Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Please feel free to read, share your thoughts, your stories and connect with others!
User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby DK37 » Tue Sep 15, 2015 7:58 am

My September experimental CRC drug "The Currently Incurable Scientist" science column has published on the Fight Colorectal Cancer website! http://goo.gl/2ACPwU

“Putting Out the Inflammation Fire” discusses the roles of inflammation in cancer patients as well as Xilonix, a drug in Phase 3 clinical trials which hopes to combat CRC but… with a hoped for INCREASE in quality of life!

Please feel free to post question comments below. I’ll also upload a “Special Directors Cut” post with additional/behind-the-scenes info on my personal blog tomorrow.

Cheers,
-DK
Last edited by DK37 on Wed Sep 16, 2015 8:16 am, edited 1 time in total.
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

jillbugs4110
Posts: 266
Joined: Thu Jul 31, 2014 3:36 pm

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby jillbugs4110 » Tue Sep 15, 2015 10:37 am

Thank you
Live One Day At A Time
I Abandon myself to God
46 6 yo.....9yo...
stage 1V liver mets :-(
my one prayer to got to sustain me to raise my two babies this is my only wish then take me out if needed.

User avatar
Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby Nik Colon » Tue Sep 15, 2015 10:45 am

DK37 wrote:My September experimental CRC drug "The Currently Incurable Scientist" science column has published on the Fight Colorectal Cancer website! http://goo.gl/2ACPwU

“Putting Out the Inflammation Fire” discusses the roles of inflammation in cancer patients as well as Xilonix, a drug in Phase 3 clinical trials which hopes to combat CRC but… with a hoped for INCREASE in quality of life!

Please fee to post question comments below. I’ll also upload a “Special Directors Cut” post with additional/behind-the-scenes info on my personal blog tomorrow.

Cheers,
-DK

We have to pay now! J/k, thanks again for the info :)
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby DK37 » Wed Sep 16, 2015 8:14 am

I wrote a personal blog post to offer an unofficial extended Director’s Cut & some behind-the-scenes Blu-Ray bonus features for September's Fight CRC monthly Currently Incurable Scientist column… purely if anyone is interested in a slightly deeper dive into cancer inflammation & some of my personal thoughts on the Xilonix trial/drug discovery.

http://adventuresinlivingterminallyopti ... tion-fire/

Consider it a bonus Disc 2 - hopefully without too many bloopers!

Cheers,
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

User avatar
CRguy
Posts: 9638
Joined: Sun Feb 10, 2008 6:00 pm

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby CRguy » Wed Sep 16, 2015 3:41 pm

Gonna head over with a bag of popcorn and get started !

Thanks again for all the timely and personalized posts and info.

Mega Cheers buddy
CR
Caregiver x 3
Stage IV A rectal cancer/lung met
11 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

User avatar
CRguy
Posts: 9638
Joined: Sun Feb 10, 2008 6:00 pm

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby CRguy » Thu Sep 17, 2015 11:23 am

As always very interesting info !

The whole "immune" system .. cascades, innate, adaptive, cellular, humoral ...... has GOT to lie at the root of all cellular and microenvironmental neoplastic processes.
We keep looking for the switches to turn things off and on, and with the right targets and switches we could have a winner.

Looking forward to the sequel :)

Cheers
CR
Caregiver x 3
Stage IV A rectal cancer/lung met
11 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

daniel.qin
Posts: 25
Joined: Tue May 26, 2015 9:07 pm
Location: Sunnyvale CA

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby daniel.qin » Thu Sep 17, 2015 12:00 pm

Thanks for the information!

I am on it now. I have finished 3 cycles. The side effect is not big. It seems not working for me. My CEA rise every time.

Thanks,
-Daniel
39 years old Male
4/12 - colon surgery stage III
12/12 - 12 round FOLFOX
5/14 - met to spleen, colon surgery, spleen remove, radiation, XELOX
KRAS-mutated, BRAF wild type, MSI-stable.
11/14 - Abdomen wall met, surgery, FOLFIRI+Avastin
3/15 - CT, NED
Chinese herbs medicine
5/15 - CT, progressing-FOLFIRI+Avastin
6/15 - cannabis oil supplements
8/15 - Xilonix fail
10/15 - RRX 001

janderson
Posts: 679
Joined: Tue Mar 27, 2012 11:46 am

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby janderson » Thu Sep 17, 2015 12:12 pm

Very interesting article that gives some hope. Do you know if and when this drug would go for FDA approval, possibly fast track? and if and when it could become available/approved for standard of care.
DX 10-05 stage IV
liver resection 12-05 Folfox1-05 to 7-06
Liver resection 8-07 Folfiri 9-07 to 3-08
Liver resection 12-11
Recurrence 2/7/2014, liver, chestwall mets, 16 rounds chemo
7/3/14, y90 radioembolization, steady shrinkage
12/8/14, cryoablation to liver and chest wall
6/1 to 6/26 SBRT radio surgery
7/2 more cryo ablation to right lung
7/16 lung infection drain tube installed
9/4 chest wall resection to remove 2 ribs

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby DK37 » Thu Sep 17, 2015 2:07 pm

daniel.qin wrote:Thanks for the information!

I am on it now. I have finished 3 cycles. The side effect is not big. It seems not working for me. My CEA rise every time.

Thanks,
-Daniel


Sorry to hear about the CEA rise Daniel... You are in a double-blind study correct, so unsure if you are getting the Xilonix drug? Wishing you all the best-
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

User avatar
DK37
Posts: 510
Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby DK37 » Thu Sep 17, 2015 2:15 pm

janderson wrote:Very interesting article that gives some hope. Do you know if and when this drug would go for FDA approval, possibly fast track? and if and when it could become available/approved for standard of care.


From this August investor update, the company says that enrollment in the European Phase 3 trial was complete. http://investors.xbiotech.com/phoenix.z ... ID=2079901 If the data is good, that would mean asking for European approval in 2016.

From this second investor update, the company says that enrollment for the FDA trial is expected to be complete in late 2016. http://investors.xbiotech.com/phoenix.z ... ID=2078118 If the data is good, that would mean asking for FDA approval in 2017. It has FDA fast track designation.

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List

stu
Posts: 874
Joined: Sat Aug 17, 2013 5:46 pm

Re: Currently Incurable Scientist: Putting out the Inflammation Fire (Xilonix)

Postby stu » Thu Sep 17, 2015 2:28 pm

Thanks for sharing. Very informative.
I have to say I am totally taken with you blog photo. I have just shown it round my family.
Kind regards
Stu
supporter to my mum who lives a great life despite a difficult diagnosis
stage4 2009 significant spread to liver
2010 colon /liver resection
chemo following recurrence
73% of liver removed
enjoying life treatment free
2016 lung resection
Oct 2017 nice clear scan . Two lung nodules disappeared
Oct 2018. Another clear scan .


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: clj12288, Gravelyguy, mandosquiddy, martd, Punky44, Sskhan, Tardis, Thedruid and 60 guests