TAS-102 FDA Approved!

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

TAS-102 FDA Approved!

Postby DK37 » Tue Sep 22, 2015 1:00 pm

6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: TAS-102 FDA Approved!

Postby Nik Colon » Tue Sep 22, 2015 1:13 pm

AWESOME!
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

Valorie
Posts: 365
Joined: Mon May 05, 2014 6:33 am

Re: TAS-102 FDA Approved!

Postby Valorie » Tue Sep 22, 2015 5:11 pm

This is both wonderful news and at the same time, a little heartbreaking. Voxx was waiting for this to get approved. Damn.
Age 53 dx 2a CC 0/21 LN Oncotypedx score: 11
Sigmoidectomy 5/8/14
MSS No lymphovasular involvement,
6/14 PET - NED, 12/14 CT NED, 7/15 CT - NED
6/14-12/9/14 Xeloda 8 cycles
2/12/15 incisional hernia repair - Boooo!

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: TAS-102 FDA Approved!

Postby Nik Colon » Tue Sep 22, 2015 5:55 pm

So, with all the lingo and brain not working at the moment, would this help or not for me in the future if needed.

Sorry, brain can't read or process atm?

Ugh, I feel like such an idiot! Short term memory is on big time right now.
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

midlifemom
Posts: 1358
Joined: Wed Jan 15, 2014 10:58 am
Location: NJ

Re: TAS-102 FDA Approved!

Postby midlifemom » Tue Sep 22, 2015 6:04 pm

Dk, can you help us non-technical folks interpret?

First paragraph say approved for RAS (kras?) Wild.

But later on, it says all subgroups of study showed benefit, even kras with mutations.

So, is this just for kras wild? Or also good for kras mutant?

Thanks a so much for sharing and interpreting. :)
Stage 3 cc - dx Jan '14 age 53, cea 2.9
t2n2m0, KRAS mutant, MSS
Folfox Feb - Aug '14
Nov '14 cea 27.7 -2 liver masses
Dec '14 left lobectomy and HAI
Jan '15 FUDR and FOLFIRI
Aug '15 fudr done, liver clear, add avastin for lungs. Cea 4.3
Feb '16 CEA rising
May '16 2 wk break then drop Iri for 6 weeks.
Jul '16 cancer grew, constricted main bile duct. Stent inserted. On break till jaundice clears. CEA climbing. Doing reduced Folfox. Allergic to Oxali.
Sep'16 chemo failed. Trial or hospice?

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: TAS-102 FDA Approved!

Postby ieowi » Tue Sep 22, 2015 6:15 pm

Seems like for both kras wiled :shock: and kras mutant :evil: .

I wonder if it has less side effects than oxaliplatin. Or more :?
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

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chrissyrice
Posts: 1170
Joined: Thu Sep 23, 2010 8:44 am
Location: Atlanta, Georgia

Re: TAS-102 FDA Approved!

Postby chrissyrice » Tue Sep 22, 2015 7:00 pm

DX 10-31-09 Surgery 12-1-09 Sigmoid Colon
Stage IIIb T3,N2,MX; Chemo Feb 2010-Aug 2010; 4 rounds Folfox; 8 rounds 5FU +LV
12/2010 PET/CT Scan, Cancer Free
7/2012 CT Scan NED 2 years
10/2013 NED 3 years
8/2014 NED 4 years
Recurrence 6/2015: iliac lymph node(s)
8/2015 Surgery: 3 cm tumor removed+iliac artery graft
3/2016 CT Scan Stable
6/2016 Stable
9/2016 Stable
12/2016 Stable
3/2017 Stable
Recurrence 6/2017
12/2017 Surgery removed all cancer w/ clean margins
07-27-2018 Cancer-free for 7 months

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Mastan
Posts: 433
Joined: Sat Feb 19, 2011 11:12 am
Location: Albuquerque, NM

Re: TAS-102 FDA Approved!

Postby Mastan » Tue Sep 22, 2015 7:33 pm



Oh goody another poisonous option for us!
Dx 6/2010 rectal CA

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: TAS-102 FDA Approved!

