4 1BB has been found to increase the response of other forms of cancer immunotherapies, like CAR T cell and checkpoint inhibitor PD 1, and is therefore being used in combination clinical trials,
Immunotherapy combinations are the most promising forms of cancer treatment.
http://journal.frontiersin.org/article/ ... 00117/full
http://www.reuters.com/article/2015/08/ ... CZ20150807