 shrinkage.”Sstable"
2/2017: Port installed. Begin Folfiri and Avastin
8/2017: Xeloda, Avastin and Iranotican. 3-wk cycle.
2-6-18: small pulmonary embolim—some growth in one pulmonary tumor. Start Xarelto.
2-8-18 : Change of chemo: Xeloda with Oxaliplatin no avastin.
9/2018: Tumor growth. Begin Stivarga.

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CRguy
Posts: 10473
Joined: Sun Feb 10, 2008 6:00 pm

Re: Malaria as a cure for cancer

Postby CRguy » Sat Nov 21, 2015 12:01 pm

I don't have subscribed access to the whole article, but yes ..... that first paper is the exact reference as Mads Daugaard is listed in the senior co-author.

The second ref is more on the New uses for Old drugs theme which I believe will start getting more and more attention as the oncogenomics initiatives pick up speed. Further info is available in this article which was posted in our ongoing News topic
could-malaria-drug-kill-cancer

Cheers
CR
Caregiver x 4
Stage IV A rectal cancer/lung met
17 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

pete43lost_at_sea
Posts: 65
Joined: Tue Mar 29, 2011 6:26 am

Re: Malaria as a cure for cancer

Postby pete43lost_at_sea » Mon Nov 23, 2015 3:01 am

Hi guys.
Hi Diane. God bless us all.

I suspect my malaria 4 years helped me join stage club faster . But I had peritoneal seeding. A fact of life I suspect.

I'm attending cancer vaccine 2015 today.

If you need help and want experimental help using vaccines on colitis viruses contact me

Still got some crc cells. Still alive. Earning a living helping others in Germany

My tip is ndv with dc vaccines primed pix ndv and tumor based mrna.

It's all on blog but will take 5 years to read.

happy thanks giving.

I always get into trouble when visit that's why it's once a year.

take care

Lots of love,

Pete

P's I am alive well and go home family Xmas after 40 operations 19 vaccines and a few million dollars poorer. I have learnt much and share as I can. But late stage 4 comebacks are possible not easy but life is fantastic.


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