900 pt CEA jump after 1 cycle of trial TAS-102

[fourT's]

I can't seem to find too much on the forum about the clinical trial TAS-102. All other chemo treatments were no longer working for my husband so he was put on the trial 1 month ago. His CEA before starting was 442 which is high for him. After 1 round of the trial it jumped to 1307 which is simply shocking to us. On the trial he takes 8 pills a day for 5 days and then has the weekend off before starting another 5 days. He then got 2 weeks off before starting another cycle and that is when the CEA was checked. They did a CT scan before the trial started and planned on doing another scan after 3 cycles. I know it's only been 1 cycle but we are not feeling hopeful about the treatment. We are hoping to see if they can do a PET scan and include the skull since he has had more headaches than usual over the past few months.

Can anyone else lend some knowledge about their experience of TAS-102?

Thank you,

Tracy

[Voxx66]

Chemo does strange things to CEA. I would confirm growth with scans before writing tas-102 off.

[fwilkins]

My daughter has completed one cycle of TAS 102 as well. Her doctor told her that many of their patients have a higher CEA after the first cycle and then it goes down. I have been concerned because she is having some pain for the first time in 20 months. She will be getting her CEA checked next Tuesday and will be scanned late August. I will let you know the results. She is tolerating this drug very well, but is having to fly to Denver from Houston. Hoping the best for you!

[pukalania]

Hi
So sorry about this... My husband had similar jump in CEA after first cycle of tas102 .. From 270 to 1800...his pain was also significantly increased and he lost weight so onc felt we should stop it. 2 weeks later we ended up doing ct scan due to possible bile duct obstruction... Unfortunately ct scan showed significant disease progression... So now we don't even know of he can start Stivagra ...

I would ask for a ct scan ... Hope your case turns out different
Xoxo