Oxiplatin and 5fu pump..... Last chance.

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Oxiplatin and 5fu pump..... Last chance.

Postby Jason43 » Sun Aug 16, 2015 1:34 pm

After being on and attempting all the others I'm left to try this. I never wanted to try oxiplatin. It was the one chemo drug that I didn't want to do. The side effects scare me. My CEA has went way up and the scan showed massive growth. The tumors grew from 1.2 cm to 3.8 cm. there were no new tumors just growth in the ones I have. I did attempt the liver resection and lung resection in January but unfortunately the tumors grew back and now 4xs as big. I told my oncologist that I'm only doing 3 rounds of this and if there's no improvement I'm done with chemo. I just don't know when enough is enough? How does this end?
Stage 4
Many spots on liver 11/19/13
Unable to resect liver
Tumor removed 11/26/13
Liver resection 11/7/14
Lung resection 1/10/15
New tumors on liver already after 1st scan after surgeries.
Back on chemo 2/4/15
CEA from 1.7 to 37.2 8/10/2015
CEA 22.5 but have quadrupled in my lungs
Went through every chemo
I fought the fight. Gods hands now. Or Trials?

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Re: Oxiplatin and 5fu pump..... Last chance.

Postby cathy123 » Sun Aug 16, 2015 2:34 pm

So sorry. I hope folfox is effective for you. Oxi wasn't fun, but it wasn't as bad as I had expected. Sending prayers.

Diagnosed 10/14 low rectal cancer age 43
Clinical T2NXMX
Radiation/xeloda 12/14-1/15
LAR with temp Ileo 3/15
pT2N0M0, lymphatic invasion 0/37 nodes
4 xelox, 1 xeloda only
Reversal 9/15
Mom to 9&11 year olds

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Re: Oxiplatin and 5fu pump..... Last chance.

Postby sjring » Sun Aug 16, 2015 3:07 pm

Doing my second attempt on the Oxili now. The side effects aren't fun but if it works.....

Everyone reacts differently, however, the side effects tend to get worse the more doses you have. I've had two so far in this go around, and I'm having mild hand & foot numbness. The cold insensitivity hasn't been too bad but then it's not like it's the dead of winter as it was the last time I was on it.

Best of luck!
50 YO Husband & father of 2 teenagers.
DX 9/9/13 Stage 4 cc (at age 48)
16 Rounds FOLFOX + Avastin (Oct-13 to May-14)
Maintenance chemo - Avastin & 5-FU infusions (Jun-14 to Jul-15)
Jul-15: Mets to lymph nodes, resuming FOLFOX
Sep-15: MRI showed stability, back to maintenance chemo.

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Re: Oxiplatin and 5fu pump..... Last chance.

Postby LeonW » Sun Aug 16, 2015 6:56 pm

I hope the oxi will be effective. Thanks for giving it a try. I made my mets shrink from round 3.
Dec 2012 - CC 2 unresect liver mets, CEA 41.8 (MM 65yrs)
Jan 2013 - colectomy @ spleen 2/26 nodes IVa T3N1bM1a
Feb-Jul - 1x Xelox-7x Xelox/Avastin (neo adjuv), shrinkage from #3
Aug - 2 PV embolizations (both failed)
Sep 2013 - R liver resect, 25d hosp (liver failure/delirium, lung emboli, encephalopathy), cancer dead (pCR)
2014/15 - recovery, scopy: 2 polyps
2016 - new town, new life
June 2018 - 5 yr mark, scopy: 2 polyps
1.3-1.4 CEA/clean CTs: 4x2014, 6x2015-17, 2x2018-19 :D, next June 2020

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Joined: Tue Jun 16, 2015 4:50 pm

Re: Oxiplatin and 5fu pump..... Last chance.

Postby Joannerogers » Sun Aug 16, 2015 8:36 pm

I have had 6.5 oxi treatments. They were not bad for me, the usual hand/foot neuropathy, jaw pain with first bite of food, and bad eye pain. These all get better or ease up after about 3 days. None are intolerable. I had an allergic reaction with round 7, which apparently happens to some people, and this Tuesday they will try to do oxi again with mega steroids before. The therapy after 6 treatments reduced my tumors over 50% so if I were you I'd consider giving it a try.
53yo married 27 years, 2 children, 24 and 25
Diagnosed april 23,2015 rectosigmoid
Starting CEA 1845
Port placement and liver bx April 27
Folfox started april 29
Avastin added on May 6
Stage IV crc with mets to 50% of liver

10/13/15 dc'd transfusion #12...toxic
Pet/ct scan on 11/3/15
20% liver resected all margins clear 11/30/15
8/18/15 cea 21.
9/15/15 cea 13.9
10/13/15 cea 14.4
1/22/2016 cea 2.5
LAR 02/15/16 all clear

Nik Colon

Re: Oxiplatin and 5fu pump..... Last chance.

Postby Nik Colon » Sun Aug 16, 2015 11:17 pm

My reply on your other thread....
I agree to just try, it did great for shrinking for me and I only did the first 3 with oxi, shrunk to half size

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Re: Oxiplatin and 5fu pump..... Last chance.

Postby wwroam » Mon Aug 17, 2015 12:07 am

It was only after the 12th cycle of Oxi that I developed neuropathy simultaneously in hands and feet.
My SO developed it in her hands ( but not the feet) after 9 rounds of chemo. The 10th cycle has been 5FU and Avastin only.
It does take many cycles for neuropathy to develop and I believe for patients with metastases it is very effective.
Stage 3a DX 25/06/07
Folfox complete 30/01/08
7 years NED
Port scheduled for removal 8/02/10 Gone.
PSA .54 No prostate problems
Diagnosed Type 2 Diabetic
SO diagnosed CC Stage IV Liver Mets 23/03/15

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Re: Oxiplatin and 5fu pump..... Last chance.

Postby CRguy » Tue Aug 18, 2015 5:38 pm

you can give it a try and if it is messing with you too much, ask for a dose reduction, decrease number of cycles or stop.

I did the dirty dozen with 1 dose reduction of Oxi @ cycle 8 of 12.
Still have "tingling" neuropathy of hands and feet now 5 years out … BUTT as a vet was able to do regular surgeries with scalpels and lasers ….
SO IMO it was a win for me.

Best wishes
CR on the Journey
Caregiver x 4
Stage IV A rectal cancer/lung met
12 Year survivor
my life is an ongoing totally randomized UNcontrolled experiment with N=1 !
Review of my Journey so far

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Re: Oxiplatin and 5fu pump..... Last chance.

Postby Ajane » Tue Aug 18, 2015 5:55 pm

I'll start round 4 of Oxy on Thursday. Reduction began with round two which made side effects tolerable so far. Hopefully, you'll tolerate it too and get good results. Like others have said, you can always reduce the dosage or cycles, if necessary.
7/13, T2, G3, Ultra-low. CEA 5.7 KRAS Wild, MSS
8-9/13 6 wks Xeloda/radiation
12/13 TEM pCR NED
5/15 CEA 4.6 PET 1.5 cm met, UL Lobectomy
6-10/15: Rounds 1-2 Xelox+Avastin; 3-8 Folfox+Avastin
10/15-4/16: 12 rounds Avastin
9/2016 CEA 4.2, 12 mm AP node
11/2016 CEA 4.3. PET/CT. 16mm AP nodal met removed
4 wks chemorad
2/2017 NED CEA 2.4
Carafate to tx esophageal ulcers caused by rad
Avastin maintenance postponed

2 Corinthians 12:9

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