NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

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mariane
Posts: 704
Joined: Sun Sep 13, 2015 6:16 pm

NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby mariane » Tue Sep 22, 2015 12:59 pm

Was this study mentioned/posted already?

http://www.healio.com/hematology-oncolo ... ogy%20news
mom of now 14 years old twins, dx @ 40 in 6/2015 with upper rectal cancer, 10+ liver mets, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!

mariane
Posts: 704
Joined: Sun Sep 13, 2015 6:16 pm

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby mariane » Tue Sep 22, 2015 9:48 pm

Could be profitable to get cancer tissue tested for genetic mutations for free and to get tailored therapy with no cost. Hope it helps somebody.
mom of now 14 years old twins, dx @ 40 in 6/2015 with upper rectal cancer, 10+ liver mets, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!

Nik Colon

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby Nik Colon » Wed Sep 23, 2015 12:11 am

Did a search, not much found. Here it is

search.php?keywords=Nci+match&fid%5B0%5D=1

Hope someone else has more info

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DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby DK37 » Wed Sep 23, 2015 7:30 am

I'll repost the link that Cindie originally posted here on this thread. It is the official NCI desciption: http://www.cancer.gov/about-cancer/trea ... /nci-match

Here is the clinicaltrials.gov page: https://clinicaltrials.gov/ct2/show/NCT ... ice&rank=1

Scientifically I think it is fantastic that the NCI is doing this - setting up a HUGE trial to treat cancers based upon genetics instead of anatomy to see how targetted agents work in different cancer types. The loophole they are trying to close is that these drugs were tested & approved in the cancer types where the genetic mutations were the most common - this trial is meant to ensure that cancers that more rarely get the mutation are also clinically tested to see if patients with more rare cancer types get the benefit. Note I use the "rare" here in terms of genetics. CRC is very common but a CRC driven by ROS1 would be rare. But there are ROS1 drugs.

Of note: their list of drug/mutation types is currently pretty short. I have heard that next year they will be increasing the length of the list.

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby ieowi » Mon Sep 28, 2015 11:47 am

MDA oncology set up dad with an appointment for this trial, I hope it turns out good for him after hitting walls everywhere we ask. One thing I can't understand is why the oncology don't discuss trials as an option? I had to talk about it first for him to set us up with an appointment ?!! If I didn't do my home work we would have left Houston without knowing about this trial.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

JFrog
Posts: 21
Joined: Wed Aug 26, 2015 7:55 am

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby JFrog » Mon Sep 28, 2015 1:58 pm

We have been doing this stuff for 3 years and the main thing I have learned is that you MUST become your own advocate. We have been to numerous institutions and MDA is our main one and at each, some practitioners don't really think about you except while you are in their office while others do everything they can to help you. One must be as informed as possible and ask questions and be very pushy, even if it is not your nature. I am a healthcare provider myself and this has taught me to be much more of an advocate for each of my patients. By the way my wife is doing a targeted therapy trial at MDA now.
DW dx 5/2012 Stage II @ age 45; MSS;
Emergency colostomy
5FU radiation
Resection 10/2012 and FOLFOX
Recurrence local and liver 5/2013
FOLFIRI 8 rds, Xeloda and repeat radiation
Liver res. 3/2014, repeat pelvic res. 7/2014
Liver(2) and lung recurrence(1) 9/2014, Iri w/ pan until progression then FOLFOX w/ Avastin until progression
MDA Targeted Therapy Clinical Trial 8/2015, Progressed10/15-off trial
Iri and pan. 11/2015
SBO 2/16 with successful resection 3/9/16
Clinical Trial AZD1775, 4/21/16

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby ieowi » Mon Sep 28, 2015 2:44 pm

JFrog wrote:We have been doing this stuff for 3 years and the main thing I have learned is that you MUST become your own advocate. We have been to numerous institutions and MDA is our main one and at each, some practitioners don't really think about you except while you are in their office while others do everything they can to help you. One must be as informed as possible and ask questions and be very pushy, even if it is not your nature. I am a healthcare provider myself and this has taught me to be much more of an advocate for each of my patients. By the way my wife is doing a targeted therapy trial at MDA now.