Postby DK37 » Wed Sep 23, 2015 12:13 am



Thanks for posting that link Chris. I think this Fight CRC link does a very good job of explaining. In the first paragraph of the link I originally posted they only referred to KRAS-wid type in regards to the drugs previously failed by the trial participants, TAS-102 was approved for all KRAS wild or mutated.

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: TAS-102 FDA Approved!

Postby Nik Colon » Wed Sep 23, 2015 12:19 am

DK37 wrote:


Thanks for posting that link Chris. I think this Fight CRC link does a very good job of explaining. In the first paragraph of the link I originally posted they only referred to KRAS-wid type in regards to the drugs previously failed by the trial participants, TAS-102 was approved for all KRAS wild or mutated.

-DK

So that includes MSS too, so I could take it in future if needed? Just want to make sure
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: TAS-102 FDA Approved!

Postby DK37 » Wed Sep 23, 2015 12:26 am

Nik Colon wrote:So that includes MSS too, so I could take it in future if needed? Just want to make sure


Yes Nik - you should be able to take it! MSS is fine. TAS-102 is a new form of chemo, not an immunotherapy where MSS is having trouble (So far!!)

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

User avatar
Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: TAS-102 FDA Approved!

Postby Nik Colon » Wed Sep 23, 2015 12:28 am

DK37 wrote:
Nik Colon wrote:So that includes MSS too, so I could take it in future if needed? Just want to make sure


Yes Nik - you should be able to take it! MSS is fine. TAS-102 is a new form of chemo, not an immunotherapy where MSS is having trouble (So far!!)

-DK

Awesome! thanks! Sorry, been up now 28 hrs from steroids and not sure when I will fall asleep, then probably sleep just as long, ugh, brain is fried. Tends to be worst at beginning for remembering or comprehending things. Thanks for clearing it up where my brain can understand, lol
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

User avatar
Crystald
Posts: 142
Joined: Thu Feb 26, 2015 1:50 pm

Re: TAS-102 FDA Approved!

Postby Crystald » Wed Sep 23, 2015 2:42 pm

Excellent news! Hopefully it will benefit many who have run out of options.
Age 58
DX Jul 2014 Stage IVb CRC metastatic, unknown primary, CEA 1826
Inoperable, Chemo for life
KRASwt
MSI: not tested
29 Jul 14 Port
30 Jul - 19 Jan 2015 Folfox (12 cycles) CEA 164.5
9 Feb 15 - 20 May Flofiri failed (6 cycles) CEA 417.0
17 Jul 15 - Initiated Vectibix CEA 555.5
17 Jul 2015 - 14 Jan 2016 Vectibix
8 Feb 2016 - 11 Apr 2016 Xeloda
26 Apr 2016 Hospice

drebay
Posts: 220
Joined: Thu Mar 20, 2014 5:39 pm
Location: Oregon

Re: TAS-102 FDA Approved!

Postby drebay » Wed Sep 23, 2015 5:24 pm

Saw my Dr. today (good timing!) and he said that I will be able to try this!
6/13 Age 45 mom of 11 and 13 yr old DX Stage IV liver mets
7/13 colon surgery
9/13 Folfox
11/13 Xeliri
3/14 more liver mets
4/14 Lung Met
4/14 Liver resect delayed;lung resect done
5/14 Surg not an option
9/14 Stivarga
3/15 Back to IV Chemo
6/15 Avastin
9/15 In Clinical Trial

jortego128
Posts: 284
Joined: Sat Aug 15, 2015 7:47 am

Re: TAS-102 FDA Approved!

Postby jortego128 » Wed Sep 23, 2015 6:14 pm

Hey, any progress is good news!
DM 57 yrs old dx 6/8/15 T:4a N:1b M:1
KRAS G12D and TP53 C242fs mutations
Poorly Differentiated, Prominent Signet Ring Component(~50%)
Microsatellite Stable, 3 of (13)lymph nodes positive
15 Liver mets, largest 3.2 cm
Prim. Resection, Right Hemicolectomy 6/21/15
Start Chemo 7/20/15
2 rounds FOLFOX, 1 round FOLFOX +Avastin
CT 8/28/15, met growth, largest 4.5cm
4 rounds FOLFOX+Avastin
CT 11/06/15 mets stable, lungs clear
Begin FOLFIRI+Avastin 11/17/15, Stop chemo 1/26/16
Entered Paradise 3/11/2016


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