My Dads onc recommended we look into this trial despite my Dad being MSS:
https://clinicaltrials.gov/ct2/show/NCT02437071
Is it possible that Keytruda in combo with cryoablation could help the MSS crowd?? I emailed Dr Segal about that very question but haven't heard back in the last few days.
Any help would be greatly appreciated!
Katy
Keytruda and cryoablation for MSS??
Re: Keytruda and cryoablation for MSS??
It's possible Katy - ablation (like radiation) kills cancer cells in an "immunogenic" way (i.e. in a way that presents the guts of the dead cell to the immune system in a way that makes it easier for the cancer to get noticed/attacked).
Won't know until the clinical trial if it helps MSS-CRC but there is scientific rationale behind trying it-
-DK
Won't know until the clinical trial if it helps MSS-CRC but there is scientific rationale behind trying it-
-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
DK37 Science Posts List
Re: Keytruda and cryoablation for MSS??
Thank you!!!
Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”
Who is online
Users browsing this forum: No registered users and 167 guests