Yea I guess we have to do that ourself, is your wife MSI-high ? I know they have nivolumab with another drug trial ? Dad is msi low so o guess nothing in MDA for him.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

JFrog
Posts: 21
Joined: Wed Aug 26, 2015 7:55 am

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby JFrog » Mon Sep 28, 2015 3:02 pm

She is MSS. Therefore not a good candidate for the PD-1's yet. She is in a study for the p53 mutation which many CRCs have. It is Vorinostat and MLN9708. There has been some good responses in phase I but only a few CRCs were involved, <10. If you haven't tried yet and go to MDA often, get you onc to refer you to the Center for Targeted Therapies there at MDA. They have a lot to offer in way of trials.
DW dx 5/2012 Stage II @ age 45; MSS;
Emergency colostomy
5FU radiation
Resection 10/2012 and FOLFOX
Recurrence local and liver 5/2013
FOLFIRI 8 rds, Xeloda and repeat radiation
Liver res. 3/2014, repeat pelvic res. 7/2014
Liver(2) and lung recurrence(1) 9/2014, Iri w/ pan until progression then FOLFOX w/ Avastin until progression
MDA Targeted Therapy Clinical Trial 8/2015, Progressed10/15-off trial
Iri and pan. 11/2015
SBO 2/16 with successful resection 3/9/16
Clinical Trial AZD1775, 4/21/16

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby ieowi » Mon Sep 28, 2015 3:22 pm

JFrog wrote:She is MSS. Therefore not a good candidate for the PD-1's yet. She is in a study for the p53 mutation which many CRCs have. It is Vorinostat and MLN9708. There has been some good responses in phase I but only a few CRCs were involved, <10. If you haven't tried yet and go to MDA often, get you onc to refer you to the Center for Targeted Therapies there at MDA. They have a lot to offer in way of trials.


Damn those guys I didn't knew any of this is available and no one even mentioned it. Thank you I will check it out also.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby ieowi » Mon Sep 28, 2015 3:33 pm

JFrog wrote:She is MSS. Therefore not a good candidate for the PD-1's yet. She is in a study for the p53 mutation which many CRCs have. It is Vorinostat and MLN9708. There has been some good responses in phase I but only a few CRCs were involved, <10. If you haven't tried yet and go to MDA often, get you onc to refer you to the Center for Targeted Therapies there at MDA. They have a lot to offer in way of trials.

Just checked dad pathology report,I guess dad doesn't have p53 mutation, I will still ask to make sure though.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

mariane
Posts: 704
Joined: Sun Sep 13, 2015 6:16 pm

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby mariane » Mon Sep 28, 2015 7:06 pm

JFrog Keep us posted. I also hold P53 mutation.
mom of now 14 years old twins, dx @ 40 in 6/2015 with upper rectal cancer, 10+ liver mets, CEA 140
chemo: 8/2015 - 10/2016 - 4xFOLFIRINOX, 2xFOLFOX, 8xFOLFIRI, 10x5FU, HAI pump -12xFUDR
4 surgeries, complete pathological response
CEA<2 since 10/2015
NED since May 2016

I praise God for every day with my family!

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: NCI-MATCH to assess treatments based on genetic abnormalities, not cancer type

Postby ieowi » Mon Nov 02, 2015 10:16 pm

NCI-Match seems like something any one can do parralel to his treatment, no matter what is your status, our Doctor at MDA phase one trail send Dad tumor for foundation medicin for test, to see if there is anything out there for him.

it worth mentioning that he also said your Dad cant enrol in the trial ( i still didnt figure out why will ask when we get the results ) but he will still do the same thing but not under the trail !??
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!


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