The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1

Postby DK37 » Thu Oct 15, 2015 12:54 am

Curious to see "The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1"?

As a sequel to my very important MSI-testing Fight CRC column yesterday – I have also published a post on my personal blog with more CRC immunotherapy information and the interviews/profiles of two CRC patients currently being successfully treated in PD-(L)1 immunotherapy trials: Leta Withers and Stephen Estrada!

http://adventuresinlivingterminallyopti ... ies-vol-1/

Note the "Vol. 1" in the title - I assume I'll write additional volumes and make this a series, including hopefully soon MSS-CRC!

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1

Postby ieowi » Thu Oct 15, 2015 1:24 am

Going through it, thank you DK37 :mrgreen:
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

janderson
Posts: 679
Joined: Tue Mar 27, 2012 11:46 am

Re: The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1

Postby janderson » Thu Oct 15, 2015 12:22 pm

That is all so encouraging and I thank you for sharing but like you I am NOT MSI high. I had the test 2 months ago. So my question is there anything on the horizon that looks promising for stage IV CRC who are not MSI high.
DX 10-05 stage IV
liver resection 12-05 Folfox1-05 to 7-06
Liver resection 8-07 Folfiri 9-07 to 3-08
Liver resection 12-11
Recurrence 2/7/2014, liver, chestwall mets, 16 rounds chemo
7/3/14, y90 radioembolization, steady shrinkage
12/8/14, cryoablation to liver and chest wall
6/1 to 6/26 SBRT radio surgery
7/2 more cryo ablation to right lung
7/16 lung infection drain tube installed
9/4 chest wall resection to remove 2 ribs

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1

Postby DK37 » Thu Oct 15, 2015 3:09 pm

janderson wrote:That is all so encouraging and I thank you for sharing but like you I am NOT MSI high. I had the test 2 months ago. So my question is there anything on the horizon that looks promising for stage IV CRC who are not MSI high.


A lot of things look promising (various combination cocktails) in pre-clinical models for MSS CRC - but there is a big triage of things that work in animals that don't work in humans - you never know which one will work without clinical trials. There are a number of clinical trials in progress - no clinical data released yet, but I watch for data releases daily! I'll post any promising MSS clinical data I see to Colon Talk immediately when I do!

You have probably seen Sleen's thread about the NIH TIL trial - she has had success and she is MSS.

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

StephenWinsToday
Posts: 39
Joined: Mon Jun 22, 2015 12:08 pm
Facebook Username: Stephen Savage-Estrada

Re: The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1

Postby StephenWinsToday » Thu Oct 15, 2015 5:53 pm

Hey hey!

Just so people know...I'm the Stephen from this article! I'm open to questions or whatever!
7/15 DX'd at age 28 w/stage 4 crc. Met to mesentery. Also lynch+
7/15 right hemicolectomy
8/15 started 12 rounds FOLFOX.
2/15 Nanoknife. Gallbladder removal. resections. Complications landed me in ICU for 1 week. 8 blood transfusions.
5/15 Nanoknife failed. Enrolled in phase 1 trial of MPDL3280a (Atezolizumab) & Avastin.
7/15 CT shows I am responding to trial drug. All tumors and nodules shrinking.
8/15 CT scan shows stability of all nodules and target tumor
10/15 CT scan shows continued stability.

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1

Postby ieowi » Thu Oct 15, 2015 8:39 pm

I really hope they find something for mss/msi-low, I had a chat with a research doctor in MDA he mentioned that they are heavily focused on MSI-High as they can do something for them :evil: .

But he also said don't worry we are after mss but until now nothing has showed up with significant results as DK37 mentioned.

I also need to mention doing cms 400 test is a very good handy thing to keep around. You never know what you could find in it, preferably do it in foundation medicine a friend did two cms 400 tests one at MDA and another in foundation medicine his oncology said the foundation medicine show much more details and there were some differences !

I currently requested to do it .at foundation medicine of course. And they also do PD-l1 Test !!!!
Last edited by ieowi on Wed Oct 21, 2015 2:02 pm, edited 2 times in total.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: The Faces of Successful Colorectal Cancer Immunotherapies Vol. 1

Postby Nik Colon » Fri Oct 16, 2015 12:30 am

Thanks again for the info :)
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc


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