RRx-001 Phase 1 Clinical Trial Results Published in Lancet Oncology

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DK37
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Joined: Tue Sep 17, 2013 8:31 am
Location: San Diego

RRx-001 Phase 1 Clinical Trial Results Published in Lancet Oncology

Postby DK37 » Thu Aug 20, 2015 11:50 am

Hi Everyone,

A quick update on RRx-001 (for previous info containing preliminary Phase 2 data see: http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=50662&hilit=rrx+001+trial ).

Although the preliminary Phase 2 data looks encouraging, it is still pending to be seen if it continues to look good in higher patient numbers. I am hoping they will provide a Phase 2 trial clinical update this fall but we'll see........ I am intrigued by this molecule both by the high response rate in the initial small numbers of patients tested as well as the very low side effect profile seen thus far. It appears to resensitize tumors in multiple patients to irinotecan after tumors become resistant.

This week they published in detail their Phase 1 clinical results in the journal "Lancet Oncology". If you are considering this trial, this paper is important for your oncologist to see (along with the preliminary Phase 2 results at the link above) since there is a good chance they have never heard of the molecule. Unfortunately the paper is not free (only the abstract is), costs about $30. http://www.thelancet.com/pdfs/journals/lanonc/PIIS1470-2045(15)00089-3.pdf

It is only being tested at a few sites (UCSD, Stanford and I believe if you have a military connection, at Walter Reed on the east coast) and it is randomized 2:1 to receiving Regorafenib, here is the Clinicaltrials.gov link: https://clinicaltrials.gov/ct2/show/NCT02096354?term=rrx-001&rank=5

-DK
6/4/2012 Dx Stage 3C CRC @ 40 yo. MSS, KRAS-WT, BRAF-WT, p53-mut
7/12 FOLFOX/FOLFIRI
2/13 NED!
8/13 Enlarged lymphs - Stable
10/14 Stage IV. Lung & Lymph mets. 5-FU+bev
3/15 Cetuximab
11/15 FOLFIRI + bev
11/16 Signs of FOLFIRI resistance (Lymph mets)
1/17 Palliative radiation for resistant mets
2/17 FOLFIRI + bev + Maraviroc (off-label)
3/17 FOLFIRI + Erbitux + Maraviroc (off-label)
MSS-CRC Clinical Trial Finder: http://trialfinder.fightcrc.org/
2016 Colondar 2.0 Model
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Stanfordmom
Posts: 612
Joined: Wed May 14, 2014 1:32 am

Re: RRx-001 Phase 1 Clinical Trial Results Published in Lancet Oncology

Postby Stanfordmom » Thu Aug 20, 2015 4:59 pm

Thanks for sharing. Very exciting development!
DX 4/2/2014 at 44, stage 4, mets liver and ovaries
Mom to 2 boys
Three surgeries, HAI pump and lots of chemo
fighting!

ieowi
Posts: 202
Joined: Mon Jul 27, 2015 1:27 am

Re: RRx-001 Phase 1 Clinical Trial Results Published in Lancet Oncology

Postby ieowi » Fri Aug 21, 2015 1:52 pm

Thank you DK37, After you mentioned it last time I've been reading a lot about it, seems promising for my father tumor.

Thank you for keeping us updated.
Father 58 yo , Colon cancer IV + 4 Lymph. 7/2015
K-ras Mutant,GNAS,FBXW7,PIK3CA, MSI-low
4 cycles irinotecan+FU5
developed abdominal met + lung met...Failed
4 cycle Oxaliplatin+folfox. peri met growing...Failed
unofficial trial !!!

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Nik Colon
Posts: 5210
Joined: Thu Jan 08, 2015 3:35 pm
Location: MN

Re: RRx-001 Phase 1 Clinical Trial Results Published in Lancet Oncology

Postby Nik Colon » Sun Aug 23, 2015 5:27 am

Thanks again DK
KRAS-mut G12V,MSS
Stage IVa Sig CC 2 lvr mets 1/12 Ln
(3, =<3 lng spots at dx til 5/16)
=T3N1aM1a 4cmX4mm (lng not included)
dx 12/2014 at age 39
CEA 1/15-4.9, 12/16-4.9 again
neoadj FOLFOX 1/15-3/15 (4tx, 3w/1wo oxi)
Col/Lvr surg 4/23/15 NED
adj FOLFIRI start 6/15-9/15 (8tx, 5w/3wo iri)
1 sml lvr spot/cyst
12/6/16 multi lung spots/mets?
No longer NED :(
My tx ongoing-start 1/20/15
Adding your SIGNATURE, etc


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